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  4. VSIR (KVA-12.1 Biosimilar) Recombinant Monoclonal Antibody

VSIR (KVA-12.1 Biosimilar) Recombinant Monoclonal Antibody

  • 貨號(hào)：
    CSB-RA884484MB2HU
  • 規(guī)格：
    ￥83486
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品描述：
    VSIR (KVA-12.1 Biosimilar Antibody)重組單克隆抗體是一款針對(duì)VSIR靶點(diǎn)研發(fā)的生物工程抗體產(chǎn)品，專(zhuān)為科研用途設(shè)計(jì)。該抗體通過(guò)重組DNA技術(shù)在哺乳動(dòng)物細(xì)胞表達(dá)系統(tǒng)中制備，具有高純度、高特異性和批次間一致性等特點(diǎn)，為免疫學(xué)、腫瘤學(xué)等領(lǐng)域的基礎(chǔ)研究及藥物開(kāi)發(fā)提供有力工具。 作為靶向VSIR的單克隆抗體，其核心優(yōu)勢(shì)在于能夠特異性識(shí)別并結(jié)合VSIR蛋白，從而深入探究該免疫檢查點(diǎn)分子在免疫調(diào)節(jié)中的作用機(jī)制。VSIR作為近年來(lái)發(fā)現(xiàn)的重要免疫調(diào)節(jié)靶點(diǎn)，在T細(xì)胞活化、免疫耐受維持及腫瘤微環(huán)境調(diào)控中扮演關(guān)鍵角色。通過(guò)使用該抗體，研究人員可在體外細(xì)胞模型及動(dòng)物模型中開(kāi)展VSIR信號(hào)通路解析、受體-配體相互作用分析、免疫細(xì)胞功能調(diào)控某些實(shí)驗(yàn)，為揭示免疫相關(guān)疾病的發(fā)病機(jī)制提供重要實(shí)驗(yàn)依據(jù)。 產(chǎn)品采用嚴(yán)格的生產(chǎn)工藝和質(zhì)量控制標(biāo)準(zhǔn)，確保抗體的生物學(xué)活性和結(jié)構(gòu)完整性。其應(yīng)用場(chǎng)景廣泛，包括但不限于、功能性細(xì)胞實(shí)驗(yàn)等，滿(mǎn)足不同研究方向的技術(shù)需求。此外，該抗體經(jīng)過(guò)優(yōu)化的配方設(shè)計(jì)，可在-20℃條件下長(zhǎng)期穩(wěn)定保存，有效保障實(shí)驗(yàn)結(jié)果的可重復(fù)性與可靠性。 VSIR (KVA-12.1 Biosimilar Antibody)重組單克隆抗體的開(kāi)發(fā)為科研人員提供了高質(zhì)量的研究工具，助力深入探索VSIR靶點(diǎn)的生物學(xué)功能及潛在的臨床應(yīng)用價(jià)值，推動(dòng)相關(guān)領(lǐng)域的科學(xué)研究進(jìn)展。
  • Uniprot No.：
  • 基因名：
  • 別名：
    KVA12.1 research-grade biosimilar; KVA 12.1 research-grade biosimilar; KVA-12.1 research-grade biosimilar; KVA12123 research-grade biosimilar; TBS-2025 research-grade biosimilar ;VSIR antibody; C10orf54 antibody; SISP1 antibody; VISTA antibody; PP2135 antibody; UNQ730/PRO1412 antibody; V-type immunoglobulin domain-containing suppressor of T-cell activation antibody; Platelet receptor Gi24 antibody; Stress-induced secreted protein-1 antibody; Sisp-1 antibody; V-set domain-containing immunoregulatory receptor antibody; V-set immunoregulatory receptor antibody
  • 反應(yīng)種屬：
    Human
  • 免疫原：
    Recombinant Human VSIR protein
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標(biāo)記方式：
    Non-conjugated
  • 克隆類(lèi)型：
    Monoclonal
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    0.01M PBS，pH7.4
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用說(shuō)明：
    Validation Status
    Application-specific performance (e.g., in flow cytometry, ELISA, IHC or other assay formats) has not yet been experimentally verified by CUSABIO. Users are advised to determine the optimal working conditions empirically in their own assay systems.
    Guaranteed Quality
    ① Antibody purity?> 95% tested by SDS-PAGE.
    ② Endotoxin level < 0.1EU/ug tested by LAL method.
  • 儲(chǔ)存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    3-4 weeks
  • 用途：
    It is a non-therapeutic biosimilar antibody, owning the same variable region from the corresponding approved therapeutic antibody. In conclusion, it is a research-grade biosimilar antibody and expressed in mammalian cell, which can be directly used as positive controls in drug discovery or used for rapid verification of the biological functions of target protein.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能：
    Immunoregulatory receptor which inhibits the T-cell response. May promote differentiation of embryonic stem cells, by inhibiting BMP4 signaling. May stimulate MMP14-mediated MMP2 activation.
  • 基因功能參考文獻(xiàn)：
    1. Data indicate that VISTA is predominantly expressed and up-regulated in the high-density infiltrated immune cells but minimal in pancreatic cancerous cells. PMID: 29771768
    2. High VISTA expression is associated with colorectal carcinoma. PMID: 30128738
    3. VISTA expression supports immune-complex inflammation in collagen antibody-induced arthritis and VISTA is expressed in human synovium PMID: 29216931
    4. This study is the first to describe the expression of VISTA-expressing lymphocytes in melanoma samples and in the context of acquired resistance to immune checkpoint inhibitors PMID: 28776578
    5. Taken together, the results indicated that the VISTA high and CD8 low group, as an immunosuppressive subgroup, might be associated with a poor prognosis in primary OSCC. These findings indicated that VISTA might be a potential immunotherapeutic target in OSCC treatment. PMID: 28236118
    6. this review describes the functions of VISTA in the context of cancer immunotherapy PMID: 28258694
    7. overexpression of the newly described co-stimulatory molecule, PD1 homologue (PD-1H) in human monocyte/macrophages is sufficient to induce spontaneous secretion of multiple cytokines. PMID: 25279955
    8. p53-induced expression of DD1alpha prevents persistence of cell corpses and ensures efficient generation of precise immune responses in mice. PMID: 26228159
    9. Results suggest that GI24 contributes to tumor-invasive growth in the collagen matrix by augmenting cell surface MT1-MMP. PMID: 20666777

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  • 亞細(xì)胞定位：
    Cell membrane; Single-pass type I membrane protein.
  • 組織特異性：
    Expressed in spleen. Detected on a number of myeloid cells including CD11b monocytes, CD66b+ neutrophils, at low levels on CD4+ and CD8+ T-cells, and in a subset of NK cells. Not detected on B cells (at protein level). Expressed at high levels in placenta
  • 數(shù)據(jù)庫(kù)鏈接：

    HGNC: 30085

    OMIM: 615608

    KEGG: hsa:64115

    STRING: 9606.ENSP00000378409

    UniGene: Hs.47382



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