ALDH1B1
ALDH1B1，全稱為乙醛脫氫酶1家族成員B1，暫時(shí)沒(méi)有被廣泛熟知的特殊別名。它是乙醛脫氫酶家族里的重要一員，主要負(fù)責(zé)體內(nèi)醛類物質(zhì)的代謝轉(zhuǎn)化——把有毒的乙醛分解成無(wú)害的乙酸，在肝臟這類代謝活躍的器官中，承擔(dān)著解毒和調(diào)節(jié)能量代謝的關(guān)鍵角色。
ALDH1B1表達(dá)異常和不少疾病有關(guān)聯(lián)：長(zhǎng)期喝酒的人如果它活性不夠，乙醛在身體里堆積會(huì)加重肝臟損傷，提高酒精性肝病的發(fā)病風(fēng)險(xiǎn)；在結(jié)直腸癌、肝癌等腫瘤中，它的高表達(dá)常常和腫瘤細(xì)胞增殖快、耐藥性強(qiáng)聯(lián)系在一起，是潛在的腫瘤進(jìn)展標(biāo)志物。目前針對(duì)ALDH1B1的藥物研發(fā)主要集中在腫瘤靶向治療方向，一些小分子抑制劑被嘗試用來(lái)阻斷它的功能，希望能抑制腫瘤細(xì)胞生長(zhǎng)，但相關(guān)臨床試驗(yàn)還在探索階段，還沒(méi)有成熟的藥物獲批上市。
熱銷(xiāo)產(chǎn)品
ALDH1B1 Antibody (CSB-PA001568ESR1HU)
驗(yàn)證數(shù)據(jù)
Western blot
All lanes: Aldehyde dehydrogenase X, mitochondrial antibody at 4μg/ml
Lane 1: Hela whole cell lysate
Lane 2: Rat brain tissue
Lane 3: HepG2 whole cell lysate
Secondary
Goat polyclonal to rabbit IgG at 1/10000 dilution
Predicted band size: 57 kDa
Observed band size: 57 kDa
Immunohistochemistry of paraffin-embedded human breast cancer using CSB-PA001568ESR1HU at dilution of 1:100
Immunohistochemistry of paraffin-embedded human testis tissue using CSB-PA001568ESR1HU at dilution of 1:100
ALDH1B1 Antibodies
ALDH1B1 for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 種屬反應(yīng)性 | 應(yīng)用類型 |
|---|---|---|---|
| CSB-PA001568GA01HU | ALDH1B1 Antibody | Human,Mouse,Rat | ELISA,WB,IHC |
| CSB-PA001568ESR1HU | ALDH1B1 Antibody | Human, Rat | ELISA, WB, IHC |
| CSB-PA900038 | ALDH1B1 Antibody | Human | ELISA,WB |
| CSB-PA000860 | ALDH1B1 Antibody | Human,Monkey | WB, ELISA |
| CSB-PA942262 | ALDH1B1 Antibody | Human | ELISA,WB |
ALDH1B1 Proteins
ALDH1B1 Proteins for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來(lái)源 |
|---|---|---|
| CSB-YP001568HU CSB-EP001568HU CSB-BP001568HU CSB-MP001568HU CSB-EP001568HU-B |
Recombinant Human Aldehyde dehydrogenase X, mitochondrial (ALDH1B1) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-EP001568HU1 | Recombinant Human Aldehyde dehydrogenase X, mitochondrial (ALDH1B1), partial | E.coli |
