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  4. SLAMF7 (Elotuzumab Biosimilar) Recombinant Monoclonal Antibody

SLAMF7 (Elotuzumab Biosimilar) Recombinant Monoclonal Antibody

  • 貨號(hào)：
    CSB-RA021369MB1HU
  • 規(guī)格：
    ￥83486
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品描述：
    SLAMF7(Elotuzumab Biosimilar Antibody)重組單克隆抗體是一種針對(duì)SLAMF7靶點(diǎn)的重組單克隆抗體，主要應(yīng)用于生命科學(xué)研究領(lǐng)域。SLAMF7（信號(hào)淋巴細(xì)胞激活分子家族成員7）是一種表達(dá)于多種免疫細(xì)胞表面的跨膜糖蛋白，在免疫調(diào)節(jié)、細(xì)胞信號(hào)轉(zhuǎn)導(dǎo)等生物學(xué)過(guò)程中發(fā)揮重要作用。該抗體通過(guò)特異性識(shí)別并結(jié)合SLAMF7分子，為研究其在生理及病理狀態(tài)下的功能提供了有力工具。 在科研應(yīng)用中，SLAMF7重組單克隆抗體可用于某些實(shí)驗(yàn)，助力研究者深入探索SLAMF7在造血系統(tǒng)疾病、自身免疫性疾病及腫瘤微環(huán)境中的作用機(jī)制。其高特異性和親和力確保了實(shí)驗(yàn)結(jié)果的準(zhǔn)確性與可靠性，為相關(guān)領(lǐng)域的基礎(chǔ)研究和藥物開(kāi)發(fā)前期探索提供支持。 該抗體采用重組DNA技術(shù)在哺乳動(dòng)物細(xì)胞中表達(dá)，經(jīng)過(guò)嚴(yán)格的純化和質(zhì)量控制流程，保證了產(chǎn)品的高純度和批次間一致性。作為科研用試劑，它為揭示SLAMF7介導(dǎo)的信號(hào)通路、細(xì)胞間相互作用及疾病發(fā)生發(fā)展機(jī)制提供了關(guān)鍵實(shí)驗(yàn)材料，推動(dòng)免疫學(xué)、腫瘤學(xué)等領(lǐng)域的研究進(jìn)展。
  • Uniprot No.：
  • 基因名：
  • 別名：
    BMS-901608 research-grade biosimilar; elotuzumab research-grade biosimilar; Elotuzumab (genetical recombination) (JAN) research-grade biosimilar; Elotuzumab (USAN) research-grade biosimilar; Elotuzumab Genetical Recombination research-grade biosimilar; Empliciti research-grade biosimilar; HuLuc63 research-grade biosimilar; HULUC-63 research-grade biosimilar; Immunoglobulin G1, anti-(human protein CS1) (human-mouse HuLuc63 heavy chain), disulfide with human-mouse HuLuc63 kappa-chain, dimer research-grade biosimilar; PDL063 research-grade biosimilar; PDL-063 research-grade biosimilar ;SLAMF7 antibody; CS1 antibody; UNQ576/PRO1138 antibody; SLAM family member 7 antibody; CD2 subset 1 antibody; CD2-like receptor-activating cytotoxic cells antibody; CRACC antibody; Membrane protein FOAP-12 antibody; Novel Ly9 antibody; Protein 19A antibody; CD antigen CD319 antibody
  • 反應(yīng)種屬：
    Human
  • 免疫原：
    Recombinant Human SLAMF7 protein
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標(biāo)記方式：
    Non-conjugated
  • 克隆類(lèi)型：
    Monoclonal
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    0.01M PBS，pH7.4
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用說(shuō)明：
    Validation Status
    Application-specific performance (e.g., in flow cytometry, ELISA, IHC or other assay formats) has not yet been experimentally verified by CUSABIO. Users are advised to determine the optimal working conditions empirically in their own assay systems.
    Guaranteed Quality
    ① Antibody purity?> 95% tested by SDS-PAGE.
    ② Endotoxin level < 0.1EU/ug tested by LAL method.
  • 儲(chǔ)存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    3-4 weeks
  • 用途：
    It is a non-therapeutic biosimilar antibody, owning the same variable region from the corresponding approved therapeutic antibody. In conclusion, it is a research-grade biosimilar antibody and expressed in mammalian cell, which can be directly used as positive controls in drug discovery or used for rapid verification of the biological functions of target protein.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能：
    Self-ligand receptor of the signaling lymphocytic activation molecule (SLAM) family. SLAM receptors triggered by homo- or heterotypic cell-cell interactions are modulating the activation and differentiation of a wide variety of immune cells and thus are involved in the regulation and interconnection of both innate and adaptive immune response. Activities are controlled by presence or absence of small cytoplasmic adapter proteins, SH2D1A/SAP and/or SH2D1B/EAT-2. Isoform 1 mediates NK cell activation through a SH2D1A-independent extracellular signal-regulated ERK-mediated pathway. Positively regulates NK cell functions by a mechanism dependent on phosphorylated SH2D1B. Downstream signaling implicates PLCG1, PLCG2 and PI3K. In addition to heterotypic NK cells-target cells interactions also homotypic interactions between NK cells may contribute to activation. However, in the absence of SH2D1B, inhibits NK cell function. Acts also inhibitory in T-cells. May play a role in lymphocyte adhesion. In LPS-activated monocytes negatively regulates production of proinflammatory cytokines.; Isoform 3 does not mediate any NK cell activation.
  • 基因功能參考文獻(xiàn)：
    1. Memory CD8+ T cells from SLE patients displayed decreased amounts of SLAMF7, a surface receptor that characterizes effector CD8+ T cells. Ligation of SLAMF7 increased CD8+ T cell degranulation capacity and the percentage of IFNgamma-producing cells in response to antigen challenge in SLE patients and healthy controls. SLAMF7 engagement promoted cytotoxic lysis of target cells in response to stimulation with viral antig... PMID: 28076903
    2. phagocytosis of haematopoietic tumour cells during SIRPalpha-CD47 blockade was strictly dependent on SLAM family receptors in vitro and in vivo; in both mouse and human cells, this function required a single SLAM family member, SLAMF7 (also known as CRACC, CS1, CD319), expressed on macrophages and tumour cell targets PMID: 28424516
    3. Cohort statistics revealed a significant increase of circulating sSLAMF7 in multiple myeloma patients versus normal controls PMID: 27116021
    4. Blimp-1 regulates the transcription of CS1 gene in NK and B cell lines from multiple myeloma and diffuse large B cell lymphoma patients. PMID: 26310579
    5. SLAMF7-triggered inhibition is mediated by a mechanism involving Src kinases, CD45, and SHIP-1 that is defective in MM cells PMID: 25312647
    6. Our data highlight the therapeutic potential of targeting CD319 in rheumatoid arthritis PMID: 24299175
    7. SLAMF7 plays an inhibitory role in human monocytes to control proinflammatory immune responses. PMID: 23695528
    8. These results suggest a role for CD319 and CD229 in the systemic lupus erythematosus disease process. PMID: 23956418
    9. These data suggest an involvement of CRACC-mediated NK cell activation in periodontal tissue destruction and point to a plausible distinction in the pathobiology of aggressive and chronic periodontitis. PMID: 23250953
    10. CS1-L and CS1-S may differentially regulate human NK cell functions PMID: 15368295
    11. CS1 may play a role in the regulation of B lymphocyte proliferation during immune responses PMID: 17878365
    12. CS1 was expressed at adhesion-promoting uropod membranes of polarized Multiple Myeloma cells, andis required for MM cell adhesion to bone marrow stromal cells PMID: 17906076
    13. HuLuc63 eliminates myeloma cells, at least in part, via NK-mediated ADCC and shows the therapeutic potential of targeting CS1 with HuLuc63 for the treatment of multiple myeloma. PMID: 18451245

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  • 亞細(xì)胞定位：
    Membrane; Single-pass type I membrane protein.
  • 組織特異性：
    Expressed in spleen, lymph node, peripheral blood leukocytes, bone marrow, small intestine, stomach, appendix, lung and trachea. Expression was detected in NK cells, activated B-cells, NK-cell line but not in promyelocytic, B-, or T-cell lines. Expressed
  • 數(shù)據(jù)庫(kù)鏈接：

    HGNC: 21394

    OMIM: 606625

    KEGG: hsa:57823

    STRING: 9606.ENSP00000357022

    UniGene: Hs.517265



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