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TNFRSF18 (INCAGN1876 Biosimilar) Recombinant Monoclonal Antibody

  • 貨號:
    CSB-RA896537MB1HU
  • 規(guī)格:
    ¥83486
  • 其他:

產(chǎn)品詳情

  • 產(chǎn)品描述:
    TNFRSF18(INCAGN1876 Biosimilar Antibody)重組單克隆抗體是一種針對腫瘤壞死因子受體超家族成員18(TNFRSF18,又稱GITR)的重組單克隆抗體,專為科研用途設計。該抗體通過基因工程技術制備,具有高特異性和親和力,能夠精準識別并結合TNFRSF18受體,為免疫調(diào)節(jié)機制研究提供重要工具。 TNFRSF18作為免疫檢查點分子,在T細胞活化、增殖及免疫耐受調(diào)節(jié)中發(fā)揮關鍵作用。該受體的激活可增強效應T細胞功能,同時抑制調(diào)節(jié)性T細胞(Treg)的免疫抑制活性,從而調(diào)節(jié)抗腫瘤免疫應答。本產(chǎn)品可用于體外細胞實驗,如檢測受體表達、分析信號通路蛋白表達,或共培養(yǎng)體系中評估對T細胞增殖及細胞因子分泌的影響;也可用于體內(nèi)研究,通過動物模型探究其在腫瘤微環(huán)境或自身免疫疾病中的作用機制。 產(chǎn)品采用重組表達系統(tǒng)生產(chǎn),經(jīng)嚴格純化工藝去除雜質(zhì),確保高純度和低內(nèi)毒素水平,保障實驗結果的可靠性與重復性。其穩(wěn)定的理化性質(zhì)便于長期儲存和多次凍融使用,適用于多種免疫學實驗設計。作為科研工具,該抗體為深入探索TNFRSF18介導的免疫調(diào)節(jié)網(wǎng)絡、開發(fā)新型免疫治療策略提供了有力支持,尤其在腫瘤免疫、自身免疫性疾病及炎癥反應等領域的基礎研究中具有重要應用價值。
  • Uniprot No.:
  • 基因名:
  • 別名:
    INCAGN 01876 research-grade biosimilar; Ragifilimab research-grade biosimilar ;TNFRSF18 antibody; AITR antibody; GITR antibody; UNQ319/PRO364 antibody; Tumor necrosis factor receptor superfamily member 18 antibody; Activation-inducible TNFR family receptor antibody; Glucocorticoid-induced TNFR-related protein antibody; CD antigen CD357 antibody
  • 反應種屬:
    Human
  • 免疫原:
    Recombinant Human TNFRSF18 protein
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    Non-conjugated
  • 克隆類型:
    Monoclonal
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    0.01M PBS,pH7.4
  • 產(chǎn)品提供形式:
    Liquid
  • 應用說明:
    Validation Status
    Application-specific performance (e.g., in flow cytometry, ELISA, IHC or other assay formats) has not yet been experimentally verified by CUSABIO. Users are advised to determine the optimal working conditions empirically in their own assay systems.
    Guaranteed Quality
    ① Antibody purity?> 95% tested by SDS-PAGE.
    ② Endotoxin level < 0.1EU/ug tested by LAL method.
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    3-4 weeks
  • 用途:
    It is a non-therapeutic biosimilar antibody, owning the same variable region from the corresponding approved therapeutic antibody. In conclusion, it is a research-grade biosimilar antibody and expressed in mammalian cell, which can be directly used as positive controls in drug discovery or used for rapid verification of the biological functions of target protein.

