CD40LG

CD40配體(CD40LG/CD154/TNFSF5)是CD40的天然三聚體配體，是一種39kDa的II型膜糖蛋白，其在多種細(xì)胞類型上表達(dá)，包括活化的CD4+T細(xì)胞、活化的B細(xì)胞、記憶CD8+T細(xì)胞、激活的自然殺傷細(xì)胞、粒細(xì)胞、內(nèi)皮細(xì)胞、平滑肌細(xì)胞、巨噬細(xì)胞和活化血小板。CD40是在各種免疫細(xì)胞（如B細(xì)胞、樹突細(xì)胞和巨噬細(xì)胞）上表達(dá)的受體蛋白。CD40L可與CD40相互作用，觸發(fā)這些免疫細(xì)胞的過度刺激，導(dǎo)致免疫反應(yīng)級聯(lián)和介導(dǎo)炎癥的過度生產(chǎn)，從而導(dǎo)致很多自身免疫性疾病。因此，靶向CD40L，阻斷CD40L與CD40和其他結(jié)合位點(diǎn)的相互作用，可潛在的降低自身免疫和炎癥反應(yīng)。針對CD40L開發(fā)的藥物，可用于治療自身免疫性疾病，比如視神經(jīng)脊髓炎（NMOSD）、重癥肌無力和lgG4相關(guān)疾病，干燥綜合征以及腎移植脫敏等等。

Recombinant Human CD40LG 活性蛋白實(shí)驗(yàn)驗(yàn)證數(shù)據(jù)

High Purity Validated by
SDS-PAGE

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

Excellent Bioactivity Validated by Functional ELISA

Measured by its binding ability in a functional ELISA. Immobilized CD40L at 2 μg/ml can bind Anti- CD40L Rabbit Monoclonal Antibody(CSB-RA156386A0HU), the EC₅₀ is 2.353-3.232 ng/ml.

Excellent Bioactivity Validated by LSPR Assay

Human CD40 protein hFc tag (CSB-MP004936HU1) captured on COOH chip can bind Human CD40L protein hFc and Flag tag (CSB-MP004937HU3) with an affinity constant of 2.06 nM as detected by LSPR Assay.

CD40LG Antibody

CD40LG Protein

CD40LG ELISA Kit

CD40LG Antibodies

CD40LG for Homo sapiens (Human)

產(chǎn)品貨號	產(chǎn)品名稱	種屬反應(yīng)性	應(yīng)用類型
CSB-PA004937GA01HU	CD40LG Antibody	Human,Mouse,Rat	ELISA,WB,IHC
CSB-PA06005A0Rb	CD40LG Antibody	Human	ELISA
CSB-PA06005B0Rb	CD40LG Antibody, HRP conjugated	Human	ELISA
CSB-PA067336	CD40LG Antibody	Human,Mouse	ELISA,WB

CD40LG Proteins

CD40LG Proteins for Mus musculus (Mouse)

產(chǎn)品貨號	產(chǎn)品名稱	來源
CSB-EP004937MO1 CSB-BP004937MO1 CSB-EP004937MO1-B	Recombinant Mouse CD40 ligand (Cd40lg), partial	E.coli Baculovirus In Vivo Biotinylation in E.coli
CSB-CF004937MO	Recombinant Mouse CD40 ligand (Cd40lg)	in vitro E.coli expression system

CD40LG Proteins for Homo sapiens (Human)

產(chǎn)品貨號	產(chǎn)品名稱	來源
CSB-YP004937HU1	Recombinant Human CD40 ligand (CD40LG), partial	Yeast
CSB-EP004937HU4	Recombinant Human CD40 ligand (CD40LG), partial	E.coli
CSB-AP002211HU	Recombinant Human CD40 ligand (CD40LG) (C194W), partial (Active)	E.Coli
CSB-CF004937HU	Recombinant Human CD40 ligand (CD40LG)	in vitro E.coli expression system
CSB-EP004937HU1 CSB-BP004937HU1 CSB-MP004937HU1 CSB-EP004937HU1-B	Recombinant Human CD40 ligand (CD40LG), partial	E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli
CSB-AP005191HU	Recombinant Human CD40 ligand (CD40LG), partial (Active)	E.coli
CSB-MP004937HU3	Recombinant Human CD40 ligand (CD40LG), partial (Active)	Mammalian cell
CSB-MP004937HU3-B	Recombinant Human CD40 ligand (CD40LG), partial, Biotinylated	Mammalian cell
CSB-EP004937HU1a0	Recombinant Human CD40 ligand (CD40LG), partial	E.coli

