ANO6
ANO6，全稱為ANOCTAMIN 6，常用別名是TMEM16F。這個(gè)蛋白在細(xì)胞活動(dòng)中扮演關(guān)鍵角色，比如血小板被激活時(shí)，它能推動(dòng)細(xì)胞膜內(nèi)側(cè)的磷脂分子翻轉(zhuǎn)到外側(cè)，為凝血因子的聚集提供條件，助力正常的止血過程。ANO6功能出現(xiàn)異常，可能導(dǎo)致凝血環(huán)節(jié)受阻——像Scott綜合征患者就常因ANO6突變，出現(xiàn)血小板磷脂翻轉(zhuǎn)障礙，表現(xiàn)為出血風(fēng)險(xiǎn)升高，創(chuàng)傷或手術(shù)后止血困難。
在藥物研發(fā)領(lǐng)域，針對(duì)ANO6的調(diào)節(jié)藥物正受到關(guān)注：抑制它的化合物或許能減少不必要的血栓形成，有望用于血栓類疾病的治療。
熱銷產(chǎn)品
ANO6 Antibody (CSB-PA679761LA01HU)
驗(yàn)證數(shù)據(jù)
Immunofluorescence staining of HepG2 cells with CSB-PA679761LA01HU at 1:100, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
ANO6 Antibodies
ANO6 for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 種屬反應(yīng)性 | 應(yīng)用類型 |
|---|---|---|---|
| CSB-PA679761LA01HU | ANO6 Antibody | Human | ELISA, IF |
| CSB-PA679761LB01HU | ANO6 Antibody, HRP conjugated | Human | ELISA |
ANO6 Proteins
ANO6 Proteins for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP679761HU CSB-EP679761HU CSB-BP679761HU CSB-MP679761HU CSB-EP679761HU-B |
Recombinant Human Anoctamin-6 (ANO6), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
ANO6 Proteins for Mus musculus (Mouse)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP750831MO CSB-EP750831MO CSB-BP750831MO CSB-MP750831MO CSB-EP750831MO-B |
Recombinant Mouse Anoctamin-6 (Ano6), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
