SOST (resugobart Biosimilar) Recombinant Monoclonal Antibody
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貨號(hào):CSB-RA858415MB1HU
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規(guī)格:¥83486
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其他:
產(chǎn)品詳情
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產(chǎn)品描述:SOST (resugobart Biosimilar Antibody) 重組單克隆抗體重組單克隆抗體其,其別名包括BEER antibody、CDD antibody、Cortical hyperostosis with syndactyly antibody、Sclerosteosis antibody、Sclerostin antibody、Sost antibody、SOST_HUMAN antibody、SOST1 antibody、UNQ2976/PRO7455/PRO7476 antibody和VBCH antibody等。該抗體以重組人SOST蛋白制備而成,具有針對(duì)人類(lèi)SOST蛋白的特異性結(jié)合能力,種屬反應(yīng)性明確為Human,表明其主要與人類(lèi)SOST蛋白發(fā)生免疫反應(yīng)。 resugobart Biosimilar因靶向作用于骨硬化蛋白(Sclerostin)而在臨床上具有應(yīng)用潛力。骨硬化蛋白是一種由SOST基因編碼的糖蛋白,主要由骨細(xì)胞分泌,通過(guò)抑制Wnt信號(hào)通路負(fù)向調(diào)節(jié)骨形成。相關(guān)臨床前及早期臨床研究顯示,該抗體研發(fā)的藥物可特異性阻斷骨硬化蛋白的活性,解除其對(duì)成骨細(xì)胞的抑制作用,從而促進(jìn)骨形成、增加骨密度,為骨質(zhì)疏松癥、骨不連等骨代謝疾病的治療提供了新方向。目前,針對(duì)絕經(jīng)后骨質(zhì)疏松癥、糖皮質(zhì)激素誘導(dǎo)的骨質(zhì)疏松等適應(yīng)癥的臨床試驗(yàn)正在推進(jìn)中,初步結(jié)果顯示其能顯著提升患者骨密度,降低骨折風(fēng)險(xiǎn),且安全性良好。 SOST (resugobart Biosimilar Antibody) 重組單克隆抗體作為特異性工具抗體,被廣泛應(yīng)用于骨生物學(xué)機(jī)制研究。研究者可利用其特異性結(jié)合特性,通過(guò)實(shí)驗(yàn),檢測(cè)SOST蛋白在不同組織、細(xì)胞中的表達(dá)水平及定位,探究其在骨發(fā)育、骨穩(wěn)態(tài)維持及相關(guān)疾病(如骨硬化癥、骨質(zhì)疏松)發(fā)生發(fā)展中的分子機(jī)制。此外,該抗體還可用于構(gòu)建SOST敲除或過(guò)表達(dá)動(dòng)物模型的驗(yàn)證實(shí)驗(yàn),或與其他骨代謝相關(guān)因子(如RANKL、OPG)的相互作用研究,為深入解析骨代謝調(diào)控網(wǎng)絡(luò)提供關(guān)鍵實(shí)驗(yàn)支持。其其的特性也使其在保證與原研抗體功能一致性的同時(shí),為科研工作提供了更經(jīng)濟(jì)、可及的選擇。
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Uniprot No.:
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基因名:
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別名:BEER antibody; CDD antibody; Cortical hyperostosis with syndactyly antibody; Sclerosteosis antibody; Sclerostin antibody; Sost antibody; SOST_HUMAN antibody; SOST1 antibody; UNQ2976/PRO7455/PRO7476 antibody; VBCH antibody
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反應(yīng)種屬:Human
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免疫原:Recombinant Human SOST protein
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免疫原種屬:Homo sapiens (Human)
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標(biāo)記方式:Non-conjugated
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克隆類(lèi)型:Monoclonal
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濃度:It differs from different batches. Please contact us to confirm it.
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保存緩沖液:0.01M PBS,pH7.4
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產(chǎn)品提供形式:Liquid
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應(yīng)用說(shuō)明:Validation Status
Application-specific performance (e.g., in flow cytometry, ELISA, IHC or other assay formats) has not yet been experimentally verified by CUSABIO. Users are advised to determine the optimal working conditions empirically in their own assay systems.
Guaranteed Quality
① Antibody purity?> 95% tested by SDS-PAGE.
② Endotoxin level < 0.1EU/ug tested by LAL method. -
儲(chǔ)存條件:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期:In stock
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用途:It is a non-therapeutic biosimilar antibody, owning the same variable region from the corresponding approved therapeutic antibody. In conclusion, it is a research-grade biosimilar antibody and expressed in mammalian cell, which can be directly used as positive controls in drug discovery or used for rapid verification of the biological functions of target protein.
相關(guān)產(chǎn)品
靶點(diǎn)詳情
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功能:Negative regulator of bone growth that acts through inhibition of Wnt signaling and bone formation.
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基因功能參考文獻(xiàn):
- Sclerostin is degraded by cathepsin K in vitro. Cathepsin K degradation of sclerostin is affected by hypoxia. PMID: 29859187
- Study found that sclerostin concentrations were not significantly higher in patients with bone metastases compared to non-metastatic prostate cancer (PC) but they were significantly higher in patients with CRPC. Sclerostin levels were significantly higher in patients with advanced disease and increased bone turnover due to a compensatory response to the increased number of osteoblasts. PMID: 30116403
- Patients with Latent autoimmune diabetes in Adults (LADA) presented lower bone resorption than did controls, similar to patients with T2 diabetes (T2D). Sclerostin is increased in T2D but not in LADA, suggesting possible roles on bone metabolism in T2D only. PMID: 29506222
- Higher Sclerostin/SOST expression is associated with lower percentage of circulatory blasts and better prognosis in patients with myelofibrosis. PMID: 29532161
- Sclerosteosis is caused by loss-of-function mutations in the SOST gene which encodes a secreted glycoprotein, sclerostin--{REVIEW} PMID: 29080811
- Serum sclerostin level was not an independent predictor of mortality in Maintenance Hemodialysis Patients PMID: 29940587
- these results suggest a possible role of sclerostin in the identification of ankylosing spondylitis patients PMID: 29854850
- important role for SOST SNP rs1877632 and VDR SNPs rs10735810 and rs731236 in the pathophysiology of stress fracture PMID: 29129460
- Sclerostin increased after exercise in comparison to baseline (mean +/- SEM: 410 +/- 27 vs. 290 +/- 19 pg/mL; p < 0.001) corresponding to an increase of +44.3 +/-5.5% PMID: 28374174
- serum sclerostin levels correlated positively with carotid intima-media thickness and inversely with the augmentation index, a marker of arterial stiffness PMID: 28339088
- The difference of serum sclerostin levels in Ankylosing Spondylitis and Rheumatoid Arthritis patients was not significantly different from HC, indicating that the sclerostin may not associate with the development of Ankylosing Spondylitis and Rheumatoid Arthritis. PMID: 28553652
- SOST gene silencing promotes the proliferation, invasion, and migration, and inhibits apoptosis of osteosarcoma cells by activating Wnt/beta-catenin signaling pathway PMID: 28246931
- No difference was found in the serum sclerostin levels between the hyperthyroidism patients and healthy control. PMID: 29059259
- Positivity of RANKL and anti-CCP2 yielded significant risk for progression with negativity for both as reference. No single nucleotide polymorphism encoding TNFSF11 or SOST was associated with increased concentrations of the factors. PMID: 28190118
- Osterix and RUNX2 are transcriptional regulators of sclerostin in human bone PMID: 27154028
- An association was found between rs851054 of the SOST promoter and the fracture rate during childhood osteogenesis imperfecta. PMID: 27519970
- The increased expression of sclerostin in the liver and the association with histologic cholangitis may explain the high serum levels of this protein in patients with primary biliary cirrhosis. PMID: 27019303
- SOST silencing promotes the proliferation, invasion and migration, and decreases the apoptosis of human retinoblastoma cells by activating the Wnt/beta-catenin signaling pathway. PMID: 28485721
- Sclerostin concentrations in serum significantly decreased and IGF-I significantly increased after 12months of resistance training or JUMP. PMID: 27744012
- observed an association between sclerostin levels with fasting insulin levels and homoeostatic model assessment-insulin resistance, but there was no clear association with type 2 diabetes risk. PMID: 28090669
- Sclerostin levels in KTR are normal and influenced more by bone turnover than by eGFR. Its involvement with other hormones of mineral homeostasis (FGF23/Klotho and Vitamin D) is part of the sophisticated cross-talk between bone and the kidney PMID: 28558021
- Vitamin D receptor agonism by paricalcitol causes a moderate increase in serum sclerostin in CKD patients, and this effect is modified by circulating pentosidine levels. PMID: 28017524
- SOST is frequently expressed in skeletal bone- and cartilage-forming tumors. The strong spatial correlation with bone formation and the in vitro expression patterns are in line with the known functions of SOST in nonneoplastic bone, as a feedback inhibitor on osteogenic differentiation. PMID: 27498059
- Intermittent compressive stress regulates Notch receptor and target gene expression via the TGF-beta signaling pathway. Notch signaling participates in TGF-beta-induced sclerostin expression in periodontal ligament cells. PMID: 27966788
