ALDH1A1
ALDH1A1，即醛脫氫酶1家族成員A1，別名ALDC、ALDH1、HEL-9、HEL12、PUMB1、ALDH11、RALDH1、ALDH-E1、HEL-S-53e等。它是由人類(lèi)基因組編碼的一種酶，主要在肝臟、十二指腸和胃等組織中表達(dá)。ALDH1A1的作用機(jī)制是通過(guò)其催化活性將視黃醛氧化成視黃酸，這一過(guò)程在維生素A類(lèi)物質(zhì)代謝中起著關(guān)鍵作用，同時(shí)在維持細(xì)胞內(nèi)穩(wěn)態(tài)、保護(hù)細(xì)胞免受活性醛的毒性中也非常重要。ALDH1A1不僅參與正常生理過(guò)程，如視覺(jué)循環(huán)和細(xì)胞分化，還與多種疾病的發(fā)生發(fā)展相關(guān)，包括代謝性疾病、神經(jīng)退行性疾病以及腫瘤。ALDH1A1的異常表達(dá)與腫瘤干細(xì)胞特性的維持、代謝重塑、DNA修復(fù)能力的提升有關(guān)，是腫瘤治療中一個(gè)重要的靶標(biāo)。此外，ALDH1A1在腫瘤細(xì)胞中的高表達(dá)可能導(dǎo)致化療耐藥性，在癌癥治療中，ALDH1A1抑制劑的研發(fā)具有重要意義。
熱銷(xiāo)產(chǎn)品
ALDH1A1 Antibody (CSB-PA001565ESR1HU)
驗(yàn)證數(shù)據(jù)
Western blot
All lanes: Retinal dehydrogenase 1 antibody at 4μg/ml + Mouse liver tissue
Secondary
Goat polyclonal to rabbit IgG at 1/10000 dilution
Predicted band size: 55 kDa
Observed band size: 55 kDa
Immunohistochemistry of paraffin-embedded human small intestine tissue using CSB-PA001565ESR1HU at dilution of 1:100
Immunohistochemistry of paraffin-embedded human testis tissue using CSB-PA001565ESR1HU at dilution of 1:100
ALDH1A1 Antibodies
ALDH1A1 for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱(chēng) | 種屬反應(yīng)性 | 應(yīng)用類(lèi)型 |
|---|---|---|---|
| CSB-PA001565GA01HU | ALDH1A1 Antibody | Human,Mouse,Rat | ELISA,WB,IHC |
| CSB-PA001565ESR1HU | ALDH1A1 Antibody | Human, Mouse | ELISA, WB, IHC |
| CSB-PA004982 | ALDH1A1 Antibody | Human | WB, ELISA |
ALDH1A1 Proteins
ALDH1A1 Proteins for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱(chēng) | 來(lái)源 |
|---|---|---|
| CSB-YP001565HU CSB-EP001565HU CSB-BP001565HU CSB-MP001565HU CSB-EP001565HU-B |
Recombinant Human Retinal dehydrogenase 1 (ALDH1A1) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
