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  4. ZG16B (US20200055951A1 Biosimilar) Recombinant Monoclonal Antibody

ZG16B (US20200055951A1 Biosimilar) Recombinant Monoclonal Antibody

  • 貨號(hào)：
    CSB-RA836195MB1HU
  • 規(guī)格：
    ￥83486
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品描述：
    ZG16B（US20200055951A1 Biosimilar Antibody）重組單克隆抗體是一種針對(duì)人源ZG16B蛋白，其別名為ZG16B、Zymogen granule protein 16 homolog B或UNQ773/PRO1567。該抗體以重組人ZG16B蛋白制備，具有明確的抗原特異性，可特異性識(shí)別ZG16B蛋白。其種屬反應(yīng)性經(jīng)驗(yàn)證可覆蓋人類(lèi)和食蟹猴（Macaca fascicularis），為跨物種研究提供了可靠工具。 ZG16B作為藥物其，其研發(fā)旨在為相關(guān)疾病治療提供更多選擇。由于ZG16B蛋白可能參與多種生理和病理過(guò)程，針對(duì)該靶點(diǎn)類(lèi)似物有望用于探索其在消化系統(tǒng)疾病、免疫調(diào)節(jié)紊亂等疾病中的治療作用，為開(kāi)發(fā)新的診斷標(biāo)志物或治療手段奠定基礎(chǔ)。目前，以ZG16B為靶點(diǎn)類(lèi)似物臨床前研究正逐步推進(jìn)，重點(diǎn)關(guān)注其安全性、有效性及藥代動(dòng)力學(xué)特性。 ZG16B重組單克隆抗體憑借高特異性和種屬交叉反應(yīng)性，成為生命科學(xué)研究的重要工具。研究人員可利用該抗體進(jìn)行ZG16B蛋白的表達(dá)定位、定量分析及相互作用研究，深入探究其在細(xì)胞信號(hào)傳導(dǎo)、組織發(fā)育等生物學(xué)過(guò)程中的功能。在食蟹猴模型中，該抗體可用于臨床前藥效學(xué)和毒理學(xué)評(píng)價(jià)，加速?gòu)幕A(chǔ)研究到臨床應(yīng)用的轉(zhuǎn)化進(jìn)程，為揭示疾病發(fā)病機(jī)制和開(kāi)發(fā)創(chuàng)新療法提供有力支持。
  • Uniprot No.：
  • 基因名：
  • 別名：
    ZG16B; Zymogen granule protein 16 homolog B; UNQ773/PRO1567
  • 反應(yīng)種屬：
    Human
  • 免疫原：
    Recombinant Human ZG16B protein
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標(biāo)記方式：
    Non-conjugated
  • 克隆類(lèi)型：
    Monoclonal
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    0.01M PBS，pH7.4
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用說(shuō)明：
    Validation Status
    Application-specific performance (e.g., in flow cytometry, ELISA, IHC or other assay formats) has not yet been experimentally verified by CUSABIO. Users are advised to determine the optimal working conditions empirically in their own assay systems.
    Guaranteed Quality
    ① Antibody purity?> 95% tested by SDS-PAGE.
    ② Endotoxin level < 0.1EU/ug tested by LAL method.
  • 儲(chǔ)存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    In stock
  • 用途：
    It is a non-therapeutic biosimilar antibody, owning the same variable region from the corresponding approved therapeutic antibody. In conclusion, it is a research-grade biosimilar antibody and expressed in mammalian cell, which can be directly used as positive controls in drug discovery or used for rapid verification of the biological functions of target protein.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 基因功能參考文獻(xiàn)：
    1. we conclude that the PAUF is a powerful and multifunctional promoter of tumor growth through increase and functional activation of myeloid-derived suppressor cells PMID: 27322081
    2. Mouse DCPP1 is a multifunctional promoter of tumor growth through functional activation of pancreatic cancer cells, suggesting it to be an ortholog of human PAUF. PMID: 28988106
    3. Our results suggest that PAUF has tumour-promoting functions in oral squamous cell carcinoma PMID: 27706833
    4. High PAUF expression is associated with resistance to gemcitabine in pancreatic cancer. PMID: 26684804
    5. PAUF mediated dendritic cell activation and immune stimulation are dependent on TLR4 PMID: 26336989
    6. constitutive suppression of PAUF sensitized Bxpc3 pancreatic cancer cells to oncolytic parvovirus H-1 infection PMID: 25727013
    7. PAUF rs12373A>C polymorphisms are associated with colorectal cancer. PMID: 25079514
    8. PAUF-siRNA inhibited the proliferation of colorectal cancer cells, promoted their apoptosis and induced G0/G1 cell cycle arrest. At the same time, PAUF-siRNA inhibited the invasion, adhesion and migration of the tumor cells. PMID: 23677445
    9. new possibilities for PAUF's role in the pathogenesis of angiogenesis-dependent diseases PMID: 22907431
    10. activation of SIRT1 inhibited the proliferation of pancreatic cancer -PAUF cells by down-regulation of cyclin-D1, a target molecule of beta-catenin. PMID: 22640743
    11. PAUF-mediated FAK activation plays an important role in pancreatic cancer progression. PMID: 21464589
    12. PAUF can up-regulate and stabilize beta-catenin via a novel pattern of phosphorylation, thereby contributing to the rapid proliferation of pancreatic cancer cells. PMID: 21196815
    13. Data demonstrate that the host salivary protein CSP-1 (HRPE773 GenBank AAQ89380.1) binds to S. mutans cells and may influence the initial colonization of this pathogenic bacterium onto the tooth surface. PMID: 20858015
    14. the sugar-binding site and the adjacent basic patch of ZG16p and ZG16b cooperatively form a functional glycosaminoglycan-binding site. PMID: 21110947
    15. PAUF is a mammalian lectin normally found in plant lectins. PAUF induces extracellular signal-regulated kinase phosphorylation and activates the IKK-b-mediated TPL2/MEK/ERK signaling pathway through TLR2. PMID: 20802527
    16. Findings indicate that PAUF enhances the metastatic potential of pancreatic cancer cells, at least in part, by upregulating CXCR4 expression. PMID: 19784070
    17. Bioinformatic analysis identified a putative human CSP-1/Dcpp ortholog, HRPE773, expressed predominantly in human salivary tissue, that shows 31% amino acid identity and 45% amino acid similarity to the mouse Dcpp query sequence. PMID: 16954406
    18. pancreatic adenocarcinoma up-regulated factor was secreted into the culture medium of pancreatic adenocarcinoma up-regulated factor-overexpressing Chinese hamster ovary cells, had an apparent molecular mass of approximately 25 kDa, and was N-glycosylated PMID: 19302292

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  • 亞細(xì)胞定位：
    Secreted.
  • 蛋白家族：
    Jacalin lectin family
  • 數(shù)據(jù)庫(kù)鏈接：

    HGNC: 30456

    KEGG: hsa:124220

    STRING: 9606.ENSP00000371715

    UniGene: Hs.105887



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