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  4. STAB1 (Bexmarilimab Biosimilar) Recombinant Monoclonal Antibody

STAB1 (Bexmarilimab Biosimilar) Recombinant Monoclonal Antibody

  • 貨號(hào)：
    CSB-RA865173MB1HU
  • 規(guī)格：
    ￥83486
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品描述：
    STAB1 (Bexmarilimab Biosimilar Antibody)重組單克隆抗體是一種用于科研領(lǐng)域的生物制劑。該產(chǎn)品通過重組DNA技術(shù)制備，具有高度特異性的靶向結(jié)合能力，為生命科學(xué)研究提供了重要工具。 作為單克隆抗體，STAB1能夠精準(zhǔn)識(shí)別并結(jié)合特定的抗原表位，在生物醫(yī)學(xué)研究中可用于蛋白質(zhì)檢測(cè)、細(xì)胞分選等多種實(shí)驗(yàn)應(yīng)用。其單克隆特性保證了批次間的一致性和實(shí)驗(yàn)結(jié)果的可靠性，有助于提高科研數(shù)據(jù)的重復(fù)性和準(zhǔn)確性。 該重組抗體的研發(fā)基于現(xiàn)代生物技術(shù)平臺(tái)，通過優(yōu)化的表達(dá)系統(tǒng)和純化工藝，確保產(chǎn)品具有高純度和高活性。在科研應(yīng)用中，可廣泛用于免疫學(xué)、細(xì)胞生物學(xué)、腫瘤學(xué)等研究領(lǐng)域，助力科學(xué)家深入探索疾病機(jī)制、開發(fā)新的研究方法。 STAB1 (Bexmarilimab Biosimilar Antibody)重組單克隆抗體為科研人員提供了一種可靠的實(shí)驗(yàn)工具，支持從基礎(chǔ)研究到應(yīng)用研究的多個(gè)科學(xué)探索方向，推動(dòng)生命科學(xué)領(lǐng)域的知識(shí)創(chuàng)新和技術(shù)發(fā)展。
  • Uniprot No.：
  • 基因名：
  • 別名：
    Anti-clever-1 monoclonal antibody FP-1305 research-grade biosimilar; Clevegen research-grade biosimilar; FP1305 research-grade biosimilar; FP-1305 research-grade biosimilar ;STAB1 antibody; FEEL1 antibody; KIAA0246 antibody; Stabilin-1 antibody; Fasciclin, EGF-like, laminin-type EGF-like and link domain-containing scavenger receptor 1 antibody; FEEL-1 antibody; MS-1 antigen antibody
  • 反應(yīng)種屬：
    Human
  • 免疫原：
    Recombinant Human STAB1 protein
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標(biāo)記方式：
    Non-conjugated
  • 克隆類型：
    Monoclonal
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    0.01M PBS，pH7.4
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用說明：
    Validation Status
    Application-specific performance (e.g., in flow cytometry, ELISA, IHC or other assay formats) has not yet been experimentally verified by CUSABIO. Users are advised to determine the optimal working conditions empirically in their own assay systems.
    Guaranteed Quality
    ① Antibody purity?> 95% tested by SDS-PAGE.
    ② Endotoxin level < 0.1EU/ug tested by LAL method.
  • 儲(chǔ)存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    3-4 weeks
  • 用途：
    It is a non-therapeutic biosimilar antibody, owning the same variable region from the corresponding approved therapeutic antibody. In conclusion, it is a research-grade biosimilar antibody and expressed in mammalian cell, which can be directly used as positive controls in drug discovery or used for rapid verification of the biological functions of target protein.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能：
    Acts as a scavenger receptor for acetylated low density lipoprotein. Binds to both Gram-positive and Gram-negative bacteria and may play a role in defense against bacterial infection. When inhibited in endothelial tube formation assays, there is a marked decrease in cell-cell interactions, suggesting a role in angiogenesis. Involved in the delivery of newly synthesized CHID1/SI-CLP from the biosynthetic compartment to the endosomal/lysosomal system.
  • 基因功能參考文獻(xiàn)：
    1. Satb1 promotes osteoclastogenesis by recruiting CREB-binding protein to upregulate miR-223 expression in chronic kidney disease-mineral and bone disorder PMID: 29442043
    2. Systemic rAAV-DCN in neuroblastoma-grafted nude mice inhibited stabilin-1. PMID: 28631095
    3. Results suggest stabilin-1 mediated silent clearance of extracellular tumor growth-inhibiting factors as a mechanism of stabilin-1 induced tumor growth. PMID: 27105498
    4. These data define stabilin-1 as a new immunosuppressive molecule and suggest that stabilin-1(high) monocytes may dampen proinflammatory reactions in vivo. PMID: 26608916
