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  4. ZG16B (Ulenistamab Biosimilar) Recombinant Monoclonal Antibody

ZG16B (Ulenistamab Biosimilar) Recombinant Monoclonal Antibody

  • 貨號：
    CSB-RA836195MB2HU
  • 規(guī)格：
    ￥83486
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品描述：
    ZG16B(Ulenistamab Biosimilar Antibody)重組單克隆抗體是一款專為科研用途開發(fā)的生物制劑，其核心成分為通過基因工程技術(shù)制備的單克隆抗體。該產(chǎn)品采用重組DNA技術(shù)在合適的表達(dá)系統(tǒng)中進(jìn)行生產(chǎn)，確保了批間一致性和高純度，為科研實驗提供可靠的物質(zhì)基礎(chǔ)。 在分子結(jié)構(gòu)設(shè)計上，ZG16B重組單克隆抗體具有高度特異性的抗原結(jié)合位點，能夠精準(zhǔn)識別并結(jié)合靶標(biāo)分子，這一特性使其在蛋白質(zhì)相互作用研究、信號通路分析以及生物標(biāo)志物檢測等科研場景中具有重要應(yīng)用價值。其抗體分子的恒定區(qū)和可變區(qū)經(jīng)過優(yōu)化設(shè)計，既保留了與Fc受體的結(jié)合能力，又增強(qiáng)了對抗原的親和力，可滿足多種實驗需求。 作為科研工具，ZG16B重組單克隆抗體適用于多種實驗技術(shù)。在細(xì)胞生物學(xué)研究中，可用于分析靶蛋白的表達(dá)水平、亞細(xì)胞定位及動態(tài)變化；在分子免疫學(xué)領(lǐng)域，有助于探究免疫調(diào)節(jié)機(jī)制及相關(guān)疾病的病理過程。該產(chǎn)品僅用于實驗室研究，不可用于臨床診斷或治療用途。 ZG16B重組單克隆抗體的生產(chǎn)過程嚴(yán)格遵循科研試劑的質(zhì)量控制標(biāo)準(zhǔn)，通過多步純化工藝去除雜質(zhì)，并經(jīng)過嚴(yán)格的活性檢測和無菌性驗證，確保產(chǎn)品在科研實驗中的穩(wěn)定性和可靠性。其儲存和使用需按照說明書要求進(jìn)行，以保持抗體的生物學(xué)活性，為科研人員提供高質(zhì)量的實驗材料支持。
  • Uniprot No.：
  • 基因名：
  • 別名：
    Anti-(pancreatic adenocarcinoma upregulated factor) IgG1 humanised monoclonal antibody research-grade biosimilar; Anti-PAUF antibody research-grade biosimilar; PBP 1510 research-grade biosimilar; PBP-1510 research-grade biosimilar ;ZG16B antibody; PAUF antibody; UNQ773/PRO1567 antibody; Pancreatic adenocarcinoma up-regulated factor antibody; Zymogen granule protein 16 homolog B antibody
  • 反應(yīng)種屬：
    Human
  • 免疫原：
    Recombinant Human ZG16B protein
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標(biāo)記方式：
    Non-conjugated
  • 克隆類型：
    Monoclonal
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    0.01M PBS，pH7.4
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用說明：
    Validation Status
    Application-specific performance (e.g., in flow cytometry, ELISA, IHC or other assay formats) has not yet been experimentally verified by CUSABIO. Users are advised to determine the optimal working conditions empirically in their own assay systems.
    Guaranteed Quality
    ① Antibody purity?> 95% tested by SDS-PAGE.
    ② Endotoxin level < 0.1EU/ug tested by LAL method.
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    3-4 weeks
  • 用途：
    It is a non-therapeutic biosimilar antibody, owning the same variable region from the corresponding approved therapeutic antibody. In conclusion, it is a research-grade biosimilar antibody and expressed in mammalian cell, which can be directly used as positive controls in drug discovery or used for rapid verification of the biological functions of target protein.

產(chǎn)品評價

靶點詳情

  • 基因功能參考文獻(xiàn)：
    1. we conclude that the PAUF is a powerful and multifunctional promoter of tumor growth through increase and functional activation of myeloid-derived suppressor cells PMID: 27322081
    2. Mouse DCPP1 is a multifunctional promoter of tumor growth through functional activation of pancreatic cancer cells, suggesting it to be an ortholog of human PAUF. PMID: 28988106
    3. Our results suggest that PAUF has tumour-promoting functions in oral squamous cell carcinoma PMID: 27706833
    4. High PAUF expression is associated with resistance to gemcitabine in pancreatic cancer. PMID: 26684804
    5. PAUF mediated dendritic cell activation and immune stimulation are dependent on TLR4 PMID: 26336989
    6. constitutive suppression of PAUF sensitized Bxpc3 pancreatic cancer cells to oncolytic parvovirus H-1 infection PMID: 25727013
    7. PAUF rs12373A>C polymorphisms are associated with colorectal cancer. PMID: 25079514
    8. PAUF-siRNA inhibited the proliferation of colorectal cancer cells, promoted their apoptosis and induced G0/G1 cell cycle arrest. At the same time, PAUF-siRNA inhibited the invasion, adhesion and migration of the tumor cells. PMID: 23677445
    9. new possibilities for PAUF's role in the pathogenesis of angiogenesis-dependent diseases PMID: 22907431
    10. activation of SIRT1 inhibited the proliferation of pancreatic cancer -PAUF cells by down-regulation of cyclin-D1, a target molecule of beta-catenin. PMID: 22640743
    11. PAUF-mediated FAK activation plays an important role in pancreatic cancer progression. PMID: 21464589
    12. PAUF can up-regulate and stabilize beta-catenin via a novel pattern of phosphorylation, thereby contributing to the rapid proliferation of pancreatic cancer cells. PMID: 21196815
    13. Data demonstrate that the host salivary protein CSP-1 (HRPE773 GenBank AAQ89380.1) binds to S. mutans cells and may influence the initial colonization of this pathogenic bacterium onto the tooth surface. PMID: 20858015
    14. the sugar-binding site and the adjacent basic patch of ZG16p and ZG16b cooperatively form a functional glycosaminoglycan-binding site. PMID: 21110947
    15. PAUF is a mammalian lectin normally found in plant lectins. PAUF induces extracellular signal-regulated kinase phosphorylation and activates the IKK-b-mediated TPL2/MEK/ERK signaling pathway through TLR2. PMID: 20802527
    16. Findings indicate that PAUF enhances the metastatic potential of pancreatic cancer cells, at least in part, by upregulating CXCR4 expression. PMID: 19784070
    17. Bioinformatic analysis identified a putative human CSP-1/Dcpp ortholog, HRPE773, expressed predominantly in human salivary tissue, that shows 31% amino acid identity and 45% amino acid similarity to the mouse Dcpp query sequence. PMID: 16954406
    18. pancreatic adenocarcinoma up-regulated factor was secreted into the culture medium of pancreatic adenocarcinoma up-regulated factor-overexpressing Chinese hamster ovary cells, had an apparent molecular mass of approximately 25 kDa, and was N-glycosylated PMID: 19302292

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  • 亞細(xì)胞定位：
    Secreted.
  • 蛋白家族：
    Jacalin lectin family
  • 數(shù)據(jù)庫鏈接：

    HGNC: 30456

    KEGG: hsa:124220

    STRING: 9606.ENSP00000371715

    UniGene: Hs.105887



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