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  4. SIGLEC9 (CN 111465614 A Biosimilar) Recombinant Monoclonal Antibody

SIGLEC9 (CN 111465614 A Biosimilar) Recombinant Monoclonal Antibody

  • 貨號(hào)：
    CSB-RA021303MB1HU
  • 規(guī)格：
    ￥83486
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品描述：
    SIGLEC9重組單克隆抗體（專利號(hào)CN 111465614 A）是一種靶向Siglec-9蛋白的生物制劑，其別名為CD329抗體、CDw329抗體、FOAP-9抗體、OBBP LIKE抗體、SIGLEC9抗體等，對(duì)應(yīng)靶點(diǎn)為唾液酸結(jié)合免疫球蛋白樣凝集素9（Sialic acid-binding Ig-like lectin 9），屬于免疫球蛋白超家族成員。該抗體以重組人SIGLEC9蛋白制備，具有高度的種屬反應(yīng)性，主要針對(duì)人源Siglec-9蛋白發(fā)揮特異性結(jié)合作用。 針對(duì)Siglec-9蛋白的相關(guān)藥物可通過(guò)阻斷其與配體的相互作用，解除免疫抑制，增強(qiáng)中性粒細(xì)胞對(duì)病原體的清除能力，有望用于膿毒癥、類風(fēng)濕關(guān)節(jié)炎等炎癥性疾病的治療；同時(shí)，在腫瘤治療方面，相關(guān)藥物可能通過(guò)干擾Siglec-9在腫瘤微環(huán)境中與腫瘤細(xì)胞表面唾液酸聚糖的結(jié)合，阻斷免疫逃逸，激活抗腫瘤免疫應(yīng)答，成為實(shí)體瘤或血液瘤治療的新策略。 SIGLEC9重組單克隆抗體是探究Siglec-9生物學(xué)功能的關(guān)鍵工具。其可用于檢測(cè)免疫細(xì)胞表面Siglec-9的表達(dá)水平，分析組織樣本中的蛋白定位，以及免疫沉淀-質(zhì)譜聯(lián)用研究Siglec-9的相互作用蛋白。此外，該抗體可通過(guò)體外中和實(shí)驗(yàn)或構(gòu)建動(dòng)物模型，揭示Siglec-9在免疫穩(wěn)態(tài)維持、炎癥反應(yīng)調(diào)控及腫瘤發(fā)生發(fā)展中的分子機(jī)制，為深入理解免疫檢查點(diǎn)分子的作用網(wǎng)絡(luò)提供實(shí)驗(yàn)支持。目前，其在免疫代謝、自身免疫病發(fā)病機(jī)制等基礎(chǔ)研究中已有廣泛應(yīng)用，推動(dòng)了Siglec家族相關(guān)信號(hào)通路的研究進(jìn)展。
  • Uniprot No.：
  • 基因名：
  • 別名：
    CD329 antibody; CDw329 antibody; FOAP 9 antibody; OB binding protein like antibody; OBBP LIKE antibody; Protein FOAP 9 antibody; Protein FOAP-9 antibody; sialic acid binding Ig like lectin 9 antibody; Sialic acid-binding Ig-like lectin 9 antibody; Sialic acid-binding immunoglobulin like lectin 9 antibody; SIGL9_HUMAN antibody; Siglec 9 antibody; Siglec-9 antibody; SIGLEC9 antibody
  • 反應(yīng)種屬：
    Human
  • 免疫原：
    Recombinant Human SIGLEC9 protein
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標(biāo)記方式：
    Non-conjugated
  • 克隆類型：
    Monoclonal
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    0.01M PBS，pH7.4
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用說(shuō)明：
    Validation Status
    Application-specific performance (e.g., in flow cytometry, ELISA, IHC or other assay formats) has not yet been experimentally verified by CUSABIO. Users are advised to determine the optimal working conditions empirically in their own assay systems.
