CAGE1
CAGE1，全稱為癌睪抗原1，常見別名有CTAG1B、CT1等。它在正常人體中僅主要于睪丸生殖細(xì)胞表達(dá)，卻在黑色素瘤、非小細(xì)胞肺癌、乳腺癌等多種惡性腫瘤里異常高表達(dá)。這種獨(dú)特的表達(dá)特征讓它成為腫瘤免疫治療的潛力靶點(diǎn)——腫瘤細(xì)胞表面的該蛋白可被免疫系統(tǒng)捕捉，啟動對腫瘤的攻擊反應(yīng)。
CAGE1高表達(dá)常和腫瘤惡性程度、轉(zhuǎn)移傾向及患者差預(yù)后掛鉤，比如黑色素瘤患者中該蛋白陽性率較高，且陽性者復(fù)發(fā)和死亡風(fēng)險(xiǎn)更顯著。目前針對它的治療研究多聚焦免疫領(lǐng)域：基于其抗原肽的腫瘤疫苗已進(jìn)入早期臨床，部分能誘導(dǎo)患者產(chǎn)生特異性T細(xì)胞，抑制腫瘤生長；靶向該蛋白的CAR-T療法也在實(shí)驗(yàn)室研究中見成效，未來或?yàn)橥砥趯?shí)體瘤患者帶來新希望。
熱銷產(chǎn)品
Recombinant Human Cancer-associated gene 1 protein (CAGE1) (CSB-BP837427HU)
驗(yàn)證數(shù)據(jù)
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
驗(yàn)證數(shù)據(jù)
Western blot analysis of extracts from HT-29 cells and Jurkat cells, using CAGE1 antibody.
Immunohistochemistry analysis of paraffin-embedded human breast carcinoma tissue using CAGE1 antibody.
CAGE1 Antibodies
CAGE1 for Homo sapiens (Human)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 種屬反應(yīng)性 | 應(yīng)用類型 |
|---|---|---|---|
| CSB-PA055054 | CAGE1 Antibody | Human | ELISA,WB,IHC |
| CSB-PA001167 | CAGE1 Antibody | Human | WB, IHC, ELISA |
| CSB-PA442042 | CAGE1 Antibody | Human | ELISA,IHC |
| CSB-PA828264 | CAGE1 Antibody | Human | ELISA,IHC |
CAGE1 Proteins
CAGE1 Proteins for Homo sapiens (Human)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP837427HU CSB-EP837427HU CSB-MP837427HU CSB-EP837427HU-B |
Recombinant Human Cancer-associated gene 1 protein (CAGE1) | Yeast E.coli Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-BP837427HU | Recombinant Human Cancer-associated gene 1 protein (CAGE1) | Baculovirus |
