TNFRSF18 (TRX-518 Biosimilar) Recombinant Monoclonal Antibody
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貨號:CSB-RA896537MB2HU
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規(guī)格:¥83486
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其他:
產(chǎn)品詳情
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產(chǎn)品描述:TNFRSF18(TRX-518 Biosimilar Antibody)重組單克隆抗體是一款專為科研用途開發(fā)的生物試劑,靶向腫瘤壞死因子受體超家族成員18(TNFRSF18)。該抗體通過基因工程技術重組表達,具備高特異性和親和力,可精準識別并結合TNFRSF18蛋白,為免疫調(diào)控機制研究提供可靠工具。 TNFRSF18作為重要的免疫檢查點分子,在T細胞活化、增殖及免疫耐受調(diào)節(jié)中發(fā)揮關鍵作用。該抗體的應用有助于深入探索其在腫瘤微環(huán)境、自身免疫疾病及抗感染免疫中的功能機制。研究人員可利用該試劑進行體外細胞實驗多種實驗,解析TNFRSF18相關信號通路的分子機制。 該產(chǎn)品采用重組單克隆抗體技術制備,確保了批次間的一致性和高純度,有效降低實驗背景干擾。其嚴格的質量控制流程包括蛋白純度檢測、結合活性驗證及內(nèi)毒素控制,滿足科研實驗對試劑穩(wěn)定性和可靠性的要求。適用于基礎免疫學、腫瘤免疫及藥物靶點發(fā)現(xiàn)等研究領域,為揭示免疫調(diào)節(jié)分子的生理病理功能提供有力支持。 通過特異性阻斷或激活TNFRSF18信號,該抗體可幫助研究人員闡明其在免疫應答中的調(diào)控網(wǎng)絡,為開發(fā)新型免疫治療策略提供理論依據(jù)。作為科研工具,其應用將推動對免疫調(diào)節(jié)機制的深入理解,助力相關疾病治療靶點的發(fā)現(xiàn)與驗證。
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Uniprot No.:
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基因名:
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別名:Anti-GITR-mAB research-grade biosimilar; Anti-GITR monoclonal antibody research-grade biosimilar; Anti-human-GITR-monoclonal-antibody research-grade biosimilar; Anti-TNFRSF18 monoclonal antibody research-grade biosimilar; TRX518 research-grade biosimilar; TRX 518 research-grade biosimilar ;TNFRSF18 antibody; AITR antibody; GITR antibody; UNQ319/PRO364 antibody; Tumor necrosis factor receptor superfamily member 18 antibody; Activation-inducible TNFR family receptor antibody; Glucocorticoid-induced TNFR-related protein antibody; CD antigen CD357 antibody
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反應種屬:Human
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免疫原:Recombinant Human TNFRSF18 protein
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免疫原種屬:Homo sapiens (Human)
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標記方式:Non-conjugated
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克隆類型:Monoclonal
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濃度:It differs from different batches. Please contact us to confirm it.
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保存緩沖液:0.01M PBS,pH7.4
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產(chǎn)品提供形式:Liquid
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應用說明:Validation Status
Application-specific performance (e.g., in flow cytometry, ELISA, IHC or other assay formats) has not yet been experimentally verified by CUSABIO. Users are advised to determine the optimal working conditions empirically in their own assay systems.
Guaranteed Quality
① Antibody purity?> 95% tested by SDS-PAGE.
② Endotoxin level < 0.1EU/ug tested by LAL method. -
儲存條件:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期:3-4 weeks
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用途:It is a non-therapeutic biosimilar antibody, owning the same variable region from the corresponding approved therapeutic antibody. In conclusion, it is a research-grade biosimilar antibody and expressed in mammalian cell, which can be directly used as positive controls in drug discovery or used for rapid verification of the biological functions of target protein.
相關產(chǎn)品
靶點詳情
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功能:Receptor for TNFSF18. Seems to be involved in interactions between activated T-lymphocytes and endothelial cells and in the regulation of T-cell receptor-mediated cell death. Mediated NF-kappa-B activation via the TRAF2/NIK pathway.
