ADCY7
ADCY7，即腺苷酸環(huán)化酶7，別名AC7。ADCY7由人類ADCY7基因編碼，該基因位于16號(hào)染色體的q12.1區(qū)域。ADCY7是一種膜結(jié)合的腺苷酸環(huán)化酶，催化ATP形成環(huán)狀A(yù)MP，并可被鈣抑制。ADCY7是腺苷酸環(huán)化酶4類/鳥(niǎo)苷酸環(huán)化酶家族的成員，其特征在于其序列中存在十二個(gè)跨膜結(jié)構(gòu)域。ADCY7在細(xì)胞信號(hào)傳導(dǎo)中起著重要作用，特別是在cAMP生物合成、腺苷酸環(huán)化酶激活以及細(xì)胞內(nèi)信號(hào)轉(zhuǎn)導(dǎo)級(jí)聯(lián)中。異常的ADCY7表達(dá)與多種疾病相關(guān)，包括急性髓系白血?。ˋML），其表達(dá)水平與AML患者的總體生存率呈負(fù)相關(guān)，ADCY7通過(guò)抑制凋亡支持AML細(xì)胞的生長(zhǎng)，并可能通過(guò)影響c-Myc表達(dá)參與白血病的發(fā)展。
熱銷產(chǎn)品
驗(yàn)證數(shù)據(jù)
The image on the left is immunohistochemistry of paraffin-embedded Human breast cancer tissue using CSB-PA898784(ADCY7 Antibody) at dilution 1/60, on the right is treated with synthetic peptide. (Original magnification: ×200)
ADCY7 Antibodies
ADCY7 for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 種屬反應(yīng)性 | 應(yīng)用類型 |
|---|---|---|---|
| CSB-PA006812 | ADCY7 Antibody | Human,Mouse | IHC, IF, ELISA |
| CSB-PA898784 | ADCY7 Antibody | Human | ELISA,IHC |
ADCY7 Proteins
ADCY7 Proteins for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來(lái)源 |
|---|---|---|
| CSB-YP001343HU CSB-EP001343HU CSB-BP001343HU CSB-MP001343HU CSB-EP001343HU-B |
Recombinant Human Adenylate cyclase type 7 (ADCY7), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
ADCY7 Proteins for Mus musculus (Mouse)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來(lái)源 |
|---|---|---|
| CSB-YP001343MO CSB-EP001343MO CSB-BP001343MO CSB-MP001343MO CSB-EP001343MO-B |
Recombinant Mouse Adenylate cyclase type 7 (Adcy7), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
ADCY7 Proteins for Bos taurus (Bovine)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來(lái)源 |
|---|---|---|
| CSB-YP641835BO CSB-EP641835BO CSB-BP641835BO CSB-MP641835BO CSB-EP641835BO-B |
Recombinant Bovine Adenylate cyclase type 7 (ADCY7), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
