SOST (Romosozumab-AQQG Biosimilar) Recombinant Monoclonal Antibody
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貨號:CSB-RA858415MB3HU
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規(guī)格:¥83486
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其他:
產(chǎn)品詳情
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產(chǎn)品描述:SOST (Romosozumab-AQQG Biosimilar Antibody)重組單克隆抗體是一種用于科研領(lǐng)域的生物制劑,其核心作用機制是通過特異性結(jié)合并抑制骨硬化蛋白(Sclerostin,SOST蛋白)的活性,進而調(diào)控骨代謝過程。骨硬化蛋白主要由骨細胞分泌,通過抑制Wnt/β-連環(huán)蛋白信號通路負向調(diào)節(jié)成骨細胞活性,而該抗體通過阻斷這一抑制作用,可促進成骨細胞的增殖與分化,同時減少破骨細胞的生成,從而在實驗?zāi)P椭姓宫F(xiàn)出促進骨形成和抑制骨吸收的雙重效應(yīng)。 在科研應(yīng)用中,SOST (Romosozumab-AQQG Biosimilar Antibody)重組單克隆抗體為骨代謝相關(guān)疾病的機制研究提供了重要工具。研究人員可利用該抗體探索骨質(zhì)疏松癥、骨量減少等疾病的病理生理過程,評估其在動物模型中對骨密度、骨微結(jié)構(gòu)及骨強度的影響。此外,該抗體還可用于驗證Wnt信號通路在骨穩(wěn)態(tài)調(diào)節(jié)中的關(guān)鍵作用,或與其他骨代謝調(diào)節(jié)因子聯(lián)合使用,研究協(xié)同干預(yù)策略的可行性。 該制劑的研發(fā)基于重組DNA技術(shù),通過哺乳動物細胞表達系統(tǒng)生產(chǎn),具有高純度和高特異性的特點,確??蒲袑嶒灲Y(jié)果的可靠性與可重復性。其在科研場景中的應(yīng)用,不僅有助于深入理解骨代謝的分子機制,還可為開發(fā)新型骨疾病治療策略提供實驗依據(jù)和理論支持。目前,相關(guān)研究主要集中于骨生物學基礎(chǔ)研究、疾病模型構(gòu)建及潛在治療靶點的驗證等領(lǐng)域。
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Uniprot No.:
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基因名:
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別名:AMG-785 research-grade biosimilar; Anti-sclerostin research-grade biosimilar; Anti-sclerostin monoclonal antibody research-grade biosimilar; CDP-7851 research-grade biosimilar; Evenity research-grade biosimilar; romosozumab research-grade biosimilar; romosozumab research-grade biosimilar; Romosozumab research-grade biosimilar; Romosozumab (Genetical Recombination) research-grade biosimilar; Sclerostin Ab research-grade biosimilar ;SOST antibody; UNQ2976/PRO7455/PRO7476 antibody; Sclerostin antibody
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反應(yīng)種屬:Human
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免疫原:Recombinant Human SOST protein
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免疫原種屬:Homo sapiens (Human)
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標記方式:Non-conjugated
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克隆類型:Monoclonal
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濃度:It differs from different batches. Please contact us to confirm it.
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保存緩沖液:0.01M PBS,pH7.4
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產(chǎn)品提供形式:Liquid
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應(yīng)用說明:Validation Status
Application-specific performance (e.g., in flow cytometry, ELISA, IHC or other assay formats) has not yet been experimentally verified by CUSABIO. Users are advised to determine the optimal working conditions empirically in their own assay systems.
Guaranteed Quality
① Antibody purity?> 95% tested by SDS-PAGE.
② Endotoxin level < 0.1EU/ug tested by LAL method. -
儲存條件:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期:3-4 weeks
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用途:It is a non-therapeutic biosimilar antibody, owning the same variable region from the corresponding approved therapeutic antibody. In conclusion, it is a research-grade biosimilar antibody and expressed in mammalian cell, which can be directly used as positive controls in drug discovery or used for rapid verification of the biological functions of target protein.
相關(guān)產(chǎn)品
靶點詳情
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功能:Negative regulator of bone growth that acts through inhibition of Wnt signaling and bone formation.
