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ADAM10

ADAM10全稱(chēng)為解整合素-金屬蛋白酶10,屬于跨膜蛋白家族成員,在細(xì)胞膜表面發(fā)揮關(guān)鍵切割酶功能。ADAM10通過(guò)裂解Notch、E-鈣黏蛋白等重要膜蛋白,調(diào)控細(xì)胞分化與黏附過(guò)程,其異?;罨瘯?huì)破壞細(xì)胞間通訊穩(wěn)態(tài)。在阿爾茨海默病中,ADAM10過(guò)度切割淀粉樣前體蛋白導(dǎo)致β淀粉樣斑塊沉積,已成為該病治療的重要靶點(diǎn)。腫瘤領(lǐng)域研究發(fā)現(xiàn),該蛋白通過(guò)釋放表皮生長(zhǎng)因子受體配體促進(jìn)癌細(xì)胞侵襲轉(zhuǎn)移,在乳腺癌、結(jié)腸癌等惡性腫瘤中呈現(xiàn)高表達(dá)特征。針對(duì)ADAM10的小分子抑制劑(如GI254023X)和單克隆抗體(如LY503307)已進(jìn)入臨床前研究階段,其中部分藥物在動(dòng)物模型中顯示出抑制腫瘤生長(zhǎng)和延緩認(rèn)知衰退的效果,但需解決選擇性差和血腦屏障穿透難題。ADAM10在免疫調(diào)節(jié)和神經(jīng)發(fā)育中的雙重作用使其藥物開(kāi)發(fā)面臨復(fù)雜挑戰(zhàn)。

熱銷(xiāo)產(chǎn)品

ADAM10 Recombinant Monoclonal Antibody (CSB-RA001273MA1HU)

驗(yàn)證數(shù)據(jù)

CSB-RA001273MA1HU

Overlay Peak curve showing Hela cells stained with CSB-RA001273MA1HU (red line) at 1:400. The cells were fixed in 4% formaldehyde (15min) and permeated by 0.2% TritonX-100 for 10min. Then 10% normal goat serum was Incubated to block non-specific protein-protein interactions followed by the antibody (1μg/1*106cells) for 45 min at 4°C. The secondary antibody used was FITC-conjugated Goat Anti-Mouse IgG(H+L) at 1/200 dilution for 35 min at 4°C. Isotype control antibody (green line) was mouse IgG1 (1μg/1*106cells) used under the same conditions. Acquisition of >10, 000 events was performed.

ADAM10 Antibody (CSB-PA001273LA01HU)

驗(yàn)證數(shù)據(jù)

CSB-PA001273LA01HU

Immunofluorescence staining of Hela cells with CSB-PA001273LA01HU at 1:133, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).

CSB-PA001273LA01HU

Immunohistochemistry of paraffin-embedded human colon cancer using CSB-PA001273LA01HU at dilution of 1:100

CSB-PA001273LA01HU

Immunohistochemistry of paraffin-embedded human thymus tissue using CSB-PA001273LA01HU at dilution of 1:100

ADAM10 Antibodies

ADAM10 for Homo sapiens (Human)

ADAM10 Proteins

ADAM10 Proteins for Homo sapiens (Human)

ADAM10 ELISA Kit

ADAM10 ELISA Kit for Homo sapiens (Human)



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