ADGRA1 is a gene encoding a protein named adhesion G protein-coupled receptor A1 or G-protein coupled receptor 123 (GPR123) in humans. This protein is a member of the adhesion-GPCR family of receptors. Family members are normally characterized by an extended extracellular region with a variable number of protein domains coupled to a TM7 domain via a domain known as the GPCR-Autoproteolysis INducing domain.