TNFRSF13C (ESG-206 Biosimilar) Recombinant Monoclonal Antibody
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貨號(hào):CSB-RA853495MB1HU
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規(guī)格:¥83486
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其他:
產(chǎn)品詳情
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產(chǎn)品描述:TNFRSF13C(ESG-206 Biosimilar Antibody)重組單克隆抗體是一種用于生命科學(xué)研究的生物試劑,專為靶向腫瘤壞死因子受體超家族成員13C(TNFRSF13C)設(shè)計(jì)。該抗體通過重組DNA技術(shù)在哺乳動(dòng)物細(xì)胞表達(dá)系統(tǒng)中制備,具有高純度、高特異性和批次間一致性的特點(diǎn),適用于多種實(shí)驗(yàn)場(chǎng)景。 TNFRSF13C作為重要的免疫調(diào)節(jié)分子,在B淋巴細(xì)胞發(fā)育、體液免疫應(yīng)答及相關(guān)疾病機(jī)制中發(fā)揮關(guān)鍵作用。本產(chǎn)品可通過特異性結(jié)合TNFRSF13C胞外結(jié)構(gòu)域,用于研究其信號(hào)通路激活、受體-配體相互作用及下游生物學(xué)效應(yīng)。實(shí)驗(yàn)應(yīng)用包括但不限于受體結(jié)合分析等。 該抗體經(jīng)過嚴(yán)格的質(zhì)量控制,包括SDS-PAGE純度檢測(cè)(≥95%)、 endotoxin含量測(cè)定(<0.1 EU/μg)及功能性驗(yàn)證,確保科研結(jié)果的可靠性與可重復(fù)性。產(chǎn)品提供液體形式,推薦儲(chǔ)存于-20℃條件下,避免反復(fù)凍融,保質(zhì)期為12個(gè)月。 本試劑僅用于實(shí)驗(yàn)室研究,不用于診斷或治療用途。通過使用TNFRSF13C重組單克隆抗體,研究人員可深入探索免疫調(diào)節(jié)機(jī)制、自身免疫性疾病及B細(xì)胞相關(guān)腫瘤的分子基礎(chǔ),為免疫學(xué)研究及藥物靶點(diǎn)發(fā)現(xiàn)提供有力工具。
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Uniprot No.:
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基因名:
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別名:ESG206 research-grade biosimilar; ESG 206 research-grade biosimilar ;TNFRSF13C antibody; BAFFR antibody; BR3 antibody; Tumor necrosis factor receptor superfamily member 13C antibody; B-cell-activating factor receptor antibody; BAFF receptor antibody; BAFF-R antibody; BLyS receptor 3 antibody; CD antigen CD268 antibody
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反應(yīng)種屬:Human
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免疫原:Recombinant Human TNFRSF13C protein
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免疫原種屬:Homo sapiens (Human)
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標(biāo)記方式:Non-conjugated
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克隆類型:Monoclonal
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濃度:It differs from different batches. Please contact us to confirm it.
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保存緩沖液:0.01M PBS,pH7.4
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產(chǎn)品提供形式:Liquid
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應(yīng)用說明:Validation Status
Application-specific performance (e.g., in flow cytometry, ELISA, IHC or other assay formats) has not yet been experimentally verified by CUSABIO. Users are advised to determine the optimal working conditions empirically in their own assay systems.
Guaranteed Quality
① Antibody purity?> 95% tested by SDS-PAGE.
② Endotoxin level < 0.1EU/ug tested by LAL method. -
儲(chǔ)存條件:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期:3-4 weeks
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用途:It is a non-therapeutic biosimilar antibody, owning the same variable region from the corresponding approved therapeutic antibody. In conclusion, it is a research-grade biosimilar antibody and expressed in mammalian cell, which can be directly used as positive controls in drug discovery or used for rapid verification of the biological functions of target protein.
相關(guān)產(chǎn)品
靶點(diǎn)詳情
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功能:B-cell receptor specific for TNFSF13B/TALL1/BAFF/BLyS. Promotes the survival of mature B-cells and the B-cell response.
