IFNGR1
IFNGR1，全稱為干擾素γ受體1，常用別名包括CD119。它是存在于細胞膜表面的受體分子，可與干擾素γ特異性結(jié)合，參與調(diào)控機體免疫應(yīng)答：通過這一結(jié)合，能推動免疫細胞的活化與功能發(fā)揮，助力清除病原體如分枝桿菌、病毒等。
IFNGR1功能異常，機體對特定病原體的抵抗力會降低，比如引發(fā)常染色體隱性遺傳的免疫缺陷病，患者易反復出現(xiàn)嚴重分枝桿菌感染或機會性感染。此外，其表達或活性異常也可能與自身免疫病、腫瘤相關(guān)——部分自身免疫病中，它的信號紊亂可能加重免疫細胞對自身組織的損傷；某些腫瘤里，它的異常可能影響免疫細胞對腫瘤細胞的識別與清除。目前針對該蛋白的藥物研發(fā)集中在免疫調(diào)節(jié)方向，一些候選藥物嘗試通過調(diào)控其活性治療感染性疾病或自身免疫病，部分已進入臨床前或早期臨床研究階段，期望調(diào)整免疫平衡改善疾病狀態(tài)。
熱銷產(chǎn)品
Recombinant Human Interferon gamma receptor 1 (IFNGR1), partial (CSB-MP011051HU1d7)
驗證數(shù)據(jù)
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
IFNGR1 Recombinant Monoclonal Antibody (CSB-RA234462A0HU)
驗證數(shù)據(jù)
Flow cytometric analysis of Interferon gamma receptor 1 expression in C2C12 cells using Interferon gamma receptor 1 antibody. Green, isotype control; red, Interferon gamma receptor 1.
Immunocytochemical staining of C2C12 cells with Interferon gamma receptor 1 antibody. Nuclei were stained blue with DAPI; Interferon gamma receptor 1 was stained magenta with Alexa Fluor? 647. Images were taken using Leica stellaris 5. Protein abundance based on laser Intensity and smart gain: Medium. Scale bar, 20 μm.
Western blotting analysis using interferon gamma receptor 1 antibody. Total cell lysates (30 μg) from various cell lines were loaded and separated by SDS-PAGE. The blot was incubated with interferon gamma receptor 1 antibody and HRP-conjugated goat anti-mouse secondary antibody respectively.
IFNGR1 Antibody (CSB-PA011051DSR2HU)
驗證數(shù)據(jù)
Western blot
All lanes: IFNGR1 antibody at 2μg/ml + Mouse lung tissue
Secondary
Goat polyclonal to rabbit IgG at 1/10000 dilution
Predicted band size: 55, 22 kDa
Observed band size: 55 kDa
IFNGR1 Antibodies
IFNGR1 for Homo sapiens (Human)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 種屬反應(yīng)性 | 應(yīng)用類型 |
|---|---|---|---|
| CSB-PA011051GA01HU | IFNGR1 Antibody | Human | ELISA,WB,IHC |
| CSB-PA011051DSR2HU | IFNGR1 Antibody | Human | ELISA, WB |
| CSB-PA005631 | IFNGR1 Antibody | Human | WB, ELISA |
| CSB-PA009475 | Phospho-IFNGR1 (Y457) Antibody | Human,Mouse,Rat,Monkey | WB, IHC, IF, ELISA |
| CSB-PA009477 | IFNGR1 Antibody | Human,Mouse,Rat,Monkey | WB, IHC, IF, ELISA |
| CSB-RA039517A0HU | IFNGR1 Recombinant Monoclonal Antibody | Human | ELISA, IHC, IF |
| CSB-RA234462A0HU | IFNGR1 Recombinant Monoclonal Antibody | Human, Mouse, Rat | ELISA, WB, FC, ICC |
IFNGR1 Proteins
IFNGR1 Proteins for Mus musculus (Mouse)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP011051MO1 CSB-EP011051MO1 CSB-BP011051MO1 CSB-MP011051MO1 CSB-EP011051MO1-B |
Recombinant Mouse Interferon gamma receptor 1 (Ifngr1), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-CF011051MO | Recombinant Mouse Interferon gamma receptor 1 (Ifngr1) | in vitro E.coli expression system |
IFNGR1 Proteins for Homo sapiens (Human)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP011051HU1 CSB-EP011051HU1 CSB-BP011051HU1 CSB-EP011051HU1-B |
Recombinant Human Interferon gamma receptor 1 (IFNGR1), partial | Yeast E.coli Baculovirus In Vivo Biotinylation in E.coli |
| CSB-CF011051HU | Recombinant Human Interferon gamma receptor 1 (IFNGR1) | in vitro E.coli expression system |
| CSB-MP011051HU1 | Recombinant Human Interferon gamma receptor 1 (IFNGR1), partial | Mammalian cell |
| CSB-MP011051HU1d9 | Recombinant Human Interferon gamma receptor 1 (IFNGR1), partial | Mammalian cell |
| CSB-MP011051HU1d7 | Recombinant Human Interferon gamma receptor 1 (IFNGR1), partial | Mammalian cell |