產(chǎn)品評價

靶點詳情

  • 功能:
    Receptor for TNFSF18. Seems to be involved in interactions between activated T-lymphocytes and endothelial cells and in the regulation of T-cell receptor-mediated cell death. Mediated NF-kappa-B activation via the TRAF2/NIK pathway.
  • 基因功能參考文獻:
    1. HTLV-1 infection can modify the expression of main functional transcription factors, FOXP3 and GITR PMID: 28101786
    2. a novel molecular mechanism by which MBD4 inhibits GITR expression in a DNMT1-dependent manner PMID: 28542810
    3. Aberrant expression of GITR may contribute to systemic lupus erithematosus pathogenesis. Glucocorticoid may achieve its therapeutic effect partly by inducing GITR expression on Tresps rather than Tregs, which initiates the apoptosis of Tresp cells in SLE patients. PMID: 25293713
    4. GITR expression can enhance the sensitivity to Bortezomib by inhibiting Bortezomib-induced NF-kappaB activation. PMID: 25973846
    5. GITR is a crucial player in differentiation of thymic regulatory T cells and expansion of regulatory T cells, including both thymic regulatory T cells and peripheral regulatory T cells. PMID: 25961057
    6. Data may suggest a key role of regulatory GITR+CD25 low/-CD4+ T cells subset in the modulation of the abnormal immune response in lupus erythematosus (SLE) patients. PMID: 25256257
    7. results suggest that the GITR rs3753348 polymorphism may be involved in the development and susceptibility of CWP. PMID: 25445616
    8. these results show a higher susceptibility to apoptosis in patients' versus controls' T(reg) cells, suggesting that GITR is a T(reg)-cell marker that would be primarily involved in T(reg)-cell survival rather than in their suppressor function. PMID: 23929911
    9. Our findings indicate the possible involvement of GITR-GITRL pathway in the pathogenesis of pSS. PMID: 23935647
    10. GITR acts as a potential tumor suppressor in MM. PMID: 23785514
    11. Data indicate that the mRNAs of CTLA-4 and GITR genes were expressed at lower levels in CVID patients compared to control group. PMID: 23432692
    12. GITR is pathologically expressed on Treg cells in systemic lupus erythematosus. PMID: 22516990
    13. Liver tumor Tregs up-regulate the expression of glucocorticoid-induced tumor necrosis factor receptor compared with Tregs in tumor-free liver tissue and blood. PMID: 22911397
    14. Results suggest that GITR expression might indicate a molecular link between steroid use and complicated acute sigmoid diverticulitis. Increased MMP-9 expression by GITR signalling might explain morphological changes in the colonic wall in diverticulitis. PMID: 22309286
    15. The regulatory SNPs identified in this study will provide useful information for understanding the relevance of sequence polymorphisms in populations of different background and may serve as a basis to study parasite susceptibility in association studies PMID: 21445534
    16. GITRL may contribute to disease pathophysiology and resistance to direct and Rituximab-induced NK reactivity in CLL PMID: 22064350
    17. GITR, which transmits a signal that abrogates regulatory T cell functions, was elevated in early rheumatoid arthritis. PMID: 21670968
    18. DCs transfected with mRNA encoding a humanized anti-CTLA-4 mAb and mRNA encoding a soluble human GITR fusion protein enhance the induction of anti-tumor CTLs in response to DCs. PMID: 22028176
    19. Findings suggest that GITR-expression of TILs is associated with cancer progression. PMID: 21694467
    20. Although GITR transgene costimulation can therapeutically enhance T helper (Th) type 2 cell responses, GITR-GITR ligand interactions are not required for development of Th2-mediated resistance or pathology. PMID: 21705620
    21. Data indicate that CD4(+) CD25(low) GITR(+) cells represent a low percentage of the CD4(+) T-cell population (0.32-1.74%) and are mostly memory cells. PMID: 21557210
    22. study concludes, the rs3753348 C/G SNP in the GITR is associated with Hashimoto's disease prognosis and expression on T(reg) and T(eff) cells PMID: 21592113
    23. GITR rapidly recruits TNF receptor-associated factor 2 (TRAF2) in a ligand-dependent manner; data indicate that the cytoplasmic domain of GITR contains a single TRAF binding site where acidic residues 202/203 and 211-213 are critical for this interaction. PMID: 15944293
    24. Since regulatory T-cells are localized in the vicinity of GITRL-expressing cells in atopic dermatitis skin, the GITR/GITRL interaction may serve to perpetuate the inflammation locally. PMID: 16955181
    25. This protein has been shown to stimulate T cell-mediated antitumor immunity in mice, and now in a human tumor cell line. PMID: 17360848
    26. These data suggest that, despite abnormal GITR expression during HIV infection, GITR triggering enhances HIV-specific CD4(+) T cell cytokine expression and protects HIV-specific CD4(+) T cells from apoptosis. PMID: 17538882
    27. although GITR is an activation marker for NK cells similar to that for T cells, GITR serves as a negative regulator for NK cell activation PMID: 18230609
    28. CD4(+)CD25(+) effector memory T-cells expressing CD134 and GITR seem to play a role in disease mechanisms, as suggested by their close association with disease activity and their participation in the inflammatory process in Wegener's granulomatosis. PMID: 18723571
    29. mechanism of IgG4 induction by regulatory cells involves GITR-GITR-L interactions, IL-10 and TGF-beta. PMID: 18924213
    30. Data show that in humans GITRL expression subverts NK cell immunosurveillance of AML. PMID: 19155305
    31. mRNA level for CTLA-4, ICOS1, IL-23, IL-27, SMAD3 and GITR were lower in T regulatory cells of children with diabetes compared to the control patients PMID: 19547759

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  • 亞細胞定位:
    [Isoform 1]: Cell membrane; Single-pass type I membrane protein.; [Isoform 2]: Secreted.
  • 組織特異性:
    Expressed in lymph node, peripheral blood leukocytes and weakly in spleen.
  • 數(shù)據(jù)庫鏈接:

    HGNC: 11914

    OMIM: 603905

    KEGG: hsa:8784

    STRING: 9606.ENSP00000328207

    UniGene: Hs.212680



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