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  4. TM4SF1 (US11208495B2 Biosimilar) Recombinant Monoclonal Antibody

TM4SF1 (US11208495B2 Biosimilar) Recombinant Monoclonal Antibody

  • 貨號(hào)：
    CSB-RA023615MB1HU
  • 規(guī)格：
    ￥83486
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品描述：
    TM4SF1（US 11,208,495 B2 Biosimilar Antibody）重組單克隆抗體是一種針對(duì)跨膜蛋白4L6家族成員1（TM4SF1）的生物治療藥物，其別名為M3S1抗體、膜成分染色體3表面標(biāo)志物1抗體、T4S1_HUMAN抗體、TAAL6抗體、Tm4sf1抗體及腫瘤相關(guān)抗原L6抗體。該抗體以重組人源TM4SF1蛋白制備，具有高度的種屬反應(yīng)性，主要針對(duì)人類TM4SF1蛋白發(fā)揮作用。 TM4SF1作為一種腫瘤相關(guān)抗原，在多種惡性腫瘤中高表達(dá)，與腫瘤細(xì)胞的增殖、侵襲和轉(zhuǎn)移密切相關(guān)。相關(guān)研究表明，針對(duì)TM4SF1抗體的類似物可通過特異性作用于腫瘤細(xì)胞表面的TM4SF1蛋白，抑制腫瘤細(xì)胞的信號(hào)傳導(dǎo)通路，從而發(fā)揮抗腫瘤活性。目前，針對(duì)該靶點(diǎn)類似物已進(jìn)入臨床前研究及早期臨床試驗(yàn)階段，初步結(jié)果顯示其在抑制實(shí)體瘤生長(zhǎng)和減少遠(yuǎn)處轉(zhuǎn)移方面具有潛在應(yīng)用價(jià)值，有望成為腫瘤靶向治療的新候選藥物。 TM4SF1重組單克隆抗體是研究TM4SF1蛋白功能的重要工具。由于其來源于重組人源TM4SF1蛋白，且種屬反應(yīng)性限定為人類，適用于人類細(xì)胞系、組織樣本中TM4SF1蛋白的檢測(cè)與定位，如、（Immunofluorescence）實(shí)驗(yàn)。此外，該抗體還可用于探索TM4SF1在腫瘤微環(huán)境調(diào)控、血管生成及腫瘤干細(xì)胞維持中的作用機(jī)制，為深入理解TM4SF1的生理病理功能提供支持，同時(shí)也為基于TM4SF1靶點(diǎn)類似物開發(fā)提供實(shí)驗(yàn)基礎(chǔ)。
  • Uniprot No.：
  • 基因名：
  • 別名：
    M3S1 antibody; Membrane component chromosome 3 surface marker 1 antibody; T4S1_HUMAN antibody; TAAL6 antibody; Tm4sf1 antibody; Transmembrane 4 L6 family member 1 antibody; Tumor-associated antigen L6 antibody
  • 反應(yīng)種屬：
    Human
  • 免疫原：
    Recombinant Human TM4SF1 protein
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標(biāo)記方式：
    Non-conjugated
  • 克隆類型：
    Monoclonal
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    0.01M PBS，pH7.4
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用說明：
    Validation Status Application-specific performance (e.g., in flow cytometry, ELISA, IHC or other assay formats) has not yet been experimentally verified by CUSABIO. Users are advised to determine the optimal working conditions empirically in their own assay systems. Guaranteed Quality ① Antibody purity?> 95% tested by SDS-PAGE. ② Endotoxin level < 0.1EU/ug tested by LAL method.
  • 儲(chǔ)存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    In stock
  • 用途：
    It is a non-therapeutic biosimilar antibody, owning the same variable region from the corresponding approved therapeutic antibody. In conclusion, it is a research-grade biosimilar antibody and expressed in mammalian cell, which can be directly used as positive controls in drug discovery or used for rapid verification of the biological functions of target protein.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 基因功能參考文獻(xiàn)：
    1. our study provides a novel regulatory pathway involving TM4SF1, DDR1, MMP2 and MMP9, which promotes the formation and function of invadopodia to support cell migration and invasion in pancreatic cancer. PMID: 28368050
    2. Regulation of transmembrane-4-L-six-family-1 (TM4SF1) on bladder cancer cell could be induced by peroxisome proliferator-activated receptor gamma (PPARgamma)-sirtuin 1 (SIRT1) feedback loop. PMID: 29175458
    3. TM4SF1 was recognized as a direct target for miR-520f in hepatocellular carcinoma (HCC) cells where its expression was found up-regulated and inversely correlated with that of mir-520f. PMID: 29505836
    4. Results suggest that miR-30a is an important regulator of TM4SF1, VEGF, and E-cadherin for CRC lymph node metastasis, a potential new therapeutic target in CRC. PMID: 28528497
    5. High TM4SF1 expression is associated with esophageal cancer. PMID: 27974706
    6. Replacement of the transmembrane 4 L six family protein TM4SF1 or TM4SF4 C-terminus with that of TM4SF5 increased spheroids growth, transwell migration, and invasive dissemination from spheroids in 3D collagen gels. PMID: 28129652
