ACVR1
ACVR1，全稱為激活素A受體I型（Activin A receptor type I），也被稱為ALK-2。該蛋白主要參與骨骼、心臟、軟骨、神經(jīng)和生殖系統(tǒng)的發(fā)育和調(diào)節(jié)。ACVR1蛋白與骨形態(tài)發(fā)生蛋白（BMP）信號(hào)通路密切相關(guān)，在疾病與健康中發(fā)揮著重要作用。例如，ACVR1基因突變會(huì)導(dǎo)致進(jìn)行性骨化性纖維發(fā)育不良（FOP），這是一種罕見(jiàn)的常染色體顯性遺傳病，主要特征為先天性雙側(cè)拇指畸形和全身軟組織的進(jìn)行性異位骨化。此外，ACVR1蛋白還在淋巴瘤的發(fā)生發(fā)展中發(fā)揮作用，研究表明PRC2抑制劑通過(guò)激活BMP-ACVR1信號(hào)通路抑制B細(xì)胞淋巴瘤生長(zhǎng)。目前，針對(duì)ACVR1蛋白的藥物研發(fā)主要集中在FOP和淋巴瘤的治療上，例如ACVR1/ALK2和JAK1/2抑制劑莫洛替尼為原發(fā)性骨髓纖維化癥（PMF）帶來(lái)了顯著療效突破，而PRC2抑制劑則有望成為治療B細(xì)胞淋巴瘤的新選擇。
熱銷產(chǎn)品
ACVR1 Antibody (CSB-PA001257ESR2HU)
驗(yàn)證數(shù)據(jù)
Western blot
All lanes: ACVR1 antibody at 6μg/ml
Lane 1: A549 whole cell lysate
Lane 2: HepG2 whole cell lysate
Lane 3: Mouse gonad tissue
Secondary
Goat polyclonal to rabbit IgG at 1/10000 dilution
Predicted band size: 39 kDa
Observed band size: 39 kDa
Immunohistochemistry of paraffin-embedded human kidney tissue using CSB-PA001257ESR2HU at dilution of 1:100
Immunofluorescent analysis of PC-3 cells using CSB-PA001257ESR2HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
ACVR1 Antibodies
ACVR1 for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 種屬反應(yīng)性 | 應(yīng)用類型 |
|---|---|---|---|
| CSB-PA001257ESR2HU | ACVR1 Antibody | Human, Mouse | ELISA, WB, IHC, IF |
| CSB-PA281732 | ACVR1 Antibody | Human,Mouse,Rat | ELISA,IHC |
ACVR1 Proteins
ACVR1 Proteins for Rattus norvegicus (Rat)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來(lái)源 |
|---|---|---|
| CSB-YP001257RA1 CSB-EP001257RA1 CSB-BP001257RA1 CSB-MP001257RA1 CSB-EP001257RA1-B |
Recombinant Rat Activin receptor type-1 (Acvr1), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-CF001257RA | Recombinant Rat Activin receptor type-1 (Acvr1) | in vitro E.coli expression system |
ACVR1 Proteins for Mus musculus (Mouse)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來(lái)源 |
|---|---|---|
| CSB-YP001257MO1 CSB-EP001257MO1 CSB-BP001257MO1 CSB-MP001257MO1 CSB-EP001257MO1-B |
Recombinant Mouse Activin receptor type-1 (Acvr1), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-CF001257MO | Recombinant Mouse Activin receptor type-1 (Acvr1) | in vitro E.coli expression system |
ACVR1 Proteins for Bos taurus (Bovine)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來(lái)源 |
|---|---|---|
| CSB-YP638914BO CSB-EP638914BO CSB-BP638914BO CSB-MP638914BO CSB-EP638914BO-B |
Recombinant Bovine Activin receptor type-1 (ACVR1), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
ACVR1 Proteins for Gallus gallus (Chicken)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來(lái)源 |
|---|---|---|
| CSB-YP856215CH CSB-EP856215CH CSB-BP856215CH CSB-MP856215CH CSB-EP856215CH-B |
Recombinant Chicken Activin receptor type-1 (ACVR1), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
