ACACA

ACACA，全稱為乙酰輔酶A羧化酶α（ACCα），是脂肪酸合成中的關鍵酶，負責催化乙酰輔酶A轉化為丙二酰輔酶A，這一步驟是脂肪酸合成的限速步驟。ACCα在脂肪生成組織中高度表達，參與調控細胞內脂質代謝的平衡。該蛋白還與能量代謝密切相關，通過調節(jié)丙二酰輔酶A的濃度影響線粒體脂肪酸氧化。ACCα的活性受胰島素等激素調節(jié)，其在能量過剩時活性升高，促進脂肪酸儲存；能量不足時活性被抑制，促進脂肪酸分解供能。研究表明，ACACA基因的異常表達或突變與肥胖、2型糖尿病等多種代謝性疾病相關。此外，ACCα在多種腫瘤中表達上調，為癌細胞提供大量脂質以支持快速增殖，并可能通過調節(jié)腫瘤微環(huán)境中的代謝重編程，促進腫瘤侵襲和轉移。目前，針對ACCα的小分子抑制劑已進入臨床試驗，用于治療非酒精性脂肪肝和代謝綜合征，顯示出改善代謝異常的潛力。

熱銷產品

Recombinant Human Acetyl-CoA carboxylase 1 (ACACA), partial (CSB-EP619749HU1)

驗證數(shù)據(jù)

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

ACACA Antibody (CSB-PA934074)

驗證數(shù)據(jù)

Western blot analysis of extracts from 293 and Hela cells using Acetyl CoA Carboxylase Antibody.

ACACA Recombinant Monoclonal Antibody (CSB-RA987620A0HU)

驗證數(shù)據(jù)

Flow cytometric analysis of Phospho-ACC(S79) expression in C2C12 cells using Phospho-ACC(S79) antibody (1635, 1:2,000). Green, isotype control; red, Phospho-ACC(S79).

Immunocytochemical staining of C2C12 cells with Phospho-ACC(S79) antibody. Nuclei were stained blue with DAPI; Phospho-ACC(S79) was stained magenta with Alexa Fluor? 647. Images were taken using Leica stellaris 5. Protein abundance based on laser Intensity and smart gain: Medium. Scale bar: 20 μm.

Western blotting analysis using Phospho-ACC(S79) antibody. Total cell lysates (30 μg) from various cell lines were loaded and separated by SDS-PAGE. The blot was incubated with Phospho-ACC(S79) antibody and HRP-conjugated goat anti-rabbit secondary antibody respectively.

ACACA Antibody

ACACA Protein

ACACA ELISA Kit

ACACA Antibodies

ACACA for Homo sapiens (Human)

產品貨號	產品名稱	種屬反應性	應用類型
CSB-PA934074	ACACA Antibody	Human	ELISA,WB
CSB-PA436513	ACACA (Ab-79) Antibody	Human	ELISA,WB
CSB-PA937691	Phospho-ACACA (Ser79) Antibody	Human	ELISA, WB
CSB-PA000684	Phospho-ACACA (S80) Antibody	Human,Mouse,Rat	WB, IHC, ELISA
CSB-PA000799	ACACA Antibody	Human,Mouse,Rat	WB, IHC, ELISA
CSB-PA009195	Phospho-ACACA (S80) Antibody	Human,Mouse,Rat	WB, IHC, ELISA
CSB-RA903884A0HU	ACACA Recombinant Monoclonal Antibody	Human	ELISA, FC
CSB-RA987620A0HU	ACACA Recombinant Monoclonal Antibody	Human, Mouse, Rat	ELISA, WB, FC, ICC
CSB-RA968137A0HU	ACACA Recombinant Monoclonal Antibody	Human, Mouse, Rat	ELISA, WB, FC

ACACA Proteins

ACACA Proteins for Rattus norvegicus (Rat)

產品貨號	產品名稱	來源
CSB-YP001119RA	Recombinant Rat Acetyl-CoA carboxylase 1 (Acaca), partial	Yeast
CSB-EP001119RA	Recombinant Rat Acetyl-CoA carboxylase 1 (Acaca), partial	E.coli
CSB-BP001119RA CSB-MP001119RA CSB-EP001119RA-B	Recombinant Rat Acetyl-CoA carboxylase 1 (Acaca), partial	Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

ACACA Proteins for Homo sapiens (Human)

產品貨號	產品名稱	來源
CSB-YP619749HU CSB-EP619749HU CSB-BP619749HU CSB-MP619749HU CSB-EP619749HU-B	Recombinant Human Acetyl-CoA carboxylase 1 (ACACA), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli
CSB-EP619749HU1	Recombinant Human Acetyl-CoA carboxylase 1 (ACACA), partial	E.coli

ACACA Proteins for Ovis aries (Sheep)

產品貨號	產品名稱	來源
CSB-YP637908SH CSB-EP637908SH CSB-BP637908SH CSB-MP637908SH CSB-EP637908SH-B	Recombinant Sheep Acetyl-CoA carboxylase 1 (ACACA), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

ACACA Proteins for Mus musculus (Mouse)

產品貨號	產品名稱	來源
CSB-YP729191MO CSB-EP729191MO CSB-BP729191MO CSB-MP729191MO CSB-EP729191MO-B	Recombinant Mouse Acetyl-CoA carboxylase 1 (Acaca), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

ACACA Proteins for Bos taurus (Bovine)

產品貨號	產品名稱	來源
CSB-YP883294BO CSB-EP883294BO CSB-BP883294BO CSB-MP883294BO CSB-EP883294BO-B	Recombinant Bovine Acetyl-CoA carboxylase 1 (ACACA), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli