BAG2
BAG2，全稱(chēng)為Bcl-2相關(guān)抗凋亡基因2，它屬于BAG蛋白家族，通過(guò)其BAG結(jié)構(gòu)域與熱休克蛋白70（Hsp70）相互作用，共同參與蛋白質(zhì)折疊、降解和抗凋亡等過(guò)程。研究表明，BAG2能通過(guò)調(diào)節(jié)tau蛋白的降解途徑影響其聚集，與阿爾茨海默病等神經(jīng)退行性疾病相關(guān)——BAG2表達(dá)降低會(huì)導(dǎo)致tau蛋白異常積累，形成神經(jīng)纖維纏結(jié)；而過(guò)表達(dá)BAG2則可增強(qiáng)細(xì)胞清除錯(cuò)誤折疊蛋白的能力。此外，BAG2還參與調(diào)控自噬過(guò)程，其表達(dá)水平變化會(huì)影響細(xì)胞應(yīng)對(duì)應(yīng)激的能力。在癌癥中，BAG2可能發(fā)揮雙重作用：一方面其抗凋亡特性可能促進(jìn)腫瘤細(xì)胞存活，另一方面它維持蛋白質(zhì)穩(wěn)態(tài)的功能可能抑制致癌蛋白的積累。BAG2基因突變可能導(dǎo)致其與Hsp70相互作用異常，進(jìn)而引發(fā)蛋白質(zhì)折疊疾病。該基因的表達(dá)受多種轉(zhuǎn)錄因子調(diào)控，并與多種神經(jīng)退行性疾病、癌癥及心血管疾病的發(fā)病機(jī)制相關(guān)。目前，針對(duì)BAG2的藥物研發(fā)主要集中在開(kāi)發(fā)特異性結(jié)合BAG2的抗體或抑制劑，以抑制其抗凋亡活性或調(diào)節(jié)其與Hsp70的相互作用，從而抑制腫瘤細(xì)胞的生長(zhǎng)和轉(zhuǎn)移。
熱銷(xiāo)產(chǎn)品
Recombinant Human BAG family molecular chaperone regulator 2 (BAG2) (CSB-EP002530HU)
驗(yàn)證數(shù)據(jù)
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
BAG2 Recombinant Monoclonal Antibody (CSB-RA104772A0HU)
驗(yàn)證數(shù)據(jù)
Western Blot
Positive WB detected in: Hela whole cell lysate(30μg), Jurkat whole cell lysate(30μg), PC-3 whole cell lysate(30μg)
All lanes: BAG2 antibody at 1:1000
Secondary
Goat polyclonal to rabbit IgG at 1/40000 dilution
Predicted band size: 24 kDa
Observed band size: 24 kDa
Exposure time：1min
BAG2 Antibody (CSB-PA002530ESR1HU)
驗(yàn)證數(shù)據(jù)
Western blot
All lanes: BAG family molecular chaperone regulator 2 antibody at 6μg/ml
Lane 1: Jurkat whole cell lysate
Lane 2: Hela whole cell lysate
Lane 3: HepG2 whole cell lysate
Secondary
Goat polyclonal to rabbit IgG at 1/10000 dilution
Predicted band size: 24, 21 kDa
Observed band size: 24 kDa
Immunohistochemistry of paraffin-embedded human ovarian cancer using CSB-PA002530ESR1HU at dilution of 1:100
Immunohistochemistry of paraffin-embedded human kidney tissue using CSB-PA002530ESR1HU at dilution of 1:100
BAG2 Antibodies
BAG2 for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱(chēng) | 種屬反應(yīng)性 | 應(yīng)用類(lèi)型 |
|---|---|---|---|
| CSB-PA002530ESR1HU | BAG2 Antibody | Human | ELISA, WB, IHC |
| CSB-RA104772A0HU | BAG2 Recombinant Monoclonal Antibody | Human | ELISA, WB |
BAG2 Proteins
BAG2 Proteins for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱(chēng) | 來(lái)源 |
|---|---|---|
| CSB-YP002530HU CSB-BP002530HU CSB-MP002530HU CSB-EP002530HU-B |
Recombinant Human BAG family molecular chaperone regulator 2 (BAG2) | Yeast Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-EP002530HU | Recombinant Human BAG family molecular chaperone regulator 2 (BAG2) | E.coli |
BAG2 Proteins for Arabidopsis thaliana (Mouse-ear cress)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱(chēng) | 來(lái)源 |
|---|---|---|
| CSB-YP604500DOA CSB-EP604500DOA CSB-BP604500DOA CSB-MP604500DOA CSB-EP604500DOA-B |
Recombinant Arabidopsis thaliana BAG family molecular chaperone regulator 2 (BAG2) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
BAG2 Proteins for Mus musculus (Mouse)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱(chēng) | 來(lái)源 |
|---|---|---|
| CSB-YP835596MO CSB-EP835596MO CSB-BP835596MO CSB-MP835596MO CSB-EP835596MO-B |
Recombinant Mouse BAG family molecular chaperone regulator 2 (Bag2) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
