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  4. TSPAN8 (US9487586B2 Biosimilar) Recombinant Monoclonal Antibody

TSPAN8 (US9487586B2 Biosimilar) Recombinant Monoclonal Antibody

  • 貨號(hào)：
    CSB-RA025166MB1HU
  • 規(guī)格：
    ￥83486
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品描述：
    TSPAN8 (US9487586B2 Biosimilar Antibody) 重組單克隆抗體是一種針對(duì)跨膜四蛋白超家族成員3（TSPAN8），其別包括anti TSPAN8 antibody、CO029 antibody、Tetraspanin 8 antibody、TM4SF3 antibody、TSN8_HUMAN antibody等多種名稱，反映了其在不同研究場(chǎng)景中的標(biāo)識(shí)習(xí)慣。該抗體以重組人TSPAN8蛋白制備，具有高度的種屬反應(yīng)特異性，僅針對(duì)人類TSPAN8蛋白產(chǎn)生免疫結(jié)合活性。 TSPAN8作為一種腫瘤相關(guān)抗原，其高表達(dá)與多種惡性腫瘤的發(fā)生發(fā)展密切相關(guān)，尤其在胰腺癌、結(jié)直腸癌、卵巢癌等上皮源性腫瘤中被廣泛關(guān)注。針對(duì)TSPAN8類似物在臨床研究中，主要探索其在晚期實(shí)體瘤治療中的應(yīng)用，包括單藥治療或聯(lián)合化療方案以評(píng)估安全性與療效，同時(shí)其在腫瘤早期診斷標(biāo)志物領(lǐng)域的應(yīng)用也在積極探索中。 該抗體是研究TSPAN8生物學(xué)功能的重要工具。在細(xì)胞生物學(xué)實(shí)驗(yàn)中，可用于檢測(cè)TSPAN8在腫瘤細(xì)胞表面的表達(dá)水平，染色觀察其亞細(xì)胞定位，以及免疫共沉淀探究其與其他膜蛋白的相互作用。在分子機(jī)制研究中，通過抗體阻斷或基因敲除/敲入技術(shù)相結(jié)合，有助于闡明TSPAN8在腫瘤微環(huán)境調(diào)控、細(xì)胞信號(hào)轉(zhuǎn)導(dǎo)（如Wnt/β-catenin、PI3K/Akt等通路）中的作用。此外，該抗體也可用于構(gòu)建荷瘤小鼠模型，評(píng)估靶向TSPAN8藥物的體內(nèi)抗腫瘤效果，為轉(zhuǎn)化醫(yī)學(xué)研究提供實(shí)驗(yàn)基礎(chǔ)。其高度的特異性和種屬反應(yīng)性確保了實(shí)驗(yàn)結(jié)果的可靠性，是腫瘤生物學(xué)、免疫學(xué)等領(lǐng)域研究的常用試劑。
  • Uniprot No.：
  • 基因名：
  • 別名：
    anti TSPAN8 antibody; CO029 antibody; Tetraspanin 8 antibody; Tetraspanin-8 antibody; TM4SF3 antibody; Transmembrane 4 superfamily member 3 antibody; TSN8_HUMAN antibody; Tspan 8 antibody; Tspan-8 antibody; TSPAN8 antibody; TSPAN8 antibody antibody; Tumor associated antigen CO 029 antibody; Tumor-associated antigen CO-029 antibody
  • 反應(yīng)種屬：
    Human
  • 免疫原：
    Recombinant Human TSPAN8 protein
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標(biāo)記方式：
    Non-conjugated
  • 克隆類型：
    Monoclonal
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    0.01M PBS，pH7.4
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用說明：
    Validation Status
    Application-specific performance (e.g., in flow cytometry, ELISA, IHC or other assay formats) has not yet been experimentally verified by CUSABIO. Users are advised to determine the optimal working conditions empirically in their own assay systems.
    Guaranteed Quality
    ① Antibody purity?> 95% tested by SDS-PAGE.
    ② Endotoxin level < 0.1EU/ug tested by LAL method.
  • 儲(chǔ)存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    In stock
  • 用途：
    It is a non-therapeutic biosimilar antibody, owning the same variable region from the corresponding approved therapeutic antibody. In conclusion, it is a research-grade biosimilar antibody and expressed in mammalian cell, which can be directly used as positive controls in drug discovery or used for rapid verification of the biological functions of target protein.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 基因功能參考文獻(xiàn)：
    1. TSPAN8 mediated Wnt/beta-catenin pathway through binding to NOTCH2. The role of TSPAN8 in the drug resistance of gastric cancer. PMID: 29345284
    2. these data point to a crucial role of Co-029 in the modulation of colon cancer cell motility which could be related to the protumoral effect reported for this tetraspanin. Among surface molecules able to mediate Co-029 function, E-cadherin, EGFR and CD44 appear as likely candidates. PMID: 28418857
    3. Single nucleotide polymorphism in TSPAN8 gene is associated with pathogenesis of bipolar disorder. PMID: 28777493
