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  4. VSIR (Solnerstotug Biosimilar) Recombinant Monoclonal Antibody

VSIR (Solnerstotug Biosimilar) Recombinant Monoclonal Antibody

  • 貨號：
    CSB-RA884484MB4HU
  • 規(guī)格：
    ￥83486
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品描述：
    VSIR (Solnerstotug Biosimilar Antibody)重組單克隆抗體是一種用于科研領(lǐng)域的生物試劑。該產(chǎn)品通過重組DNA技術(shù)制備，具有高特異性和親和力，可精準(zhǔn)識別并結(jié)合目標(biāo)分子，為相關(guān)研究提供可靠工具。 在科研應(yīng)用中，該抗體可廣泛用于蛋白質(zhì)檢測、細(xì)胞分選某些實(shí)驗(yàn)。其高度均一的結(jié)構(gòu)和穩(wěn)定的性能，有助于提高實(shí)驗(yàn)結(jié)果的可重復(fù)性和準(zhǔn)確性。研究人員可利用該抗體深入探究VSIR蛋白在生理和病理過程中的作用機(jī)制，為疾病研究和藥物開發(fā)提供重要支持。 該抗體的生產(chǎn)過程嚴(yán)格遵循質(zhì)量控制標(biāo)準(zhǔn)，確保產(chǎn)品的純度和活性。其特異性結(jié)合能力使其成為研究VSIR相關(guān)信號通路、受體-配體相互作用等領(lǐng)域的理想選擇。通過使用該抗體，科研人員能夠更深入地了解VSIR蛋白的功能，為相關(guān)領(lǐng)域的研究突破奠定基礎(chǔ)。 作為科研用試劑，該產(chǎn)品為生命科學(xué)研究提供了有力的工具，有助于推動免疫學(xué)、細(xì)胞生物學(xué)等學(xué)科的發(fā)展。其可靠的性能和廣泛的適用性，使其成為科研實(shí)驗(yàn)室中不可或缺的實(shí)驗(yàn)材料，支持科研人員在探索生命奧秘的道路上不斷取得新的發(fā)現(xiàn)。
  • Uniprot No.：
  • 基因名：
  • 別名：
    SNS101 research-grade biosimilar; SNS-101 research-grade biosimilar; SNS 101 (Sensei Biotherapeutics) research-grade biosimilar; SNS-101(Sensei Biotherapeutics) research-grade biosimilar; SNS-101 - Sensei Biotherapeutics research-grade biosimilar; SNS-VISTA research-grade biosimilar ;VSIR antibody; C10orf54 antibody; SISP1 antibody; VISTA antibody; PP2135 antibody; UNQ730/PRO1412 antibody; V-type immunoglobulin domain-containing suppressor of T-cell activation antibody; Platelet receptor Gi24 antibody; Stress-induced secreted protein-1 antibody; Sisp-1 antibody; V-set domain-containing immunoregulatory receptor antibody; V-set immunoregulatory receptor antibody
  • 反應(yīng)種屬：
    Human
  • 免疫原：
    Recombinant Human VSIR protein
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標(biāo)記方式：
    Non-conjugated
  • 克隆類型：
    Monoclonal
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    0.01M PBS，pH7.4
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用說明：
    Validation Status
    Application-specific performance (e.g., in flow cytometry, ELISA, IHC or other assay formats) has not yet been experimentally verified by CUSABIO. Users are advised to determine the optimal working conditions empirically in their own assay systems.
    Guaranteed Quality
    ① Antibody purity?> 95% tested by SDS-PAGE.
    ② Endotoxin level < 0.1EU/ug tested by LAL method.
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    3-4 weeks
  • 用途：
    It is a non-therapeutic biosimilar antibody, owning the same variable region from the corresponding approved therapeutic antibody. In conclusion, it is a research-grade biosimilar antibody and expressed in mammalian cell, which can be directly used as positive controls in drug discovery or used for rapid verification of the biological functions of target protein.

產(chǎn)品評價

靶點(diǎn)詳情

  • 功能：
    Immunoregulatory receptor which inhibits the T-cell response. May promote differentiation of embryonic stem cells, by inhibiting BMP4 signaling. May stimulate MMP14-mediated MMP2 activation.
  • 基因功能參考文獻(xiàn)：
    1. Data indicate that VISTA is predominantly expressed and up-regulated in the high-density infiltrated immune cells but minimal in pancreatic cancerous cells. PMID: 29771768
    2. High VISTA expression is associated with colorectal carcinoma. PMID: 30128738
    3. VISTA expression supports immune-complex inflammation in collagen antibody-induced arthritis and VISTA is expressed in human synovium PMID: 29216931
    4. This study is the first to describe the expression of VISTA-expressing lymphocytes in melanoma samples and in the context of acquired resistance to immune checkpoint inhibitors PMID: 28776578
    5. Taken together, the results indicated that the VISTA high and CD8 low group, as an immunosuppressive subgroup, might be associated with a poor prognosis in primary OSCC. These findings indicated that VISTA might be a potential immunotherapeutic target in OSCC treatment. PMID: 28236118
    6. this review describes the functions of VISTA in the context of cancer immunotherapy PMID: 28258694
    7. overexpression of the newly described co-stimulatory molecule, PD1 homologue (PD-1H) in human monocyte/macrophages is sufficient to induce spontaneous secretion of multiple cytokines. PMID: 25279955
    8. p53-induced expression of DD1alpha prevents persistence of cell corpses and ensures efficient generation of precise immune responses in mice. PMID: 26228159
    9. Results suggest that GI24 contributes to tumor-invasive growth in the collagen matrix by augmenting cell surface MT1-MMP. PMID: 20666777

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  • 亞細(xì)胞定位：
    Cell membrane; Single-pass type I membrane protein.
  • 組織特異性：
    Expressed in spleen. Detected on a number of myeloid cells including CD11b monocytes, CD66b+ neutrophils, at low levels on CD4+ and CD8+ T-cells, and in a subset of NK cells. Not detected on B cells (at protein level). Expressed at high levels in placenta
  • 數(shù)據(jù)庫鏈接：

    HGNC: 30085

    OMIM: 615608

    KEGG: hsa:64115

    STRING: 9606.ENSP00000378409

    UniGene: Hs.47382



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