AKR1B10
AKR1B10，全稱為醛酮還原酶家族1成員B10，在多種組織中均有表達，但在小腸、結(jié)腸和腎上腺中表達量最高。該蛋白能夠有效還原脂肪族和芳香族醛，對己糖的活性較低，可能在肝臟腫瘤發(fā)生中發(fā)揮重要作用。AKR1B10蛋白的表達與多種疾病相關(guān)，包括肝癌、肺癌、乳腺癌和結(jié)腸癌等。近年來，AKR1B10蛋白作為肝癌診斷標(biāo)志物的應(yīng)用研究取得了顯著進展。研究表明，AKR1B10蛋白作為肝癌血清標(biāo)志物，其性能優(yōu)于傳統(tǒng)的甲胎蛋白（AFP），具有更高的靈敏度和特異性，能夠更早地發(fā)現(xiàn)早期肝癌患者。此外，AKR1B10蛋白的表達也與結(jié)直腸癌肝轉(zhuǎn)移密切相關(guān)。研究發(fā)現(xiàn)，AKR1B10蛋白在結(jié)直腸癌中低表達，其缺失會導(dǎo)致活性氧水平上升，進而誘導(dǎo)蛋白磷酸酶2A（PP2A）的調(diào)節(jié)亞基B56α硝基化，抑制PP2A活性，增強c-Myc蛋白穩(wěn)定性，激活下游整合素信號通路，促進腫瘤細(xì)胞轉(zhuǎn)移?；贏KR1B10蛋白的這些特性，研究人員正在開發(fā)針對AKR1B10蛋白的藥物，以期用于肝癌和結(jié)直腸癌的診斷和治療。
熱銷產(chǎn)品
Recombinant Human Aldo-keto reductase family 1 member B10 (AKR1B10) (K125L) (CSB-EP001540HU(M))
驗證數(shù)據(jù)
-SDS.jpg)
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
AKR1B10 Antibody (CSB-PA001540ESR2HU)
驗證數(shù)據(jù)
Western blot
All lanes: AKR1B10 antibody at 4µg/ml + A549 whole cell lysate
Secondary
Goat polyclonal to rabbit IgG at 1/10000 dilution
Predicted band size: 36 kDa
Observed band size: 36 kDa
Immunohistochemistry of paraffin-embedded human small intestine tissue using CSB-PA001540ESR2HU at dilution of 1:100
Immunohistochemistry of paraffin-embedded human kidney tissue using CSB-PA001540ESR2HU at dilution of 1:100
Human Aldo-keto reductase family 1 member B10(AKR1B10) ELISA kit (CSB-EL001540HU)
驗證數(shù)據(jù)
貨號：CSB-EL001540HU
規(guī)格：96T/48T
靈敏度：0.156 ng/mL
檢測范圍：0.625 ng/mL-40 ng/mL
These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.
AKR1B10 Antibodies
AKR1B10 for Homo sapiens (Human)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 種屬反應(yīng)性 | 應(yīng)用類型 |
|---|---|---|---|
| CSB-PA001540ESR2HU | AKR1B10 Antibody | Human | ELISA, WB, IHC |
| CSB-PA298726 | AKR1B10 Antibody | Human | ELISA,WB,IHC |
| CSB-PA918257 | AKR1B10 Antibody | Human | ELISA,WB,IHC |
AKR1B10 Proteins
AKR1B10 Proteins for Homo sapiens (Human)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP001540HU CSB-BP001540HU CSB-MP001540HU CSB-EP001540HU-B |
Recombinant Human Aldo-keto reductase family 1 member B10 (AKR1B10) | Yeast Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-EP001540HU | Recombinant Human Aldo-keto reductase family 1 member B10 (AKR1B10) | E.coli |
| CSB-EP001540HU(M) | Recombinant Human Aldo-keto reductase family 1 member B10 (AKR1B10) (K125L) | E.coli |
AKR1B10 ELISA Kit
AKR1B10 ELISA Kit for Homo sapiens (Human)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 樣本類型 | 靈敏度 |
|---|---|---|---|
| CSB-EL001540HU | Human Aldo-keto reductase family 1 member B10(AKR1B10) ELISA kit | serum, plasma, tissue homogenates | 0.156 ng/mL |
