TNFRSF4 (STAR-0310 Biosimilar) Recombinant Monoclonal Antibody
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貨號:CSB-RA023981MB14HU
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規(guī)格:¥83486
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其他:
產(chǎn)品詳情
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產(chǎn)品描述:TNFRSF4 (STAR-0310 Biosimilar Antibody)重組單克隆抗體是一款專為科研用途開發(fā)的生物試劑,其靶點為腫瘤壞死因子受體超家族成員4(TNFRSF4),該受體在免疫調(diào)節(jié)、炎癥反應(yīng)及腫瘤微環(huán)境調(diào)控中具有重要作用。本產(chǎn)品通過基因工程技術(shù)在哺乳動物細胞表達系統(tǒng)中重組表達,經(jīng)多步純化工藝獲得高純度、高特異性的單克隆抗體,確保實驗結(jié)果的可靠性與可重復(fù)性。 該抗體可廣泛應(yīng)用于細胞生物學(xué)、分子免疫學(xué)及腫瘤學(xué)等研究領(lǐng)域。在基礎(chǔ)研究中,可用于某些實驗,以檢測TNFRSF4在不同細胞類型或組織中的表達水平及亞細胞定位;在功能研究中,可通過中和或激活TNFRSF4信號通路,探究其對T細胞活化、B細胞增殖及免疫耐受等生物學(xué)過程的調(diào)控機制;此外,在腫瘤免疫研究中,該抗體可作為工具試劑,助力解析TNFRSF4在腫瘤微環(huán)境中的作用,為開發(fā)新型免疫治療策略提供實驗依據(jù)。 產(chǎn)品嚴(yán)格按照科研試劑標(biāo)準(zhǔn)生產(chǎn),通過SDS-PAGE、HPLC等方法進行純度分析,經(jīng)ELISA及細胞活性實驗驗證其結(jié)合活性與特異性,批次間質(zhì)量穩(wěn)定。使用時需根據(jù)具體實驗需求優(yōu)化工作濃度,建議在-20℃條件下保存,避免反復(fù)凍融以保證抗體活性。本產(chǎn)品僅用于實驗室研究,不應(yīng)用于臨床診斷或治療。
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Uniprot No.:
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基因名:
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別名:ISB 830-X8 research-grade biosimilar; STAR 0310 research-grade biosimilar; STR-0310 research-grade biosimilar ;TNFRSF4 antibody; TXGP1L antibody; Tumor necrosis factor receptor superfamily member 4 antibody; ACT35 antigen antibody; OX40L receptor antibody; TAX transcriptionally-activated glycoprotein 1 receptor antibody; CD antigen CD134 antibody
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反應(yīng)種屬:Human
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免疫原:Recombinant Human TNFRSF4 protein
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免疫原種屬:Homo sapiens (Human)
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標(biāo)記方式:Non-conjugated
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克隆類型:Monoclonal
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濃度:It differs from different batches. Please contact us to confirm it.
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保存緩沖液:0.01M PBS,pH7.4
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產(chǎn)品提供形式:Liquid
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應(yīng)用說明:Validation Status
Application-specific performance (e.g., in flow cytometry, ELISA, IHC or other assay formats) has not yet been experimentally verified by CUSABIO. Users are advised to determine the optimal working conditions empirically in their own assay systems.
Guaranteed Quality
① Antibody purity?> 95% tested by SDS-PAGE.
② Endotoxin level < 0.1EU/ug tested by LAL method. -
儲存條件:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期:3-4 weeks
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用途:It is a non-therapeutic biosimilar antibody, owning the same variable region from the corresponding approved therapeutic antibody. In conclusion, it is a research-grade biosimilar antibody and expressed in mammalian cell, which can be directly used as positive controls in drug discovery or used for rapid verification of the biological functions of target protein.
相關(guān)產(chǎn)品
靶點詳情
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功能:Receptor for TNFSF4/OX40L/GP34. Is a costimulatory molecule implicated in long-term T-cell immunity.; (Microbial infection) Acts as a receptor for human herpesvirus 6B/HHV-6B.
