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CD38

CD38全稱(chēng)為分化簇38,也被稱(chēng)為ADP-核糖環(huán)化酶或T10抗原,是一種廣泛分布于免疫細(xì)胞表面的II型跨膜糖蛋白。CD38通過(guò)催化煙酰胺腺嘌呤二核苷酸(NAD+)生成環(huán)腺苷二磷酸核糖(cADPR)和腺苷二磷酸核糖(ADPR),在細(xì)胞代謝調(diào)控、鈣離子信號(hào)傳導(dǎo)及免疫應(yīng)答中發(fā)揮核心作用。其高表達(dá)特征常見(jiàn)于多發(fā)性骨髓瘤、淋巴瘤等血液系統(tǒng)惡性腫瘤,同時(shí)也與系統(tǒng)性紅斑狼瘡、類(lèi)風(fēng)濕關(guān)節(jié)炎等自身免疫性疾病密切相關(guān)。
近年來(lái)CD38已成為血液腫瘤治療的重要靶點(diǎn),達(dá)雷妥尤單抗(Darzalex)作為首個(gè)靶向CD38的單克隆抗體,通過(guò)抗體依賴(lài)細(xì)胞介導(dǎo)的細(xì)胞毒作用(ADCC)和補(bǔ)體依賴(lài)的細(xì)胞毒作用(CDC)顯著改善了多發(fā)性骨髓瘤患者的生存預(yù)后。緊隨其后的Isatuximab(Sarclisa)也在全球范圍內(nèi)獲批上市。目前針對(duì)該靶點(diǎn)的創(chuàng)新療法持續(xù)涌現(xiàn),包括CD38-CAR-T細(xì)胞療法、雙特異性抗體等新型免疫治療策略已進(jìn)入臨床試驗(yàn)階段,同時(shí)在實(shí)體瘤治療領(lǐng)域的應(yīng)用探索也在積極推進(jìn)。

熱銷(xiāo)產(chǎn)品

Recombinant Human ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 (CD38), partial (CSB-EP004929HU2)

驗(yàn)證數(shù)據(jù)

CSB-EP004929HU2

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

CD38 Recombinant Monoclonal Antibody (CSB-RA796695A0HU)

驗(yàn)證數(shù)據(jù)

CSB-RA796695A0HU

Western Blot
Positive WB detected in: THP-1 whole cell lysate
All lanes: CD38 antibody at 1:2000
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 35, 14 kDa
Observed band size: 42 kDa

CSB-RA796695A0HU

IHC image of CSB-RA796695A0HU diluted at 1:100 and staining in paraffin-embedded human prostate cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4℃ overnight. The primary is detected by a Goat anti-rabbit IgG polymer labeled by HRP and visualized using 0.05% DAB.

CSB-RA796695A0HU

IHC image of CSB-RA796695A0HU diluted at 1:100 and staining in paraffin-embedded human tonsil tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4℃ overnight. The primary is detected by a Goat anti-rabbit IgG polymer labeled by HRP and visualized using 0.05% DAB.

CD38 Antibodies

CD38 for Homo sapiens (Human)

CD38 Proteins

CD38 Proteins for Mus musculus (Mouse)

CD38 Proteins for Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)

CD38 Proteins for Rattus norvegicus (Rat)

CD38 Proteins for Oryctolagus cuniculus (Rabbit)

CD38 Proteins for Homo sapiens (Human)

CD38 ELISA Kit

CD38 ELISA Kit for Homo sapiens (Human)

CD38 ELISA Kit for Mus musculus (Mouse)



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