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CD2AP

CD2AP,全稱CD2-associated protein,是一種廣泛存在于細(xì)胞中的蛋白質(zhì)。它最初在外周免疫細(xì)胞中與CD2蛋白相互作用而被發(fā)現(xiàn),后來(lái)研究發(fā)現(xiàn)它與多種細(xì)胞過(guò)程密切相關(guān),包括細(xì)胞骨架重排、細(xì)胞信號(hào)傳導(dǎo)和細(xì)胞內(nèi)吞作用等。CD2AP通過(guò)與多種蛋白相互作用,在細(xì)胞內(nèi)形成一個(gè)復(fù)雜的蛋白質(zhì)網(wǎng)絡(luò),參與調(diào)節(jié)細(xì)胞的形態(tài)和功能。
CD2AP與多種疾病的發(fā)生發(fā)展密切相關(guān),包括阿爾茨海默病、腎病綜合征和某些類型的癌癥等。在阿爾茨海默病中,CD2AP參與淀粉樣蛋白的代謝和tau蛋白的病理過(guò)程,其表達(dá)異常與疾病的發(fā)生發(fā)展密切相關(guān)。在腎病綜合征中,CD2AP表達(dá)異常導(dǎo)致腎小球?yàn)V過(guò)膜結(jié)構(gòu)破壞,引發(fā)腎臟疾病。此外,CD2AP還與某些類型的癌癥的發(fā)生發(fā)展密切相關(guān),例如結(jié)腸癌、乳腺癌和肺癌等。
針對(duì)CD2AP相關(guān)疾病的治療藥物研發(fā)尚處于起步階段。由于CD2AP在多種生理過(guò)程中發(fā)揮重要作用,因此針對(duì)其研發(fā)的藥物需要謹(jǐn)慎選擇作用靶點(diǎn)和作用機(jī)制,以避免產(chǎn)生不良反應(yīng)。未來(lái),隨著對(duì)CD2AP作用機(jī)制的深入研究,相信會(huì)有更多針對(duì)CD2AP相關(guān)疾病的藥物被研發(fā)出來(lái),為患者帶來(lái)新的治療選擇。

熱銷產(chǎn)品

CD2AP Antibody (CSB-PA004914LA01HU)

驗(yàn)證數(shù)據(jù)

CSB-PA004914LA01HU

Western Blot
Positive WB detected in: Rat kidney tissue
All lanes: CD2AP antibody at 11μg/ml
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 72 kDa
Observed band size: 72 kDa

CSB-PA004914LA01HU

IHC image of CSB-PA004914LA01HU diluted at 1:200 and staining in paraffin-embedded human colon cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.

CSB-PA004914LA01HU

Immunofluorescence staining of HepG2 cells with CSB-PA004914LA01HU at 1:66, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).

Human CD2-associated protein(CD2AP) ELISA kit (CSB-EL004914HU)

驗(yàn)證數(shù)據(jù)

CSB-EL004914HU 標(biāo)準(zhǔn)曲線

貨號(hào):CSB-EL004914HU

規(guī)格:96T/48T

靈敏度:4.7 pg/mL

檢測(cè)范圍:18.75 pg/mL-1200 pg/mL

These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.

CD2AP Antibodies

CD2AP for Homo sapiens (Human)

CD2AP Proteins

CD2AP Proteins for Homo sapiens (Human)

CD2AP ELISA Kit

CD2AP ELISA Kit for Homo sapiens (Human)



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