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基因功能參考文獻:
- Sclerostin is degraded by cathepsin K in vitro. Cathepsin K degradation of sclerostin is affected by hypoxia. PMID: 29859187
- Study found that sclerostin concentrations were not significantly higher in patients with bone metastases compared to non-metastatic prostate cancer (PC) but they were significantly higher in patients with CRPC. Sclerostin levels were significantly higher in patients with advanced disease and increased bone turnover due to a compensatory response to the increased number of osteoblasts. PMID: 30116403
- Patients with Latent autoimmune diabetes in Adults (LADA) presented lower bone resorption than did controls, similar to patients with T2 diabetes (T2D). Sclerostin is increased in T2D but not in LADA, suggesting possible roles on bone metabolism in T2D only. PMID: 29506222
- Higher Sclerostin/SOST expression is associated with lower percentage of circulatory blasts and better prognosis in patients with myelofibrosis. PMID: 29532161
- Sclerosteosis is caused by loss-of-function mutations in the SOST gene which encodes a secreted glycoprotein, sclerostin--{REVIEW} PMID: 29080811
- Serum sclerostin level was not an independent predictor of mortality in Maintenance Hemodialysis Patients PMID: 29940587
- these results suggest a possible role of sclerostin in the identification of ankylosing spondylitis patients PMID: 29854850
- important role for SOST SNP rs1877632 and VDR SNPs rs10735810 and rs731236 in the pathophysiology of stress fracture PMID: 29129460
- Sclerostin increased after exercise in comparison to baseline (mean +/- SEM: 410 +/- 27 vs. 290 +/- 19 pg/mL; p < 0.001) corresponding to an increase of +44.3 +/-5.5% PMID: 28374174
- serum sclerostin levels correlated positively with carotid intima-media thickness and inversely with the augmentation index, a marker of arterial stiffness PMID: 28339088
- The difference of serum sclerostin levels in Ankylosing Spondylitis and Rheumatoid Arthritis patients was not significantly different from HC, indicating that the sclerostin may not associate with the development of Ankylosing Spondylitis and Rheumatoid Arthritis. PMID: 28553652
- SOST gene silencing promotes the proliferation, invasion, and migration, and inhibits apoptosis of osteosarcoma cells by activating Wnt/beta-catenin signaling pathway PMID: 28246931
- No difference was found in the serum sclerostin levels between the hyperthyroidism patients and healthy control. PMID: 29059259
- Positivity of RANKL and anti-CCP2 yielded significant risk for progression with negativity for both as reference. No single nucleotide polymorphism encoding TNFSF11 or SOST was associated with increased concentrations of the factors. PMID: 28190118
- Osterix and RUNX2 are transcriptional regulators of sclerostin in human bone PMID: 27154028
- An association was found between rs851054 of the SOST promoter and the fracture rate during childhood osteogenesis imperfecta. PMID: 27519970
- The increased expression of sclerostin in the liver and the association with histologic cholangitis may explain the high serum levels of this protein in patients with primary biliary cirrhosis. PMID: 27019303
- SOST silencing promotes the proliferation, invasion and migration, and decreases the apoptosis of human retinoblastoma cells by activating the Wnt/beta-catenin signaling pathway. PMID: 28485721
- Sclerostin concentrations in serum significantly decreased and IGF-I significantly increased after 12months of resistance training or JUMP. PMID: 27744012
- observed an association between sclerostin levels with fasting insulin levels and homoeostatic model assessment-insulin resistance, but there was no clear association with type 2 diabetes risk. PMID: 28090669
- Sclerostin levels in KTR are normal and influenced more by bone turnover than by eGFR. Its involvement with other hormones of mineral homeostasis (FGF23/Klotho and Vitamin D) is part of the sophisticated cross-talk between bone and the kidney PMID: 28558021
- Vitamin D receptor agonism by paricalcitol causes a moderate increase in serum sclerostin in CKD patients, and this effect is modified by circulating pentosidine levels. PMID: 28017524
- SOST is frequently expressed in skeletal bone- and cartilage-forming tumors. The strong spatial correlation with bone formation and the in vitro expression patterns are in line with the known functions of SOST in nonneoplastic bone, as a feedback inhibitor on osteogenic differentiation. PMID: 27498059
- Intermittent compressive stress regulates Notch receptor and target gene expression via the TGF-beta signaling pathway. Notch signaling participates in TGF-beta-induced sclerostin expression in periodontal ligament cells. PMID: 27966788