    5. The present findings suggest that STAB1 is a new and highly promising candidate gene in this region. The combining of gene expression and GWAS data may provide valuable insights into the biological mechanisms of BD. PMID: 25136889
    6. Genes within recently identified loci associated with waist-hip ratio (WHR) exhibit fat depot-specific mRNA expression, which correlates with obesity-related traits. Adipose tissue (AT) mRNA expression of 6 genes (TBX15/WARS2, STAB1, PIGC, ZNRF3, GRB14 PMID: 23670221
    7. The associations between CLEVER-1 expression on endothelial vessels and macrophage/leukocyte infiltration is suggestive of its regulation by inflammatory conditions in breast cancer, most likely by macrophage-associated cytokines. PMID: 21483103
    8. macrophage stabilin-1/CLEVER-1 can potentially regulate leukocyte migration and scavenging during the development of the placenta and fetus PMID: 21480214
    9. Studies identified a binding site on SPARC for stabilin-1 by a solid-state peptide array coupled with a modified enzyme-linked immunosorbent assay. PMID: 21308731
    10. CLEVER-1/stabilin-1 can support lymphocyte transendothelial migration; it also may provide an organ-specific signal for regulatory T cell recruitment to the inflamed liver and to hepatocellular carcinoma. PMID: 21368224
    11. Studies shoe that understanding stabilin-1 behavior in complex biological systems and would open perspectives for therapeutic targeting of stabilin-1 pathways in chronic inflammation. PMID: 20953554
    12. these results indicate that GULP functions as an adaptor protein for stabilin-1-mediated phagocytosis. PMID: 20599701
    13. role in endocytic clearance and secretion in macrophages; review PMID: 19457577
    14. code for homologous transmembrane proteins featuring seven fasciclin-like adhesion domains, 18-20 epidermal-growth-factor domains, one X-link domain and three to six B-(X(7))-B hyaluronan-binding motifs PMID: 11829752
    15. FEEL-1, a novel scavenger receptor with in vitro bacteria-binding and angiogenesis-modulating activities. PMID: 12077138
    16. This and FEEL-2 are endocytic receptors for advanced glycation end products. PMID: 12473645
    17. CLEVER-1 also known as stabilin-1 or FEEL-1) is a large multifunctional glycoprotein implicated in scavenging, angiogenesis, cell adhesion and angiogenesis PMID: 15297319
    18. role for stabilin-1 as a rapidly recycling scavenger receptor PMID: 15345716
    19. stabilin-1 may function in endocytic and secretory processes of human macrophages. PMID: 15345724
    20. Stabilin-1 internalizes and targets secreted protein acidic and rich in cysteine (SPARC) to an endosomal pathway in stably transfected Chinese hamster ovary cells. PMID: 16670288
    21. Stabilin-1 mediates internalization and endosomal sorting of placental lactogen. PMID: 18292525
    22. Stabilin-1, found on alternatively activated macrophages, is a phagocytic receptor mediating the clearance of apoptotic cells in a phosphatidylserine-dependent manner. PMID: 19726632
    23. The novel GGA-binding site EDDADDD is essential for stabilin-1-mediated intracellular sorting but is not required for endocytosis. PMID: 19752197

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  • 亞細(xì)胞定位：
    Membrane; Single-pass type I membrane protein.
  • 組織特異性：
    High levels found in spleen, lymph node, liver and placenta. Also expressed in endothelial cells.
  • 數(shù)據(jù)庫(kù)鏈接：

    HGNC: 18628

    OMIM: 608560

    KEGG: hsa:23166

    STRING: 9606.ENSP00000312946

    UniGene: Hs.301989



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