CASP1

CASP1，即半胱天冬酶1，全稱(chēng)為半胱氨酸依賴性天冬氨酸蛋白水解酶1，常用別名有白細(xì)胞介素-1β轉(zhuǎn)換酶（ICE）。它在機(jī)體免疫防御與炎癥調(diào)控中作用關(guān)鍵：當(dāng)細(xì)胞遭遇病原體入侵或損傷刺激時(shí)，會(huì)與其他蛋白形成復(fù)合物，激活后可切割特定細(xì)胞因子前體，使其轉(zhuǎn)化為活性形式釋放到胞外，引發(fā)局部炎癥反應(yīng)以清除病原體；同時(shí)也參與一種快速清除受損細(xì)胞的過(guò)程，防止有害物質(zhì)擴(kuò)散。
CASP1活性失衡，易導(dǎo)致炎癥反應(yīng)過(guò)度或異常，與家族性冷自身炎癥綜合征、周期性發(fā)熱等自身炎癥疾病密切相關(guān)，還被發(fā)現(xiàn)與阿爾茨海默病等神經(jīng)退行性疾病進(jìn)展有關(guān)。目前針對(duì)它的調(diào)控藥物研發(fā)正在推進(jìn)，一些小分子抑制劑已進(jìn)入臨床試驗(yàn)階段，試圖通過(guò)精準(zhǔn)調(diào)節(jié)其活性緩解炎癥相關(guān)疾病癥狀，為患者帶來(lái)新的治療希望。

熱銷(xiāo)產(chǎn)品

Recombinant Human Caspase-1 (CASP1), partial (CSB-EP004543HU2)

驗(yàn)證數(shù)據(jù)

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

CASP1 Recombinant Monoclonal Antibody (CSB-RA957721A0HU)

驗(yàn)證數(shù)據(jù)

Immunocytochemical staining of HT-1080 cells with Caspase 1 antibody. Nuclei were stained blue with DAPI;Caspase 1 was stained magenta with Alexa Fluor? 647. Images were taken using Leica stellaris 5. Protein abundance based on laser Intensity and smart gain: Medium. Scale bar: 20 μm.

Western blotting analysis using Caspase 1 antibody. Total cell lysates (30 μg) from various cell lines were loaded and separated by SDS-PAGE. The blot was incubated with Caspase 1 antibody and HRP-conjugated goat anti-rabbit secondary antibody respectively.

CASP1 Antibody (CSB-PA05824A0Rb)

驗(yàn)證數(shù)據(jù)

Immunohistochemistry of paraffin-embedded human heart tissue using CSB-PA05824A0Rb at dilution of 1:100

Immunohistochemistry of paraffin-embedded human placenta tissue using CSB-PA05824A0Rb at dilution of 1:100

Immunohistochemistry of paraffin-embedded human breast cancer using CSB-PA05824A0Rb at dilution of 1:100

Human Caspase 1(Casp-1) ELISA Kit (CSB-E13025h)

驗(yàn)證數(shù)據(jù)

貨號(hào)：CSB-E13025h

規(guī)格：96T/48T

靈敏度：0.39 ng/ml

檢測(cè)范圍：1.56 ng/ml - 100 ng/ml

These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.

CASP1 Antibody

CASP1 Protein

CASP1 ELISA Kit

CASP1 Antibodies

CASP1 for Homo sapiens (Human)

產(chǎn)品貨號(hào)	產(chǎn)品名稱(chēng)	種屬反應(yīng)性	應(yīng)用類(lèi)型
CSB-PA05824A0Rb	CASP1 Antibody	Human	ELISA, IHC
CSB-PA05824B0Rb	CASP1 Antibody, HRP conjugated	Human	ELISA
CSB-PA001227	CASP1 Antibody	Human,Mouse,Rat	WB, IHC, ELISA
CSB-PA060245	Cleaved-CASP1 (D210) Antibody	Human	WB, IHC, ELISA
CSB-PA060246	Cleaved-CASP1 (M211) Antibody	Human	IHC, ELISA
CSB-PA060247	CASP1 Antibody	Human,Monkey	WB, ELISA
CSB-PA060248	Cleaved-CASP1 (N120) Antibody	Human	WB, ELISA
CSB-PA060249	Phospho-CASP1 (S376) Antibody	Human,Mouse,Rat	WB, IHC, ELISA
CSB-PA758068	CASP1 Antibody	Human	ELISA,WB,IHC
CSB-PA05829A0Rb	CASP1 Antibody	Human	ELISA, IHC, IF
CSB-PA05829B0Rb	CASP1 Antibody, HRP conjugated	Human	ELISA
CSB-PA05829C0Rb	CASP1 Antibody, FITC conjugated	Human
CSB-PA05829D0Rb	CASP1 Antibody, Biotin conjugated	Human	ELISA
CSB-RA957721A0HU	CASP1 Recombinant Monoclonal Antibody	Human, Mouse	ELISA, WB, FC, ICC

