BMX
BMX，全稱骨髓X激酶，是Tec家族酪氨酸激酶成員，在細(xì)胞存活、增殖和分化中發(fā)揮關(guān)鍵作用。該蛋白主要表達(dá)于造血和免疫細(xì)胞，也存在于其他組織和器官。BMX通過(guò)調(diào)控細(xì)胞信號(hào)轉(zhuǎn)導(dǎo)，影響生長(zhǎng)、增殖、遷移等過(guò)程，與炎癥、自身免疫性疾病密切相關(guān)。在炎癥中，BMX調(diào)節(jié)炎癥因子表達(dá)，影響免疫細(xì)胞遷移和浸潤(rùn)；在自身免疫性疾病中，如系統(tǒng)性紅斑狼瘡和類(lèi)風(fēng)濕關(guān)節(jié)炎，BMX的活性和表達(dá)水平變化可能與免疫系統(tǒng)失調(diào)有關(guān)。藥物研發(fā)方面，中科院團(tuán)隊(duì)開(kāi)發(fā)的新型BMX激酶選擇性抑制劑BMX-IN-1，與MK2206組合可顯著抑制前列腺癌細(xì)胞增殖，為抗腫瘤藥物開(kāi)發(fā)奠定基礎(chǔ)。此外，益普生與Biomunex合作開(kāi)發(fā)的BMX-502雙特異性抗體，通過(guò)激活MAIT細(xì)胞并靶向GPC3腫瘤抗原，為治療黏膜相關(guān)腫瘤提供新策略。這些進(jìn)展表明，BMX蛋白及其相關(guān)藥物在疾病治療中具有廣闊前景。
熱銷(xiāo)產(chǎn)品
BMX Antibody (CSB-PA002761ESR1HU)
驗(yàn)證數(shù)據(jù)
Western blot
All lanes: Cytoplasmic tyrosine-protein kinase BMX antibody at 4μg/ml
Lane 1: A549 whole cell lysate
Lane 2: Mouse heart tissue
Secondary
Goat polyclonal to rabbit IgG at 1/10000 dilution
Predicted band size: 78 kDa
Observed band size: 78 kDa
Immunohistochemistry of paraffin-embedded human colon tissue using CSB-PA002761ESR1HU at dilution of 1:100
Immunohistochemistry of paraffin-embedded human placenta tissue using CSB-PA002761ESR1HU at dilution of 1:100
BMX Antibodies
BMX for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 種屬反應(yīng)性 | 應(yīng)用類(lèi)型 |
|---|---|---|---|
| CSB-PA002761ESR2HU | BMX Antibody | Human | ELISA, IHC |
| CSB-PA002761ESR1HU | BMX Antibody | Human, Mouse | ELISA, WB, IHC |
| CSB-PA993762 | Phospho-BMX (Tyr566) Antibody | Human,Mouse | ELISA,WB |
| CSB-PA991678 | BMX Antibody | Human,Mouse | ELISA,WB,IHC,IF |
| CSB-PA001034 | BMX Antibody | Human,Mouse | WB, IHC, IF, ELISA |
| CSB-PA001035 | BMX Antibody | Human,Mouse | WB, IHC, IF, ELISA |
| CSB-PA001036 | BMX Antibody | Human,Mouse,Monkey | WB, IHC, IF, ELISA |
| CSB-PA050105 | Phospho-BMX (Y566) Antibody | Human,Mouse | WB, IHC, ELISA |
| CSB-PA050106 | Phospho-BMX (Y40) Antibody | Human,Mouse | WB, IHC, IF, ELISA |
| CSB-PA229873 | BMX Antibody | Human,Mouse | ELISA,IHC |
| CSB-PA979712 | BMX Antibody | Human,Mouse | ELISA,IHC |
BMX Proteins
BMX Proteins for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來(lái)源 |
|---|---|---|
| CSB-YP002761HU CSB-EP002761HU CSB-BP002761HU CSB-MP002761HU CSB-EP002761HU-B |
Recombinant Human Cytoplasmic tyrosine-protein kinase BMX (BMX) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
