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  4. VSIR (HMBD-002 Biosimilar) Recombinant Monoclonal Antibody

VSIR (HMBD-002 Biosimilar) Recombinant Monoclonal Antibody

  • 貨號：
    CSB-RA884484MB1HU
  • 規(guī)格：
    ￥83486
  • 其他：

產品詳情

  • 產品描述：
    VSIR (HMBD-002 Biosimilar Antibody)重組單克隆抗體是一種專為科研用途開發(fā)的生物試劑。該抗體通過重組DNA技術制備，具有高度的特異性和生物活性，可作為生命科學研究中的重要工具。 作為重組單克隆抗體，VSIR (HMBD-002) 具有結構均一、批次間一致性高的特點，能夠為實驗研究提供可靠的結果。其獨特的分子設計使其在相關靶點研究中具有潛在的應用價值，適用于多種實驗體系。 在科研應用中，該抗體可用于探索VSIR相關信號通路的分子機制，助力免疫學、細胞生物學等領域的基礎研究。通過特異性識別靶分子，有助于深入解析相關生理和病理過程的分子調控網絡。 VSIR (HMBD-002 Biosimilar Antibody)重組單克隆抗體嚴格按照科研試劑標準生產，確保產品質量的穩(wěn)定性和可靠性。研究者可根據具體實驗需求，將其應用于等多種實驗技術，為生命科學研究提供有力支持。 該抗體僅用于科研目的，為生命科學領域的基礎研究和應用研究提供重要的實驗工具，有助于推動相關領域的科學探索和知識創(chuàng)新。
  • Uniprot No.：
  • 基因名：
  • 別名：
    anti-VISTA antibody - Hummingbird Bioscience research-grade biosimilar; HMBD 002 research-grade biosimilar; HMBD-002 research-grade biosimilar; HMBD-002-V4 research-grade biosimilar ;VSIR antibody; C10orf54 antibody; SISP1 antibody; VISTA antibody; PP2135 antibody; UNQ730/PRO1412 antibody; V-type immunoglobulin domain-containing suppressor of T-cell activation antibody; Platelet receptor Gi24 antibody; Stress-induced secreted protein-1 antibody; Sisp-1 antibody; V-set domain-containing immunoregulatory receptor antibody; V-set immunoregulatory receptor antibody
  • 反應種屬：
    Human
  • 免疫原：
    Recombinant Human VSIR protein
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated
  • 克隆類型：
    Monoclonal
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    0.01M PBS，pH7.4
  • 產品提供形式：
    Liquid
  • 應用說明：
    Validation Status
    Application-specific performance (e.g., in flow cytometry, ELISA, IHC or other assay formats) has not yet been experimentally verified by CUSABIO. Users are advised to determine the optimal working conditions empirically in their own assay systems.
    Guaranteed Quality
    ① Antibody purity?> 95% tested by SDS-PAGE.
    ② Endotoxin level < 0.1EU/ug tested by LAL method.
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    3-4 weeks
  • 用途：
    It is a non-therapeutic biosimilar antibody, owning the same variable region from the corresponding approved therapeutic antibody. In conclusion, it is a research-grade biosimilar antibody and expressed in mammalian cell, which can be directly used as positive controls in drug discovery or used for rapid verification of the biological functions of target protein.

產品評價

靶點詳情

  • 功能：
    Immunoregulatory receptor which inhibits the T-cell response. May promote differentiation of embryonic stem cells, by inhibiting BMP4 signaling. May stimulate MMP14-mediated MMP2 activation.
  • 基因功能參考文獻：
    1. Data indicate that VISTA is predominantly expressed and up-regulated in the high-density infiltrated immune cells but minimal in pancreatic cancerous cells. PMID: 29771768
    2. High VISTA expression is associated with colorectal carcinoma. PMID: 30128738
    3. VISTA expression supports immune-complex inflammation in collagen antibody-induced arthritis and VISTA is expressed in human synovium PMID: 29216931
    4. This study is the first to describe the expression of VISTA-expressing lymphocytes in melanoma samples and in the context of acquired resistance to immune checkpoint inhibitors PMID: 28776578
    5. Taken together, the results indicated that the VISTA high and CD8 low group, as an immunosuppressive subgroup, might be associated with a poor prognosis in primary OSCC. These findings indicated that VISTA might be a potential immunotherapeutic target in OSCC treatment. PMID: 28236118
    6. this review describes the functions of VISTA in the context of cancer immunotherapy PMID: 28258694
    7. overexpression of the newly described co-stimulatory molecule, PD1 homologue (PD-1H) in human monocyte/macrophages is sufficient to induce spontaneous secretion of multiple cytokines. PMID: 25279955
    8. p53-induced expression of DD1alpha prevents persistence of cell corpses and ensures efficient generation of precise immune responses in mice. PMID: 26228159
    9. Results suggest that GI24 contributes to tumor-invasive growth in the collagen matrix by augmenting cell surface MT1-MMP. PMID: 20666777

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  • 亞細胞定位：
    Cell membrane; Single-pass type I membrane protein.
  • 組織特異性：
    Expressed in spleen. Detected on a number of myeloid cells including CD11b monocytes, CD66b+ neutrophils, at low levels on CD4+ and CD8+ T-cells, and in a subset of NK cells. Not detected on B cells (at protein level). Expressed at high levels in placenta
  • 數據庫鏈接：

    HGNC: 30085

    OMIM: 615608

    KEGG: hsa:64115

    STRING: 9606.ENSP00000378409

    UniGene: Hs.47382



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