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ARID5B

Transcription coactivator that binds to the 5'-AATA[CT]-3' core sequence and plays a key role in adipogenesis and liver development. Acts by forming a complex with phosphorylated PHF2, which mediates demethylation at Lys-336, leading to target the PHF2-ARID5B complex to target promoters, where PHF2 mediates demethylation of dimethylated 'Lys-9' of histone H3 (H3K9me2), followed by transcription activation of target genes. The PHF2-ARID5B complex acts as a coactivator of HNF4A in liver. Required for adipogenesis: regulates triglyceride metabolism in adipocytes by regulating expression of adipogenic genes. Overexpression leads to induction of smooth muscle marker genes, suggesting that it may also act as a regulator of smooth muscle cell differentiation and proliferation. Represses the cytomegalovirus enhancer.

ARID5B Proteins

ARID5B Proteins for Bos taurus (Bovine)

ARID5B Proteins for Canis familiaris (Dog) (Canis lupus familiaris)

ARID5B Proteins for Danio rerio (Zebrafish) (Brachydanio rerio)

ARID5B Proteins for Homo sapiens (Human)

ARID5B Proteins for Gallus gallus (Chicken)

ARID5B Proteins for Mus musculus (Mouse)



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