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基因功能參考文獻:
- HTLV-1 infection can modify the expression of main functional transcription factors, FOXP3 and GITR PMID: 28101786
- a novel molecular mechanism by which MBD4 inhibits GITR expression in a DNMT1-dependent manner PMID: 28542810
- Aberrant expression of GITR may contribute to systemic lupus erithematosus pathogenesis. Glucocorticoid may achieve its therapeutic effect partly by inducing GITR expression on Tresps rather than Tregs, which initiates the apoptosis of Tresp cells in SLE patients. PMID: 25293713
- GITR expression can enhance the sensitivity to Bortezomib by inhibiting Bortezomib-induced NF-kappaB activation. PMID: 25973846
- GITR is a crucial player in differentiation of thymic regulatory T cells and expansion of regulatory T cells, including both thymic regulatory T cells and peripheral regulatory T cells. PMID: 25961057
- Data may suggest a key role of regulatory GITR+CD25 low/-CD4+ T cells subset in the modulation of the abnormal immune response in lupus erythematosus (SLE) patients. PMID: 25256257
- results suggest that the GITR rs3753348 polymorphism may be involved in the development and susceptibility of CWP. PMID: 25445616
- these results show a higher susceptibility to apoptosis in patients' versus controls' T(reg) cells, suggesting that GITR is a T(reg)-cell marker that would be primarily involved in T(reg)-cell survival rather than in their suppressor function. PMID: 23929911
- Our findings indicate the possible involvement of GITR-GITRL pathway in the pathogenesis of pSS. PMID: 23935647
- GITR acts as a potential tumor suppressor in MM. PMID: 23785514
- Data indicate that the mRNAs of CTLA-4 and GITR genes were expressed at lower levels in CVID patients compared to control group. PMID: 23432692
- GITR is pathologically expressed on Treg cells in systemic lupus erythematosus. PMID: 22516990
- Liver tumor Tregs up-regulate the expression of glucocorticoid-induced tumor necrosis factor receptor compared with Tregs in tumor-free liver tissue and blood. PMID: 22911397
- Results suggest that GITR expression might indicate a molecular link between steroid use and complicated acute sigmoid diverticulitis. Increased MMP-9 expression by GITR signalling might explain morphological changes in the colonic wall in diverticulitis. PMID: 22309286
- The regulatory SNPs identified in this study will provide useful information for understanding the relevance of sequence polymorphisms in populations of different background and may serve as a basis to study parasite susceptibility in association studies PMID: 21445534
- GITRL may contribute to disease pathophysiology and resistance to direct and Rituximab-induced NK reactivity in CLL PMID: 22064350
- GITR, which transmits a signal that abrogates regulatory T cell functions, was elevated in early rheumatoid arthritis. PMID: 21670968
- DCs transfected with mRNA encoding a humanized anti-CTLA-4 mAb and mRNA encoding a soluble human GITR fusion protein enhance the induction of anti-tumor CTLs in response to DCs. PMID: 22028176
- Findings suggest that GITR-expression of TILs is associated with cancer progression. PMID: 21694467
- Although GITR transgene costimulation can therapeutically enhance T helper (Th) type 2 cell responses, GITR-GITR ligand interactions are not required for development of Th2-mediated resistance or pathology. PMID: 21705620
- Data indicate that CD4(+) CD25(low) GITR(+) cells represent a low percentage of the CD4(+) T-cell population (0.32-1.74%) and are mostly memory cells. PMID: 21557210
- study concludes, the rs3753348 C/G SNP in the GITR is associated with Hashimoto's disease prognosis and expression on T(reg) and T(eff) cells PMID: 21592113
- GITR rapidly recruits TNF receptor-associated factor 2 (TRAF2) in a ligand-dependent manner; data indicate that the cytoplasmic domain of GITR contains a single TRAF binding site where acidic residues 202/203 and 211-213 are critical for this interaction. PMID: 15944293
- Since regulatory T-cells are localized in the vicinity of GITRL-expressing cells in atopic dermatitis skin, the GITR/GITRL interaction may serve to perpetuate the inflammation locally. PMID: 16955181
- This protein has been shown to stimulate T cell-mediated antitumor immunity in mice, and now in a human tumor cell line. PMID: 17360848
- These data suggest that, despite abnormal GITR expression during HIV infection, GITR triggering enhances HIV-specific CD4(+) T cell cytokine expression and protects HIV-specific CD4(+) T cells from apoptosis. PMID: 17538882
- although GITR is an activation marker for NK cells similar to that for T cells, GITR serves as a negative regulator for NK cell activation PMID: 18230609
- CD4(+)CD25(+) effector memory T-cells expressing CD134 and GITR seem to play a role in disease mechanisms, as suggested by their close association with disease activity and their participation in the inflammatory process in Wegener's granulomatosis. PMID: 18723571
- mechanism of IgG4 induction by regulatory cells involves GITR-GITR-L interactions, IL-10 and TGF-beta. PMID: 18924213
- Data show that in humans GITRL expression subverts NK cell immunosurveillance of AML. PMID: 19155305
- mRNA level for CTLA-4, ICOS1, IL-23, IL-27, SMAD3 and GITR were lower in T regulatory cells of children with diabetes compared to the control patients PMID: 19547759
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亞細胞定位:[Isoform 1]: Cell membrane; Single-pass type I membrane protein.; [Isoform 2]: Secreted.
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組織特異性:Expressed in lymph node, peripheral blood leukocytes and weakly in spleen.
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