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基因功能參考文獻:
- High OX40 expression in Ovarian carcinoma is correlated with chemosensitivity and improved recurrence free survival in Ovarian carcinoma . Patients might therefore benefit from a second line therapy. PMID: 29661166
- Increased OX40 expression is associated with gastric cancer. PMID: 29529339
- this study demonstrates that cSCCs contain an abundance of Tregs which can suppress tumoral effector T cell function and that activation of the costimulatory receptor OX40 enhances tumoral T cell responses. PMID: 27034329
- OX40 expression on T cells was positively associated with obesity in humans. PMID: 28612217
- Metabolically active CD4+ T cells expressing Glut1 and OX40 preferentially harbor HIV during in vitro infection. PMID: 28892135
- this study investigated whether CD134 is preferentially expressed on CD4 T cells in drug-induced hypersensitivity syndrome . PMID: 27174092
- blocking of both OX-40L and 4-1BBL reversed radiation-enhanced T-cell killing of human tumor targets as well as T-cell survival and activation. PMID: 26872462
- Low OX40 expression is associated with colorectal cancer. PMID: 26439988
- OX40 and its ligand are co stimulators for T lymphocytes. PMID: 26755473
- These studies provide the first direct evidence that ligation of tumour necrosis factor superfamily members and their cognate receptors is important for the control of viral lytic replication. PMID: 26467721
- Malaria patients and Plasmodium-infected rodents exhibit enhanced expression of the co-stimulatory receptor OX40 on CD4 T cells, which is abrogated following coordinate PD-1 co-inhibitory pathways, which are also upregulated during malaria. PMID: 25891357
- Identified two key amino acid residues within CD134 that are required for its interaction with herpesvirus 6B (HHV-6B) and for HHV-6B entry into cells. One of the residues (K79) allows access of the HHV-6B ligand to CD134. PMID: 26202244
- TL1A increases expression of CD25, LFA-1, CD134 and CD154, and induces IL-22 and GM-CSF production from effector CD4 T-cells PMID: 25148371
- High expression of OX40 is associated with type 1 diabetes. PMID: 24797972
- A cysteine-rich domain of CD134 that is critical for binding to the HHV-6B glycoprotein gH/gL/gQ1/gQ2 complex and HHV-6B infection. PMID: 25008928
- cirrhotic and hepatocellular carcinoma fragments moderately and highly infiltrated by Tregs, respectively, expressing OX40 PMID: 24756990
- data show that Ag-specific CD4(+) CD25(+) CD134(+) CD39(+) T cells are highly enriched for Treg cells, form a large component of recall responses and maintain a Treg-cell-like phenotype upon in vitro expansion. PMID: 24752698
- expression is associated with breast cancer in a stage dependent manner PMID: 23502335
- OX40 signals regulate CD8 T cell survival at least in part through maintaining expression of the anti-apoptotic molecule A1 PMID: 23936461
- Hyperactivation of the Akt pathway in Teff cells from children with lupus nephritis is associated with reduced induction of TRAF6 and up-regulation of OX40, which may cause Teff cell resistance to Treg cell-mediated suppression. PMID: 23896866
- This study identified OX40 as a key molecule and biomarker for rapid progression of HTLV-1-associated myelopathy/tropical spastic paraparesis. PMID: 23651542
- CD134 is a cellular receptor specific for human herpesvirus-6B entry. PMID: 23674671
- Head and neck cancer patients have decreased levels of alternative co-stimulatory receptors OX40 and 4-1BB. PMID: 22204816
- CD137 activity is directly proportional to colorectal cancer stage. Surgical resection of the tumor results in increased CD134 and CD137 expression PMID: 22343199
- We show that the inflammatory and cytotoxic function of CD4(+)CD28(null) T cells can be inhibited by blocking OX40 and 4-1BB costimulatory receptors. PMID: 22282196
- PAPP-A level was significantly related to soluble and membrane-bound OX40L in patients with ACS. PMID: 21111564
- Compared with control group, the expression of OX40 and Bcl-2 was significantly higher in allergic rhinitis. PMID: 19253527
- Transgenic OX40 forms a signaling complex in T cells that contains phosphoinositide 3-kinase (PI3K) and protein kinase B (PKB). PMID: 21289304