- Dickkopf-1 and sclerostin were never correlated with each other or with bone turnover markers patients with Paget's disease of bone. Sclerostin was positively correlated with age. PMID: 28054306
- These data suggest that sclerostin plays an important role in the bone remodeling of tooth movement. PMID: 28081119
- SOST is expressed in the aorta and downregulated in human aortic aneurysms and atherosclerosis, possibly because of epigenetic silencing. PMID: 28062506
- The level of sclerostin was higher in the female obstructive sleep apnea (OSA) patients than that in female controls. Further, in OSA women with cardiovascular comorbidities, sclerostin was higher than in women without such comorbidities. In men, there were no differences in the serum sclerostin level between the OSA and control subjects, nor was there any relationship with cardiovascular diseases. PMID: 26820731
- Knockdown of SOST in MG-63 cells increases osteogenesis and ratio of OPG/RANKL in vitro PMID: 27774939
- The findings confirm that the human SOST gene and sclerostin expression can be considered to be directly 1,25-dihydroxyvitamin D-responsive in osteocytes. PMID: 26690786
- Sclerostin is an osteocyte marker that is strongly expressed in human woven and lamellar bone and mineralizing chondrocytes PMID: 26896083
- similar levels in type 1 diabetes patients and controls; decrease concurrent with adolescent growth spurt PMID: 26094958
- Findings indicate that sclerostin expression is closely associated with the degree of joint damage in primary knee osteoarthritis (OA), confirming its involvement in the development of OA. PMID: 27665782
- Results suggest that sclerostin may have a role in the development of or the response to abdominal aortic calcification in chronic kidney disease. PMID: 27165564
- serum sclerostin levels were lower in nonalcoholic steatohepatitis patients than in controls. PMID: 26056025
- The aim of this study was to evaluate the renal handling of sclerostin. PMID: 27214309
- chronic TNFalpha (tumor necrosis factor alpha)-dependent arthritis, fibroblast-like synoviocytes constitute a major source of sclerostin and that either the lack of sclerostin or its antibody-mediated inhibition leads to an acceleration of rheumatoid arthritis (RA)-like disease. PMID: 27089204
- Sclerostin levels are elevated in CKD patients and are associated with inflammation, vascular lesions, uremia and (potentially) mortality. PMID: 25070604
- Our data also demonstrated that vitamin D deficient newborns exhibited lower sclerostin levels than vitamin D sufficient newborns. PMID: 26352089
- the first evidence suggesting that LRP4 is responsible for the retention of sclerostin in the bone environment in humans. PMID: 26751728
- higher serum sclerostin levels are associated with higher bone mineral density, lower aortic calcification scores, and a better survival rate in hemodialysis patients PMID: 26890570
- findings suggest that serum TGF-beta1 level increases during postmenopause and declines in old age. Sclerostin production is inhibited by TGF-beta1 during early postmenopause PMID: 26826396
- a cell model of human dermal fibroblasts in order to investigate the functions of sclerostin, is reported. PMID: 26851122
- The aims of this study were to evaluate OCN and sclerostin levels in subjects who underwent coronary artery bypass graft (CABG) surgery compared with those in normal controls. PMID: 26576474
- two affected siblings who carried a novel nonsense mutation of SOST in a consanguineous family from China, is reported. PMID: 26283468
- Sclerostin serum levels are not associated with an adverse metabolic profile during pregnancy in women with GDM and PE PMID: 25753744
- Quantitative RT-PCR analysis showed that SOST expression dose-dependently decreased with increasing Wnt signaling, while BMP4 induced SOST expression PMID: 26095393
- The correlation of SOST polymorphisms with changes of BMD and bone biomarkers after treatment was analyzed. PMID: 26250343
- highly sulfated glycosaminoglycans might control bone homeostasis via interference with sclerostin/LRP5/6 complex formation. PMID: 26232882
- Serum sclerostin was associated with serum intact parathyroid hormone in patients undergoing peritoneal dialysis. PMID: 25974190
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相關(guān)疾?。?/div>Sclerosteosis 1 (SOST1); Van Buchem disease (VBCH); Craniodiaphyseal dysplasia autosomal dominant (CDD)亞細(xì)胞定位:Secreted, extracellular space, extracellular matrix.蛋白家族:Sclerostin family組織特異性:Widely expressed at low levels with highest levels in bone, cartilage, kidney, liver, bone marrow and primary osteoblasts differentiated for 21 days. Detected in the subendothelial layer of the aortic intima (at protein level).數(shù)據(jù)庫(kù)鏈接:
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