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基因功能參考文獻(xiàn):
- the B-cell receptor BR3 modulates cellular branching via Rac1 during neuronal migration PMID: 27436754
- Expression patterns of BAFF and its receptor BAFF-R differ according to lupus nephritis class. PMID: 29087261
- up-regulated expression in intractable temporal lobe epilepsy PMID: 28441631
- Inhibition of ADAM10 augments BAFF-dependent survival of primary human B cells, whereas inhibition of ADAM17 increases BAFFR expression levels. PMID: 28249164
- Relationships between serum BAFF and BBR expression [(BAFFR, calcium signal modulating cyclophilic ligand interactor (TACI) and B cell maturation antigen (BCMA)] were determined on B cell subsets, defined using immunoglobulin (Ig)D/CD38. Twenty pre-RTX and 18 rheumatoid arthritis patients relapsing after B cell depletion were included. PMID: 28800164
- Among the BAFF receptors in a cohort of rheumatoid arthritis (RA) patients, the AA have shown, by fluorescence activated cell sorter (FACS) analysis of median fluorescence intensity (MFI), that transmembrane activator and calcium-modulating cyclophilin ligand interactor (TACI) and B cell maturation antigen (BCMA) do not change PMID: 28834574
- The expression levels of serum BAFF and the three receptors (TACI, BCMA and BAFF-R) in non-Hodgkin lymphoma patients were significantly higher than in healthy controls. PMID: 28028945
- Variants in BAFF-R gene is associated with chronic lymphocytic leukemia. PMID: 27468724
- BAFF-R, as the principal receptor of BAFF, not only decreased the apoptosis of B cells and CD8+ T cells by upregulating the expression of Bcl-2 and BclxL, but also promoted B-cell proliferation in immune thrombocytopenia. PMID: 26749059
- genetic polymorphism contributes to the pathogenesis of primary antibody deficiency PMID: 26613719
- BAFF and BAFF-R are expressed in the thyrocytes derived from patients with either autoimmune thyroid disorders or multinodular goiter, as well in the infiltrating immune cells of Graves' disease and Hashimoto's thyroiditis PMID: 26214745
- There is an increased prevalence of the BAFF-R His159Tyr mutation in patients with Sjogren's syndrome (SS), particularly in those with SS complicated by MALT lymphoma whose disease onset occurred at a younger age. PMID: 26097183
- Expression of mutant caspase-9 correlated with a downregulation of BAFFR (B-cell-activating factor belonging to the TNF family (BAFF) receptor) in B cells and ICOS (inducible T-cell costimulator) in T cells. PMID: 25569260
- Variants of TNFRSF13C were associated with common variable immunodeficiency. PMID: 26122175
- Negative expression of BAFF-R, but not of BAFF, could be an independent risk factor for progression-free survival and Overall survival in patients with diffuse large B-cell lymphoma treated with standard R-CHOP. PMID: 26327569
- the common TLR4-D299G, TLR4-T399I and BAFFR-P21R polymorphisms provide the carriers with a protective advantage against ICU-acquired sepsis; this finding was more profound for medical patients compared to trauma or surgical ones PMID: 25454804
- Data show significant differences in expression of tumour necrosis factor family (BAFF) receptors BAFF-R, BCMA and TACI in patients with and without anti-Jo-1 or anti-Ro52/anti-Ro60 autoantibodies. PMID: 25301447
- In view of the restricted expression of the BAFF-R on normal cells and the multiple anti-pre-B ALL activities stimulated by this antibody, a further examination of its use for treatment of pre-B ALL is warranted. PMID: 24825858
- Availability of BAFF determines BAFF-R and TACI expression on B cells in common variable immunodeficiency. PMID: 24809296
- Our study demonstrates that BR3 is involved in the survival of cultured epithelial cells due to an autocrine effect of BAFF. PMID: 24602383
- BAFF-R, but not BAFF, may have a role in progression-free survival and overall survival in follicular lymphoma PMID: 23272079
- BLyS and its receptors are expressed by B lymphocytes in the peripheral blood and the bone marrow of patients with multiple myeloma. PMID: 23276925
- P21R/H159Y TNFRSF13C compound heterozygous mutation and P21R heterozygous mutations were detected in Turkish patients with common variable immunodeficiency. PMID: 22699762
