ARIH2
ARIH2，全稱為Ariadne RBR E3泛素蛋白連接酶2，是一種參與蛋白質(zhì)降解的重要酶。該蛋白在多種組織中廣泛表達(dá)，尤其在甲狀腺和心臟中表達(dá)量較高。ARIH2蛋白能夠?qū)⒎核胤肿舆B接到目標(biāo)蛋白質(zhì)上，從而標(biāo)記這些蛋白質(zhì)進(jìn)行降解。這一過程對(duì)于細(xì)胞內(nèi)蛋白質(zhì)穩(wěn)態(tài)的維持至關(guān)重要。研究表明，ARIH2蛋白上調(diào)某些癌細(xì)胞中的p53蛋白表達(dá)，并可能抑制骨髓細(xì)胞生成。此外，ARIH2蛋白還與免疫系統(tǒng)的功能密切相關(guān)，其在樹突狀細(xì)胞中能夠促進(jìn)免疫反應(yīng)的調(diào)節(jié)。目前，針對(duì)ARIH2蛋白的藥物研發(fā)尚處于早期階段，但其在癌癥和免疫系統(tǒng)疾病治療中具有巨大的潛力。
熱銷產(chǎn)品
ARIH2 Antibody (CSB-PA002069LA01HU)
驗(yàn)證數(shù)據(jù)
Western Blot
Positive WB detected in: HEK293 whole cell lysate, Hela whole cell lysate, Jurkat whole cell lysate, Mouse heart tissue, Mouse liver tissue, Mouse brain tissue
All lanes: ARIH2 antibody at 3μg/ml
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 58 kDa
Observed band size: 58 kDa
Immunohistochemistry of paraffin-embedded human lymph node tissue using CSB-PA002069LA01HU at dilution of 1:100
Western Blot
Positive WB detected in: 293 whole cell lysate, Hela whole cell lysate, 293T whole cell lysate, Jurkat whole cell lysate, K562 whole cell lysate, U251 whole cell lysate, PC-3 whole cell lysate, Mouse kidney tissue, Mouse brain tissue
All lanes: ARIH2 antibody at 1:2000
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 58 kDa
Observed band size: 68 kDa
ARIH2 Antibodies
ARIH2 for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 種屬反應(yīng)性 | 應(yīng)用類型 |
|---|---|---|---|
| CSB-PA002069GA01HU | ARIH2 Antibody | Human,Mouse,Rat | ELISA,WB |
| CSB-PA240267 | ARIH2 Antibody | Human,Mouse | ELISA,WB |
| CSB-PA002069ESR1HU | ARIH2 Antibody | Human | ELISA, IHC |
| CSB-PA002069LA01HU | ARIH2 Antibody | Human, Mouse | ELISA, WB, IHC |
ARIH2 Proteins
ARIH2 Proteins for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP002069HU CSB-EP002069HU CSB-BP002069HU CSB-MP002069HU CSB-EP002069HU-B |
Recombinant Human E3 ubiquitin-protein ligase ARIH2 (ARIH2) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
