UNC13A
UNC13A，即unc-13同源物A，別名Munc13-1。它是一種由人類基因編碼的蛋白質(zhì)，屬于UNC13家族。UNC13A在突觸小體中分布，具有活性，能夠結(jié)合鋅離子、二酰甘油和金屬離子。UNC13A的作用機制涉及與佛波醇酯和甘油二酯結(jié)合，在突觸神經(jīng)遞質(zhì)釋放中發(fā)揮重要作用。該基因的單核苷酸多態(tài)性可能與散發(fā)性肌萎縮側(cè)索硬化（ALS）有關(guān)。UNC13A在神經(jīng)元組織中表達，參與維持突觸活性區(qū)域，通過使突觸囊泡的啟動和對接來發(fā)揮作用。在沒有功能性TDP-43的情況下，UNC13A的風(fēng)險變異會導(dǎo)致UNC13A信使RNA中包含一個隱蔽的外顯子，隨后導(dǎo)致無意義介導(dǎo)的衰變，從而失去功能性蛋白。UNC13A的耗竭會導(dǎo)致神經(jīng)傳導(dǎo)障礙。UNC13A不僅在神經(jīng)生物學(xué)中具有重要作用，而且在ALS的治療發(fā)展中被視為一個潛在的治療靶點。
熱銷產(chǎn)品
Recombinant Human Protein unc-13 homolog A (UNC13A), partial (CSB-MP891983HU)
驗證數(shù)據(jù)
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
UNC13A Antibodies
UNC13A for Homo sapiens (Human)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 種屬反應(yīng)性 | 應(yīng)用類型 |
|---|---|---|---|
| CSB-PA025621GA01HU | UNC13A Antibody | Human,Mouse,Rat | ELISA,WB |
UNC13A Proteins
UNC13A Proteins for Mus musculus (Mouse)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP680183MO CSB-EP680183MO CSB-BP680183MO CSB-EP680183MO-B |
Recombinant Mouse Protein unc-13 homolog A (Unc13a), partial | Yeast E.coli Baculovirus In Vivo Biotinylation in E.coli |
UNC13A Proteins for Rattus norvegicus (Rat)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP723474RA CSB-EP723474RA CSB-BP723474RA CSB-MP723474RA CSB-EP723474RA-B |
Recombinant Rat Protein unc-13 homolog A (Unc13a), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
UNC13A Proteins for Homo sapiens (Human)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP891983HU CSB-BP891983HU CSB-EP891983HU-B |
Recombinant Human Protein unc-13 homolog A (UNC13A), partial | Yeast Baculovirus In Vivo Biotinylation in E.coli |
| CSB-EP891983HU | Recombinant Human Protein unc-13 homolog A (UNC13A), partial | E.coli |
| CSB-MP891983HU | Recombinant Human Protein unc-13 homolog A (UNC13A), partial | Mammalian cell |