- BAFF-R expression is tightly regulated during B-cell development in mouse and human and this exprssion is correlated with posirive selection. PMID: 22028296
- It was also found that NF-kappaB was an important transcription factor involved in regulating BAFF-R expression through one NF-kappaB binding site in the BAFF-R promoter PMID: 21607696
- Soluble BAFF levels inversely correlate with peripheral B cell numbers and the expression of BAFF receptors. PMID: 22124120
- The activation profile of diffuse large B-cell lymphomas/posttransplantation lymphoproliferative disorders was not associated with BAFF/BAFF-R expression, whereas nuclear p52 activation might be linked to Epstein-Barr virus. PMID: 21871426
- The human BAFF-R gene might be regulated via a transcriptional event through one putative NF-kappaB site on the BAFF-R gene promoter. PMID: 21744373
- reduced expression via inhibition of the NF-KappaB pathway in B cells of rheumatoid arthritis patients PMID: 21515993
- primary leukemia B-cell precursors aberrantly express receptors of the BAFF-system, BAFF-R, BCMA, and TACI PMID: 21687682
- This is the first study, presenting together the TNFSF members APRIL, BAFF, TWEAK and their receptors in different areas of normal renal tissue and renal cell carcinoma. PMID: 21483105
- BLyS and its receptors might have a potential role in the growth and survival of malignant plasma cells. PMID: 19731825
- Results describe the mechanisms underlying aberrant BAFF-R expression in precursor B acute lymphoblastic leukemia (precursor B-ALL) and mature B chronic lymphocytic leukemia (CLL). PMID: 21099364
- BAFF-R was rather specifically related to low growth activity of germinal center B-cell-like -type diffuse large B-cell lymphoma of nodal origin. PMID: 21123970
- inverse correlation between BAFF and APRIL in Kawasaki disease is reversed by IVIG treatment PMID: 20945608
- Elevated plasma BAFF and reduced BAFF receptor 3 (BR3) protein expression on peripheral B cells could act as biomarkers for active disease in systemic lupus erythematosus patients PMID: 20974656
- a novel lymphoma-associated mutation in human BAFF-R that results in NF-kappaB activation and reveals TRAF6 as a necessary component of normal BAFF-R signaling. PMID: 21041452
- Data from BAFF-R-expressing cells suggested potential regulatory sites in TNFRSF13C promoter region. PMID: 20554963
- This report is the first showing universal expression of BAFF-R by pre-B ALL cells. PMID: 20460528
- IFN-gamma and the NF-kappaB pathway could be involved in regulating the transcription and mRNA expression of BAFF-R gene. PMID: 20230666
- the mechanism of transcriptional regulation of BAFF-R PMID: 20025535
- BAFF-R is a receptor for the TNF family member ligand, BAFF [review] PMID: 12456020
- BAFFR-mediated NF-kappa B activation and IL-10 production in B cells is downregulated by TNFR-associated factor-3. PMID: 12471121
- crystal structure and interaction with BAFF protein PMID: 12715002
- BAFF/BLyS receptor 3 comprises a minimal TNF receptor-like module that encodes a highly focused ligand-binding site. PMID: 12755599
- Expression of BCMA, TACI, and BAFF-R by multiple myeloma cells support cell growth and survival. PMID: 14512299
- This study reports the crystal structure of a 24-residue fragment of the cytoplasmic portion of BAFF-R bound in complex with TRAF3. PMID: 15585864
- the PVPAT sequence of BAFFR not only functions as a key signaling motif of BAFFR but also determines its signaling specificity in the induction of the noncanonical NF-kappaB pathway PMID: 15644327
- amino acid sequence of genomic DNA from blood of common variable immunodeficiency patients;mutations may result in humoral immunodeficiency PMID: 16160919
- BAFF-R is expressed on most mature B cells and B-cell lymphoproliferative disorders. PMID: 16226112
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相關(guān)疾病:Immunodeficiency, common variable, 4 (CVID4)
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亞細(xì)胞定位:Membrane; Single-pass type III membrane protein.
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組織特異性:Highly expressed in spleen and lymph node, and in resting B-cells. Detected at lower levels in activated B-cells, resting CD4+ T-cells, in thymus and peripheral blood leukocytes.
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