CASP1 Proteins

CASP1 Proteins for Rattus norvegicus (Rat)

產(chǎn)品貨號(hào)	產(chǎn)品名稱(chēng)	來(lái)源
CSB-YP004543RA CSB-EP004543RA CSB-BP004543RA CSB-MP004543RA CSB-EP004543RA-B	Recombinant Rat Caspase-1 (Casp1), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

CASP1 Proteins for Homo sapiens (Human)

產(chǎn)品貨號(hào)	產(chǎn)品名稱(chēng)	來(lái)源
CSB-YP004543HU CSB-EP004543HU CSB-BP004543HU CSB-MP004543HU CSB-EP004543HU-B	Recombinant Human Caspase-1 (CASP1), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli
CSB-EP004543HU1	Recombinant Human Caspase-1 (CASP1), partial	E.coli
CSB-EP004543HU2	Recombinant Human Caspase-1 (CASP1), partial	E.coli
CSB-EP004543HU2-B	Recombinant Human Caspase-1 (CASP1), partial, Biotinylated	E.coli

CASP1 Proteins for Mus musculus (Mouse)

產(chǎn)品貨號(hào)	產(chǎn)品名稱(chēng)	來(lái)源
CSB-YP004543MO CSB-EP004543MO CSB-BP004543MO CSB-MP004543MO CSB-EP004543MO-B	Recombinant Mouse Caspase-1 (Casp1), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

CASP1 Proteins for Felis catus (Cat) (Felis silvestris catus)

產(chǎn)品貨號(hào)	產(chǎn)品名稱(chēng)	來(lái)源
CSB-YP868220CA CSB-EP868220CA CSB-BP868220CA CSB-MP868220CA CSB-EP868220CA-B	Recombinant Cat Caspase-1 (CASP1)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

CASP1 Proteins for Arabidopsis thaliana (Mouse-ear cress)

產(chǎn)品貨號(hào)	產(chǎn)品名稱(chēng)	來(lái)源
CSB-YP874426DOA1 CSB-EP874426DOA1 CSB-BP874426DOA1 CSB-MP874426DOA1 CSB-EP874426DOA1-B	Recombinant Arabidopsis thaliana Casparian strip membrane protein 1 (CASP1), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli
CSB-CF874426DOA	Recombinant Arabidopsis thaliana Casparian strip membrane protein 1 (CASP1)	in vitro E.coli expression system

CASP1 Proteins for Equus caballus (Horse)

產(chǎn)品貨號(hào)	產(chǎn)品名稱(chēng)	來(lái)源
CSB-YP874691HO CSB-EP874691HO CSB-BP874691HO CSB-MP874691HO CSB-EP874691HO-B	Recombinant Horse Caspase-1 (CASP1)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

CASP1 Proteins for Canis familiaris (Dog) (Canis lupus familiaris)

產(chǎn)品貨號(hào)	產(chǎn)品名稱(chēng)	來(lái)源
CSB-YP882005DO CSB-EP882005DO CSB-BP882005DO CSB-MP882005DO CSB-EP882005DO-B	Recombinant Dog Caspase-1 (CASP1)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

CASP1 Proteins for Sus scrofa (Pig)

產(chǎn)品貨號(hào)	產(chǎn)品名稱(chēng)	來(lái)源
CSB-YP889025PI CSB-BP889025PI CSB-MP889025PI CSB-EP889025PI-B	Recombinant Pig Caspase-1 (CASP1), partial	Yeast Baculovirus Mammalian cell In Vivo Biotinylation in E.coli