BAG3
BAG3，即Bcl2相關(guān)永生基因3，別名CAIR-1/Bis/MFM6。它是一種由人類BAG3基因編碼的蛋白質(zhì)，屬于BAG家族蛋白。BAG3在多種細(xì)胞過程中發(fā)揮作用，包括細(xì)胞凋亡、發(fā)育、細(xì)胞骨架組織和自噬。其作用機(jī)制涉及與熱休克蛋白70(Hsp70)的ATP酶結(jié)構(gòu)域相互作用，通過BAG結(jié)構(gòu)域，以及與其他蛋白質(zhì)的相互作用，如通過WW結(jié)構(gòu)域和PXXP結(jié)構(gòu)域。BAG3通過調(diào)節(jié)這些途徑，介導(dǎo)細(xì)胞對(duì)應(yīng)激刺激的適應(yīng)性反應(yīng)，其表達(dá)失調(diào)可能導(dǎo)致多種腫瘤的發(fā)生。BAG3還與擴(kuò)張型心肌病(DCM)相關(guān)，其基因突變可能是DCM的新病因。
熱銷產(chǎn)品
驗(yàn)證數(shù)據(jù)
Western blot analysis of extracts from 293 cells, using BAG3 antibody.
Immunohistochemistry analysis of paraffin-embedded human liver carcinoma tissue, using BAG3 antibody.
BAG3 Antibodies
BAG3 for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 種屬反應(yīng)性 | 應(yīng)用類型 |
|---|---|---|---|
| CSB-PA002531GA01HU | BAG3 Antibody | Human,Mouse,Rat | ELISA,WB |
| CSB-PA644586 | BAG3 Antibody | Human | ELISA,WB,IHC |
| CSB-PA006106 | BAG3 Antibody | Human | WB, ELISA |
| CSB-PA080018 | BAG3 Antibody | Human,Mouse,Rat | WB, IHC, ELISA |
| CSB-PA056537 | BAG3 Antibody | Human,Mouse | ELISA,WB,IHC |
| CSB-PA245428 | BAG3 Antibody | Human,Mouse | ELISA,WB,IHC |
| CSB-RA002531A0HU | BAG3 Recombinant Monoclonal Antibody | Human | ELISA, WB, IHC |
| CSB-PA002531LA01HU | BAG3 Antibody | Human | ELISA, IHC, IF |
| CSB-PA002531LB01HU | BAG3 Antibody,HRP conjugated | Human | ELISA |
| CSB-PA002531LC01HU | BAG3 Antibody，F(xiàn)ITC conjugated | Human |
BAG3 Proteins
BAG3 Proteins for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP002531HU CSB-EP002531HU CSB-BP002531HU CSB-MP002531HU CSB-EP002531HU-B |
Recombinant Human BAG family molecular chaperone regulator 3 (BAG3) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