    7. Results indicate that the expression of transmembrane 4 L6 family member 1 (TM4SF1) is higher in pancreatic cancer tissues and pancreatic cancer cell lines than controls. PMID: 27459514
    8. Results show that TM4SF1 expression is elevated in colorectal cancer (CRC), and associated with tumor stage and lymph node metastasis. Also, miR-9 directly targeted its binding site in the TM4SF1 3'-UTR, which has a critical role in regulating CRC cell migration. and invasion. Furthermore, miR-9 regulated cell motility via suppressing PMID: 26983891
    9. The findings suggest that TM4SF1 is a surface membrane antigen that is highly expressed in pancreatic cancer cells and increases the chemoresistance to gemcitabine. TM4SF1 may be a promising target to overcome the chemoresistance of pancreatic cancer. PMID: 26709920
    10. TM4SF1 overexpression significantly contributed MDA-MB-231 cell migration but decreased apoptotic cells PMID: 26464650
    11. Study shows that TM4SF1 expression is associated with better prognosis in pancreatic cancer. Its loss contributes to the invasion and migration of pancreatic cancer cells. PMID: 26035794
    12. We found that miR-203 was significantly downregulated in OSF tissues compared to that in normal buccal mucosa tissues, and that miR-203 negatively regulated secreted SFRP4 and positively regulated TM4SF1 PMID: 25872484
    13. Transmembrane-4-L-six-family-1 is overexpressed in human gliomas in general and the precise level of expression might predict outcome and could be of clinical value. PMID: 25855954
    14. These findings validate TM4SF1 as an attractive candidate for cancer therapy with antibody-bound toxins that have the capacity to react with either cytoplasmic or nuclear targets in tumor cells or tumor-associated vascular endothelium. PMID: 26241677
    15. TM4SF1 is a small plasma membrane glycoprotein that regulates cell motility and proliferation, and possibly a new vascular therapeutic target in cancer PMID: 24986520
    16. High TM4SF1 expression is associated with pancreatic cancer. PMID: 24285464
    17. TM4SF1, like genuine tetraspanins, serves as a molecular organizer that interacts with membrane and cytoskeleton-associated proteins and uniquely initiates the formation of nanopodia and facilitates cell polarization and migration. PMID: 21626280
    18. We provide evidence that ARHGDIA, COBLL1, and TM4SF1 are negative regulators of apoptosis in cultured tumor cells. PMID: 21569526
    19. Inhibition of cell migration after targeted knockdown of TM4SF1 protein expression suggests its contribution to prostate cancer cell metastasis. PMID: 21656834
    20. TM4SF1 can serve as a surface protein marker which singly identifies MSCs from diverse cell sources, in particular, fibroblast-rich connective tissues PMID: 20486778
    21. TAL6 may play a role in cancer invasion and metastasis PMID: 12855661
    22. These data suggest that L6-Ag influences cell motility via TERM by regulating the surface presentation and endocytosis of some of their components. PMID: 18270265
    23. The gene ratio test with the TM4SF1 gene for survival of patients with malignant pleural mesothelioma has robust predictive value. PMID: 19401544

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  • 亞細(xì)胞定位：
    Membrane; Multi-pass membrane protein.
  • 蛋白家族：
    L6 tetraspanin family
  • 組織特異性：
    Highly expressed in lung, breast, colon and ovarian carcinomas. It is also present on some normal cells, endothelial cells in particular.
  • 數(shù)據(jù)庫鏈接：

    HGNC: 11853

    OMIM: 191155

    KEGG: hsa:4071

    STRING: 9606.ENSP00000304277

    UniGene: Hs.351316



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