    4. Tetraspanin-8 has a role in promoting hepatocellular carcinoma metastasis by increasing ADAM12m expression PMID: 27270327
    5. LCMR1 modulation was sufficient to positively regulate endogenous Tspan8 expression, with concomitant in vitro phenotypic changes such as loss of melanoma cell-matrix adherence and increase in invasion, and Tspan8 expression promoted tumourigenicity in vivo. PMID: 27375018
    6. Data indicate a regulatory role for tetraspanin 8 (Tspan8) in melanoma progression by modulating cell-matrix interactions through beta1 integrin - integrin-linked kinase (ILK) axis and establish Tspan8 as a negative regulator of ILK activity. PMID: 28188308
    7. TSPAN8 might be important for the orchestration of meprin beta at the cell surface with impact on certain proteolytic processes PMID: 27180358
    8. Knocking down TSPAN8 in AEG-1-overexpressing human hepatocellular carcinoma (HCC) cells markedly inhibited invasion and migration without affecting proliferation. TSPAN8 knockdown profoundly abrogated AEG-1-induced primary tumor and intrahepatic metastasis in an orthopic xenograft model in athymic nude mice PMID: 27339400
    9. Knockdown and knockout models revealed that CD151 and Tspan8 act as molecular facilitators in wound healing, angiogenesis and tumor progression. [review] PMID: 28408484
    10. Results provide evidence that TSPAN8 may contribute to the pathogenesis of lung cancer by promoting cell viability and proliferation. PMID: 27996312
    11. TSPAN8 is involved in tumor progression and is an independent prognostic classifier in patients with gastric cancer. PMID: 25711980
    12. This novel nuclear localization of TM4SF3 depends on androgen-induced nuclear localization of androgen receptor (AR) in both androgen-dependent and androgen-independent prostate cancer cell lines PMID: 26649804
    13. Our data suggest that TSPAN8-LEL may play an important role in mCRC cell invasion, and that the antibody we have developed could be a useful tool for inhibiting the invasion of TSPAN8-expressing mCRCs. PMID: 26562525
    14. Based on nasopharyngeal TSPAN8 gene expression in readily available Nasopharyngeal aspirate samples , we can discriminate between severity of disease in Respiratory syncytial virus infected infants. PMID: 25261323
    15. Tspn8 was over-expressed in multiple clinical malignant glioma tissues, and its expression level correlated with the grade of tumors. PMID: 25680464
    16. CO-029 functions as a regulator of both cell-matrix and cell-cell adhesion. During colon cancer progression, CO-029 promotes cancer cell movement by deregulating cell adhesions. PMID: 22679508
    17. PMA-induced Tspan8-internalization promotes cell migration, but reduces matrix and cell adhesion. PMID: 20937409
    18. High TSPAN8 is associated with melanoma invasiveness. PMID: 21081927
    19. claudin-7-associated EpCAM is recruited into (tetraspanin-enriched membrane microdomains) and forms a complex with CO-029 and CD44v6 that facilitates metastasis formation PMID: 17579117
    20. overexpression of TM4SF3 in esophageal cancer conferred advantage to the invasion and metastasis of this destructive disease PMID: 18365756

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  • 亞細(xì)胞定位：
    Membrane; Multi-pass membrane protein.
  • 蛋白家族：
    Tetraspanin (TM4SF) family
  • 組織特異性：
    Gastric, colon, rectal, and pancreatic carcinomas.
  • 數(shù)據(jù)庫鏈接：

    HGNC: 11855

    OMIM: 600769

    KEGG: hsa:7103

    STRING: 9606.ENSP00000247829

    UniGene: Hs.170563



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