APLNR
APLNR蛋白，全稱Apelin受體，是一種G蛋白偶聯(lián)受體，常見別名包括APJ受體。該蛋白主要由內(nèi)源性配體Apelin驅(qū)動(dòng)，參與多種生理病理過(guò)程。Apelin與APLNR結(jié)合后，可激活下游多種信號(hào)通路，如G蛋白和β-arrestin信號(hào)通路，從而調(diào)節(jié)血管舒張、正性肌力、血管生成、利尿、降低血壓等生理功能。APLNR在心血管系統(tǒng)中發(fā)揮重要作用，其激活可抑制心肌纖維化、減輕病理性心肌肥厚、抵抗心力衰竭和肺動(dòng)脈高壓等。研究表明，APLNR的G蛋白信號(hào)通路對(duì)心臟保護(hù)效應(yīng)至關(guān)重要，而β-arrestin信號(hào)通路則可能引起有害的心肌肥厚。因此，開發(fā)選擇性激活G蛋白信號(hào)通路的APLNR激動(dòng)劑，有望成為治療心血管疾病的新策略。目前，多家國(guó)際知名藥企和科研機(jī)構(gòu)正致力于開發(fā)有效的APLNR激動(dòng)劑類藥物，部分已進(jìn)入臨床研究階段，但尚未有靶向該受體的分子成功獲批上市。
熱銷產(chǎn)品
APLNR Antibody (CSB-PA001910EA01HU)
驗(yàn)證數(shù)據(jù)
Immunohistochemistry of paraffin-embedded human colon cancer using CSB-PA001910EA01HU at dilution of 1:100
Immunofluorescent analysis of A431 cells using CSB-PA001910EA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
Human Apelin receptor(APLNR) ELISA kit (CSB-EL001910HU)
驗(yàn)證數(shù)據(jù)
貨號(hào)：CSB-EL001910HU
規(guī)格：96T/48T
靈敏度：5.8 pg/mL
檢測(cè)范圍：23.5 pg/mL-1500 pg/mL
These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.
APLNR Antibodies
APLNR for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 種屬反應(yīng)性 | 應(yīng)用類型 |
|---|---|---|---|
| CSB-PA007868 | APLNR Antibody | Human | WB, IHC, IF, ELISA |
| CSB-PA963250 | APLNR Antibody | Human,Mouse,Rat | ELISA,WB,IHC |
| CSB-PA229044 | APLNR Antibody | Human,Mouse,Rat | ELISA,IHC |
| CSB-PA165028 | APLNR Antibody | Human,Mouse,Rat | ELISA,IHC |
| CSB-PA001910EA01HU | APLNR Antibody | Human | ELISA, IHC, IF |
APLNR Proteins
APLNR Proteins for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來(lái)源 |
|---|---|---|
| CSB-YP001910HU1 CSB-EP001910HU1 CSB-BP001910HU1 CSB-MP001910HU1 CSB-EP001910HU1-B |
Recombinant Human Apelin receptor (APLNR), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-CF001910HU | Recombinant Human Apelin receptor (APLNR) | in vitro E.coli expression system |
APLNR Proteins for Macaca mulatta (Rhesus macaque)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來(lái)源 |
|---|---|---|
| CSB-YP001910MOW1 CSB-EP001910MOW1 CSB-BP001910MOW1 CSB-MP001910MOW1 CSB-EP001910MOW1-B |
Recombinant Macaca mulatta Apelin receptor (APLNR), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-CF001910MOW | Recombinant Macaca mulatta Apelin receptor (APLNR) | in vitro E.coli expression system |
APLNR Proteins for Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來(lái)源 |
|---|---|---|
| CSB-YP001910XBF1 CSB-EP001910XBF1 CSB-BP001910XBF1 CSB-MP001910XBF1 CSB-EP001910XBF1-B |
Recombinant Xenopus tropicalis Apelin receptor (aplnr), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-CF001910XBF | Recombinant Xenopus tropicalis Apelin receptor (aplnr) | in vitro E.coli expression system |
APLNR Proteins for Rattus norvegicus (Rat)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來(lái)源 |
|---|---|---|
| CSB-YP001910RA1 CSB-EP001910RA1 CSB-BP001910RA1 CSB-MP001910RA1 CSB-EP001910RA1-B |
Recombinant Rat Apelin receptor (Aplnr), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-CF001910RA | Recombinant Rat Apelin receptor (Aplnr) | in vitro E.coli expression system |
APLNR Proteins for Mus musculus (Mouse)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來(lái)源 |
|---|---|---|
| CSB-YP001910MO1 CSB-BP001910MO1 CSB-MP001910MO1 CSB-EP001910MO1-B |
Recombinant Mouse Apelin receptor (Aplnr), partial | Yeast Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-CF001910MO | Recombinant Mouse Apelin receptor (Aplnr) | in vitro E.coli expression system |
| CSB-EP001910MO1 | Recombinant Mouse Apelin receptor (Aplnr), partial | E.coli |
APLNR ELISA Kit
APLNR ELISA Kit for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 樣本類型 | 靈敏度 |
|---|---|---|---|
| CSB-EL001910HU | Human Apelin receptor(APLNR) ELISA kit | serum, plasma, tissue homogenates, cell lysates | 5.8 pg/mL |
