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ABL1

ABL1,別名c-Abl、p150、BCR-ABL1等。它是一種由ABL1基因編碼的非受體酪氨酸激酶,主要在各種細(xì)胞中表達(dá),包括造血細(xì)胞。ABL1的作用機(jī)制涉及多種生物學(xué)過(guò)程,包括細(xì)胞信號(hào)傳導(dǎo)、細(xì)胞周期控制、細(xì)胞分化和凋亡。在細(xì)胞中,ABL1通過(guò)磷酸化多種底物蛋白來(lái)調(diào)控信號(hào)轉(zhuǎn)導(dǎo)途徑,影響細(xì)胞的生長(zhǎng)、運(yùn)動(dòng)和存活。ABL1的異常激活與多種癌癥的發(fā)生發(fā)展相關(guān),尤其是與費(fèi)城染色體陽(yáng)性的慢性髓性白血病(CML)有關(guān),這是由于ABL1基因與BCR基因的融合導(dǎo)致的。這種融合蛋白具有持續(xù)的酪氨酸激酶活性,導(dǎo)致細(xì)胞失控增殖。ABL1也是多種癌癥治療藥物的靶點(diǎn),如伊馬替尼(Imatinib),它通過(guò)抑制ABL1的激酶活性來(lái)治療CML和其他ABL1相關(guān)的癌癥。

熱銷產(chǎn)品

Recombinant Human Tyrosine-protein kinase ABL1 (ABL1), partial (CSB-RP043554h)

驗(yàn)證數(shù)據(jù)

CSB-RP043554h

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

ABL1 Antibody (CSB-PA04355A0Rb)

驗(yàn)證數(shù)據(jù)

CSB-PA04355A0Rb

IHC image of CSB-PA04355A0Rb diluted at 1:1200 and staining in paraffin-embedded human colon cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.

CSB-PA04355A0Rb

Immunoprecipitating ABL1 in Hela whole cell lysate
Lane 1: Rabbit control IgG (1µg) instead of CSB-PA04355A0Rb in Hela whole cell lysate. For western blotting, a HRP-conjugated Protein G antibody was used as the secondary antibody (1/2000)
Lane 2: CSB-PA04355A0Rb (6µg) + Hela whole cell lysate (500µg)
Lane 3: Hela whole cell lysate (10µg)

Human Tyrosine-protein kinase ABL1(ABL1) ELISA kit (CSB-EL001105HU)

驗(yàn)證數(shù)據(jù)

CSB-EL001105HU 標(biāo)準(zhǔn)曲線

貨號(hào):CSB-EL001105HU

規(guī)格:96T/48T

靈敏度:6.25 pg/mL

檢測(cè)范圍:25 pg/mL-1600 pg/mL

These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.

ABL1 Antibodies

ABL1 for Homo sapiens (Human)

ABL1 Proteins

ABL1 Proteins for Homo sapiens (Human)

ABL1 Proteins for Mus musculus (Mouse)

ABL1 ELISA Kit

ABL1 ELISA Kit for Homo sapiens (Human)



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