ALPL

ALPL（組織非特異性堿性磷酸酶，TNSALP）是一種廣泛存在于人體多種組織中的膜結(jié)合糖蛋白，具有多種生理功能。它是一種同源二聚體酶，由不同基因位點編碼，每個催化位點包含兩個鋅離子和一個鎂離子。ALPL在骨骼礦化過程中起到關(guān)鍵作用，通過水解有機(jī)磷酸酯和去除無機(jī)焦磷酸(PPi)來促進(jìn)正常骨骼的形成和維護(hù)。此外，它還參與胚胎發(fā)育、細(xì)胞生長、細(xì)胞凋亡和細(xì)胞遷移等細(xì)胞事件的調(diào)節(jié)。盡管具體的信號通路未明確提及，但ALPL的功能表明它可能參與骨骼礦化、細(xì)胞信號傳導(dǎo)和細(xì)胞凋亡等信號通路。ALPL的異常表達(dá)或功能失調(diào)與多種疾病相關(guān)，如遺傳性低磷酸酯酶癥、某些類型的癌癥以及骨骼和牙齒的疾病，使其成為醫(yī)學(xué)研究中的關(guān)鍵靶點。

熱銷產(chǎn)品

ALPL Antibody (CSB-PA11999A0Rb)

驗證數(shù)據(jù)

IHC image of CSB-PA11999A0Rb diluted at 1:100 and staining in paraffin-embedded human ovarian cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.

ALPL Antibody

ALPL ELISA Kit

ALPL Antibodies

ALPL for Homo sapiens (Human)

產(chǎn)品貨號	產(chǎn)品名稱	種屬反應(yīng)性	應(yīng)用類型
CSB-PA001631GA01HU	ALPL Antibody	Human,Mouse,Rat	ELISA,WB,IHC
CSB-PA11999A0Rb	ALPL Antibody	Human	ELISA, IHC
CSB-PA11999D0Rb	ALPL Antibody, Biotin conjugated	Human	ELISA
CSB-PA177961	ALPL Antibody	Human	ELISA,WB
CSB-PA001631ESR2HU	ALPL Antibody	Human	ELISA, IHC
CSB-PA006129	ALPL Antibody	Human,Rat	WB, ELISA
CSB-PA008482	ALPL Antibody	Human,Mouse,Rat	WB, ELISA
CSB-PA034215	ALPL Antibody	Human,Mouse,Rat	ELISA,IHC
CSB-PA228295	ALPL Antibody	Human,Mouse,Rat	ELISA,IHC