- High OX40 expression may be associated with malignant transformation, progression, invasion and metastasis in breast cancer biology. PMID: 20634005
- Possible proinflammatory effects of OX40L on the pathogenesis of atherosclerois. PMID: 21086790
- This study has shown that activation of OX40 induces CCL20 expression in the presence of antigen stimulation. PMID: 20400327
- The rs2298212G/A polymorphism in OX40 gene may be associated with the severity of coronary atherosclerotic disease. PMID: 20376799
- Data suggest the role of Perforin + cytotoxic T lymphocytes and CD134+ cells in the pathogenesis of autoimmunity of SLE. PMID: 20306696
- Pimecrolimus inhibits up-regulation of OX40 and synthesis of inflammatory cytokines upon secondary T cell activation by allogeneic dendritic cells. PMID: 12296857
- CD134 positive cells are identified within inflammatory lesions of active multiple sclerosis (MS), acute MS and chronic active MS as well as in acute disseminated leukoencephalitis patients. PMID: 14644025
- Mutagenesis showed that Asp60 and Asp62 are required for interaction with FIV, and modeling studies localized these two residues to the outer edge of domain 1 PMID: 15592478
- The expression of CD134 was markedly higher, compared to CD137, both on the day of the surgery and ten days after colorectal cancer surgery. PMID: 15638367
- Deficiencies in OX40 and CD30 signals were additive, secondary Ab responses were ablated.OX40/CD30 double-knockout OTII transgenic T cells fail to survive compared with normal T cells when cocultured with CD4(+)CD3(-) cells in vitro. PMID: 15778343
- Decrease in OX40 expression posttransplant includes the defective reconstitution of Treg cells, and the active inhibition of gene transcription by cyclosporine. PMID: 15808546
- stimulation of OX40/4-1BB rendered cells sensitive to apoptosis induced by TNF-alpha and reduced activation of NF-kappaB. OX40/4-1BB stimulation repressed the mitogen response in activated CD25+CD4+ T cells and preactivated CD8+ T cells PMID: 15941918
- CD3+ T lymphocytes co-expressing CD134 and CD137 antigens on peripheral blood revealed an increased percentages of OX-40/CD137 positive cells in patients with Graves' disease (p<0.025) compared to the controls. PMID: 16232366
- The relevance of these findings is supported by the vital functions fulfilled by OX40 in mammals as reflected by the high level of evolutionary conservation. PMID: 16329997
- The coexpression of CD25 and the costimulatory molecule CD134 on memory T-cells provides a novel marker for type 1 diabetes-associated T-cell immunity. PMID: 16380476
- OX40 ligation on CD4(+) T cells represents a potentially novel immunotherapeutic strategy that should be investigated to treat and prevent persistent virus infections, such as HIV-1 infection. PMID: 16456009
- OX40 is induced transiently on CD8(+) T cells upon activation and its signals contribute to both clonal expansion and functional reinforcement PMID: 16750861
- In the present study we found that costimulation via OX40 and TNF-R in OX40-expressing HIV-1-infected T cell lines leads to a marked reduction of HIV-1 production associated with rapid cell death. PMID: 18327975
- The expression of OX40 on CD4+ T cells in sentinel lymph nodes draining primary melanomas decreased withe more advanced tumor features, suggesting an immunosuppressive effect. PMID: 18374895
- Activity of OX40 ligand is enhanced by oligomerization and cell surface immobilization. PMID: 18397322
- the frequency of the most frequent haplotype, C-C-A-A, was significantly lower and that of the second most frequent, C-T-G-A, was significantly higher in hypertensive subjects than in controls. This difference was observed only in female patients PMID: 18398332
- These data offer a novel approach for UCB Treg expansion using aAPCs, including those coexpressing OX40L or 4-1BBL. PMID: 18645038
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相關(guān)疾病:Immunodeficiency 16 (IMD16)
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亞細胞定位:Membrane; Single-pass type I membrane protein.
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