BRS3
BRS3，全稱為Bombesin-like receptor subtype 3，別名BB3、BB3R、BBR3，是一種與鈴蟾肽類似物結(jié)合的G蛋白偶聯(lián)受體。該蛋白主要在睪丸精細(xì)胞、肺腺癌細(xì)胞中表達(dá)，參與精子細(xì)胞分裂、成熟或功能的調(diào)節(jié)。BRS3蛋白通過與G蛋白結(jié)合，激活磷脂酰肌醇-鈣第二信使系統(tǒng)，進(jìn)而影響代謝率、葡萄糖代謝和血壓等生理過程。研究表明，BRS3基因敲除小鼠會(huì)出現(xiàn)肥胖、代謝紊亂和胰島素抵抗，提示該基因在能量穩(wěn)態(tài)中起關(guān)鍵作用。BRS3突變可能導(dǎo)致受體功能喪失或異常，與人類肥胖癥和2型糖尿病風(fēng)險(xiǎn)相關(guān)。過表達(dá)BRS3可能通過增強(qiáng)中樞厭食信號(hào)抑制食欲并改善代謝，而低表達(dá)則可能破壞能量平衡，導(dǎo)致代謝綜合征。BRS3選擇性激動(dòng)劑在動(dòng)物實(shí)驗(yàn)中顯示出抗肥胖潛力，但人類研究仍在探索中。目前，針對(duì)BRS3的藥物研發(fā)主要集中在選擇性激動(dòng)劑和拮抗劑的開發(fā)上，以期用于治療肥胖癥、2型糖尿病等代謝性疾病。
熱銷產(chǎn)品
驗(yàn)證數(shù)據(jù)
Western Blot analysis of HuvEc cells using BRS-3 Polyclonal Antibody
Western Blot analysis of various cells using BRS-3 Polyclonal Antibody
BRS3 Antibodies
BRS3 for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 種屬反應(yīng)性 | 應(yīng)用類型 |
|---|---|---|---|
| CSB-PA001057 | BRS3 Antibody | Human | WB, IF, ELISA |
| CSB-PA050181 | BRS3 Antibody | Human | WB, IHC, IF, ELISA |
| CSB-PA569791 | BRS3 Antibody | Human,Mouse,Rat | ELISA,IHC |
| CSB-PA439979 | BRS3 Antibody | Human,Mouse,Rat | ELISA,WB,IHC |
BRS3 Proteins
BRS3 Proteins for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP002820HU1 CSB-EP002820HU1 CSB-BP002820HU1 CSB-MP002820HU1 CSB-EP002820HU1-B |
Recombinant Human Bombesin receptor subtype-3 (BRS3), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-CF002820HU | Recombinant Human Bombesin receptor subtype-3 (BRS3) | in vitro E.coli expression system |
BRS3 Proteins for Cavia porcellus (Guinea pig)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP002820GU1 CSB-EP002820GU1 CSB-BP002820GU1 CSB-MP002820GU1 CSB-EP002820GU1-B |
Recombinant Guinea pig Bombesin receptor subtype-3 (BRS3), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-CF002820GU | Recombinant Guinea pig Bombesin receptor subtype-3 (BRS3) | in vitro E.coli expression system |
BRS3 Proteins for Mus musculus (Mouse)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP002820MO1 CSB-EP002820MO1 CSB-BP002820MO1 CSB-MP002820MO1 CSB-EP002820MO1-B |
Recombinant Mouse Bombesin receptor subtype-3 (Brs3), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-CF002820MO | Recombinant Mouse Bombesin receptor subtype-3 (Brs3) | in vitro E.coli expression system |
BRS3 Proteins for Ovis aries (Sheep)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP002820SH1 CSB-EP002820SH1 CSB-BP002820SH1 CSB-MP002820SH1 CSB-EP002820SH1-B |
Recombinant Sheep Bombesin receptor subtype-3 (BRS3), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-CF002820SH | Recombinant Sheep Bombesin receptor subtype-3 (BRS3) | in vitro E.coli expression system |
BRS3 Proteins for Macaca mulatta (Rhesus macaque)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP740142MOW1 CSB-EP740142MOW1 CSB-BP740142MOW1 CSB-MP740142MOW1 CSB-EP740142MOW1-B |
Recombinant Macaca mulatta Bombesin receptor subtype-3 (BRS3), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-CF740142MOW | Recombinant Macaca mulatta Bombesin receptor subtype-3 (BRS3) | in vitro E.coli expression system |
BRS3 Proteins for Rattus norvegicus (Rat)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP814322RA1 CSB-EP814322RA1 CSB-BP814322RA1 CSB-MP814322RA1 CSB-EP814322RA1-B |
Recombinant Rat Bombesin receptor subtype-3 (Brs3), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-CF814322RA | Recombinant Rat Bombesin receptor subtype-3 (Brs3) | in vitro E.coli expression system |