CD40LG Proteins for Macaca mulatta (Rhesus macaque)

產(chǎn)品貨號	產(chǎn)品名稱	來源
CSB-YP004937MOW CSB-BP004937MOW CSB-MP004937MOW CSB-EP004937MOW-B	Recombinant Macaca mulatta (Rhesus macaque) CD40 ligand (CD40LG), partial	Yeast Baculovirus Mammalian cell In Vivo Biotinylation in E.coli
CSB-EP004937MOW	Recombinant Macaca mulatta CD40 ligand (CD40LG), partial	E.coli

CD40LG Proteins for Felis catus (Cat) (Felis silvestris catus)

產(chǎn)品貨號	產(chǎn)品名稱	來源
CSB-YP004937CA1 CSB-EP004937CA1 CSB-BP004937CA1 CSB-MP004937CA1 CSB-EP004937CA1-B	Recombinant Cat CD40 ligand (CD40LG), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli
CSB-CF004937CA	Recombinant Cat CD40 ligand (CD40LG)	in vitro E.coli expression system

CD40LG Proteins for Canis familiaris (Dog) (Canis lupus familiaris)

產(chǎn)品貨號	產(chǎn)品名稱	來源
CSB-YP004937DO1 CSB-EP004937DO1 CSB-BP004937DO1 CSB-MP004937DO1 CSB-EP004937DO1-B	Recombinant Dog CD40 ligand (CD40LG), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

CD40LG Proteins for Cercocebus atys (Sooty mangabey) (Cercocebus torquatus atys)

產(chǎn)品貨號	產(chǎn)品名稱	來源
CSB-YP004937DRI1 CSB-EP004937DRI1 CSB-BP004937DRI1 CSB-MP004937DRI1 CSB-EP004937DRI1-B	Recombinant Cercocebus atys CD40 ligand (CD40LG), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli
CSB-CF004937DRI	Recombinant Cercocebus atys CD40 ligand (CD40LG)	in vitro E.coli expression system

CD40LG Proteins for Sus scrofa (Pig)

產(chǎn)品貨號	產(chǎn)品名稱	來源
CSB-YP004937PI CSB-EP004937PI CSB-BP004937PI CSB-MP004937PI CSB-EP004937PI-B	Recombinant Pig CD40 ligand (CD40LG), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

CD40LG Proteins for Aotus trivirgatus (Night monkey) (Douroucouli)

產(chǎn)品貨號	產(chǎn)品名稱	來源
CSB-YP004937DNI CSB-EP004937DNI CSB-BP004937DNI CSB-MP004937DNI CSB-EP004937DNI-B	Recombinant Aotus trivirgatus CD40 ligand (CD40LG), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

CD40LG Proteins for Callithrix jacchus (White-tufted-ear marmoset)

產(chǎn)品貨號	產(chǎn)品名稱	來源
CSB-YP004937CYL CSB-EP004937CYL CSB-BP004937CYL CSB-MP004937CYL CSB-EP004937CYL-B	Recombinant Callithrix jacchus CD40 ligand (CD40LG), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

CD40LG Proteins for Macaca nemestrina (Pig-tailed macaque)

產(chǎn)品貨號	產(chǎn)品名稱	來源
CSB-YP004937MOX CSB-EP004937MOX CSB-BP004937MOX CSB-MP004937MOX CSB-EP004937MOX-B	Recombinant Macaca nemestrina CD40 ligand (CD40LG), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

CD40LG Proteins for Gallus gallus (Chicken)

產(chǎn)品貨號	產(chǎn)品名稱	來源
CSB-YP004937CH CSB-EP004937CH CSB-BP004937CH CSB-MP004937CH CSB-EP004937CH-B	Recombinant Chicken CD40 ligand (CD40LG), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

CD40LG Proteins for Rattus norvegicus (Rat)

產(chǎn)品貨號	產(chǎn)品名稱	來源
CSB-YP004937RA CSB-EP004937RA CSB-BP004937RA CSB-MP004937RA CSB-EP004937RA-B	Recombinant Rat CD40 ligand (Cd40lg), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli