BACE1
BACE1，即β-分泌酶1，別名BACE、KIAA1149、ASP2，它主要來源于11號染色體上的基因。BACE1是一種天冬氨酸蛋白酶，其作用機(jī)制是通過剪切淀粉樣前體蛋白（APP），產(chǎn)生β-淀粉樣蛋白（Aβ），這一過程在阿爾茨海默病（AD）的發(fā)病中起到關(guān)鍵作用。此外，BACE1還涉及心血管代謝疾病的發(fā)生發(fā)展，如糖尿病和動脈粥樣硬化。作為重要的生物學(xué)靶點(diǎn)，BACE1的抑制劑已被研發(fā)用于AD治療，并展現(xiàn)出對代謝性疾病的潛在治療效果。盡管其確切的生物學(xué)意義和全部功能仍在深入研究中，但BACE1已成為神經(jīng)科學(xué)和藥物研發(fā)領(lǐng)域的熱點(diǎn)之一。
熱銷產(chǎn)品
BACE1 Recombinant Monoclonal Antibody (CSB-RA177574A0HU)
驗證數(shù)據(jù)
Western Blot
Positive WB detected in: MCF-7 whole cell lysate, Rat brain tissue, Mouse brain tissue
All lanes: BACE1 antibody at 1:2000
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 56, 53, 52, 49, 46, 43 kDa
Observed band size: 72 kDa
Human β-site APP-Cleaving Enzyme 1,BACE1 ELISA kit (CSB-E09824h)
驗證數(shù)據(jù)
貨號：CSB-E09824h
規(guī)格：96T/48T
靈敏度：0.78 pg/mL
檢測范圍：3.12 pg/mL-200 pg/mL
These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.
BACE1 Antibodies
BACE1 for Homo sapiens (Human)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 種屬反應(yīng)性 | 應(yīng)用類型 |
|---|---|---|---|
| CSB-PA002524GA01HU | BACE1 Antibody | Human,Mouse,Rat | ELISA,WB |
| CSB-PA008418 | BACE1 Antibody | Human,Mouse,Rat | IHC, IF, ELISA |
| CSB-PA173556 | BACE1 Antibody | Human,Mouse,Rat | ELISA,IHC |
| CSB-PA150463 | BACE1 Antibody | Human,Mouse,Rat | ELISA,WB |
| CSB-PA002524LA01HU | BACE1 Antibody | Human | ELISA, IHC, IF |
| CSB-PA002524LB01HU | BACE1 Antibody, HRP conjugated | Human | ELISA |
| CSB-PA002524LC01HU | BACE1 Antibody, FITC conjugated | Human | |
| CSB-PA002524LD01HU | BACE1 Antibody, Biotin conjugated | Human | ELISA |
| CSB-RA177574A0HU | BACE1 Recombinant Monoclonal Antibody | Human, Mouse, Rat | ELISA, WB |
BACE1 Proteins
BACE1 Proteins for Homo sapiens (Human)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP002524HU1 CSB-EP002524HU1 CSB-BP002524HU1 CSB-MP002524HU1 CSB-EP002524HU1-B |
Recombinant Human Beta-secretase 1 (BACE1), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-CF002524HU | Recombinant Human Beta-secretase 1 (BACE1) | in vitro E.coli expression system |
BACE1 ELISA Kit
BACE1 ELISA Kit for Homo sapiens (Human)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 樣本類型 | 靈敏度 |
|---|---|---|---|
| CSB-E09824h | Human β-site APP-Cleaving Enzyme 1,BACE1 ELISA kit | serum, plasma, tissue homogenates | 0.78 pg/mL |