- Dickkopf-1 and sclerostin were never correlated with each other or with bone turnover markers patients with Paget's disease of bone. Sclerostin was positively correlated with age. PMID: 28054306
- These data suggest that sclerostin plays an important role in the bone remodeling of tooth movement. PMID: 28081119
- SOST is expressed in the aorta and downregulated in human aortic aneurysms and atherosclerosis, possibly because of epigenetic silencing. PMID: 28062506
- The level of sclerostin was higher in the female obstructive sleep apnea (OSA) patients than that in female controls. Further, in OSA women with cardiovascular comorbidities, sclerostin was higher than in women without such comorbidities. In men, there were no differences in the serum sclerostin level between the OSA and control subjects, nor was there any relationship with cardiovascular diseases. PMID: 26820731
- Knockdown of SOST in MG-63 cells increases osteogenesis and ratio of OPG/RANKL in vitro PMID: 27774939
- The findings confirm that the human SOST gene and sclerostin expression can be considered to be directly 1,25-dihydroxyvitamin D-responsive in osteocytes. PMID: 26690786
- Sclerostin is an osteocyte marker that is strongly expressed in human woven and lamellar bone and mineralizing chondrocytes PMID: 26896083
- similar levels in type 1 diabetes patients and controls; decrease concurrent with adolescent growth spurt PMID: 26094958
- Findings indicate that sclerostin expression is closely associated with the degree of joint damage in primary knee osteoarthritis (OA), confirming its involvement in the development of OA. PMID: 27665782
- Results suggest that sclerostin may have a role in the development of or the response to abdominal aortic calcification in chronic kidney disease. PMID: 27165564
- serum sclerostin levels were lower in nonalcoholic steatohepatitis patients than in controls. PMID: 26056025
- The aim of this study was to evaluate the renal handling of sclerostin. PMID: 27214309
- chronic TNFalpha (tumor necrosis factor alpha)-dependent arthritis, fibroblast-like synoviocytes constitute a major source of sclerostin and that either the lack of sclerostin or its antibody-mediated inhibition leads to an acceleration of rheumatoid arthritis (RA)-like disease. PMID: 27089204
- Sclerostin levels are elevated in CKD patients and are associated with inflammation, vascular lesions, uremia and (potentially) mortality. PMID: 25070604
- Our data also demonstrated that vitamin D deficient newborns exhibited lower sclerostin levels than vitamin D sufficient newborns. PMID: 26352089
- the first evidence suggesting that LRP4 is responsible for the retention of sclerostin in the bone environment in humans. PMID: 26751728
- higher serum sclerostin levels are associated with higher bone mineral density, lower aortic calcification scores, and a better survival rate in hemodialysis patients PMID: 26890570
- findings suggest that serum TGF-beta1 level increases during postmenopause and declines in old age. Sclerostin production is inhibited by TGF-beta1 during early postmenopause PMID: 26826396
- a cell model of human dermal fibroblasts in order to investigate the functions of sclerostin, is reported. PMID: 26851122
- The aims of this study were to evaluate OCN and sclerostin levels in subjects who underwent coronary artery bypass graft (CABG) surgery compared with those in normal controls. PMID: 26576474
- two affected siblings who carried a novel nonsense mutation of SOST in a consanguineous family from China, is reported. PMID: 26283468
- Sclerostin serum levels are not associated with an adverse metabolic profile during pregnancy in women with GDM and PE PMID: 25753744
- Quantitative RT-PCR analysis showed that SOST expression dose-dependently decreased with increasing Wnt signaling, while BMP4 induced SOST expression PMID: 26095393
- The correlation of SOST polymorphisms with changes of BMD and bone biomarkers after treatment was analyzed. PMID: 26250343
- highly sulfated glycosaminoglycans might control bone homeostasis via interference with sclerostin/LRP5/6 complex formation. PMID: 26232882
- Serum sclerostin was associated with serum intact parathyroid hormone in patients undergoing peritoneal dialysis. PMID: 25974190
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相關(guān)疾?。?/div>Sclerosteosis 1 (SOST1); Van Buchem disease (VBCH); Craniodiaphyseal dysplasia autosomal dominant (CDD)亞細胞定位:Secreted, extracellular space, extracellular matrix.蛋白家族:Sclerostin family組織特異性:Widely expressed at low levels with highest levels in bone, cartilage, kidney, liver, bone marrow and primary osteoblasts differentiated for 21 days. Detected in the subendothelial layer of the aortic intima (at protein level).數(shù)據(jù)庫鏈接:
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