    Guaranteed Quality
    ① Antibody purity?> 95% tested by SDS-PAGE.
    ② Endotoxin level < 0.1EU/ug tested by LAL method.
  • 儲(chǔ)存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    In stock
  • 用途：
    It is a non-therapeutic biosimilar antibody, owning the same variable region from the corresponding approved therapeutic antibody. In conclusion, it is a research-grade biosimilar antibody and expressed in mammalian cell, which can be directly used as positive controls in drug discovery or used for rapid verification of the biological functions of target protein.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能：
    Putative adhesion molecule that mediates sialic-acid dependent binding to cells. Preferentially binds to alpha-2,3- or alpha-2,6-linked sialic acid. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface.
  • 基因功能參考文獻(xiàn)：
    1. The SIGLEC9 rs2075803 G/rs2258983 A haplotype, which corresponds to a Siglec-9 variant that is less effective at suppressing inflammatory response, may be a risk factor for the development of emphysema. PMID: 27878892
    2. Glycophorin A, the most abundant sialoglycoprotein on erythrocytes, engaged neutrophil Siglec-9, a sialic acid-recognizing receptor known to dampen innate immune cell activation. These studies demonstrate a previously unsuspected role for erythrocytes in suppressing neutrophils ex vivo and in vitro and help explain why neutrophils become easily activated after separation from whole blood. PMID: 28416510
    3. Data suggest that sialic acid-binding Ig-like lectin-9 (Siglec-9)may serve as a potential diagnostic and therapeutic target for rheumatoid arthritis (RA). PMID: 28273363
    4. The mechanism of the Siglec-9 and AOC3 interaction is mediated both by protein-sugar interactions via the V domain and by the protein-protein interactions via the C22 Siglec9 domain. PMID: 27893774
    5. This work defines a critical role for aberrantly glycosylated MUC1 and identifies an activating pathway that follows engagement of Siglec-9. PMID: 27595232
    6. Constitutively expressed Siglec-9 inhibits LPS-induced CCR7, but enhances IL-4-induced CD200R expression in human macrophages. PMID: 26923638
    7. Ligands for Siglec-8 and Siglec-9 may regulate the function of eosinophils, mast cells, neutrophils, and other cells in sinus mucosa. PMID: 26694037
    8. Inflammation results in up-regulation of immuneinhibitory Siglec-8 and Siglec-9 sialoglycan ligands on human airways. PMID: 25747723
    9. a polymorphism that reduced Siglec-9 binding to carcinomas was associated with improved early survival in non-small-cell lung cancer patients PMID: 25225409
    10. Dasatinib enhances migration of monocyte-derived dendritic cells by reducing phosphorylation of inhibitory immune receptors Siglec-9 and Siglec-3. PMID: 24882272
    11. Protein degradation of focal adhesion kinase and related molecules was induced by Siglec-9 binding to its counterreceptors via sialylglycoconjugates, leading to the modulation of adhesion kinetics of cancer cells. PMID: 24145038
    12. Siglec-9 expressed on immune cells may play a role as a potential counterreceptor for MUC1 and that this signaling may be another MUC1-mediated pathway and function in parallel with a growth factor-dependent pathway. PMID: 24045940
    13. The Siglec-9 peptide binding to the enzymatic groove of VAP-1 can be used for imaging conditions, such as inflammation and cancer. PMID: 21821708
    14. Siglec-9 A391C was the only polymorphism related to TCR-mediated signaling in human Siglec-9, resulting in less inhibition compared to the wild type. PMID: 20733319
    15. These results suggest that Siglec-9 expressed on DCs is involved in immunoregulation through ligation with mucins in an epithelial cancer patient. PMID: 20971061
    16. MUC16-Siglec-9 binding likely mediates inhibition of anti-tumor immune responses. PMID: 20497550
    17. Septic shock patients exhibit different ex vivo death responses of blood neutrophils after Siglec-9 ligation early in shock. PMID: 19295491
    18. Binding studies on recombinant human Siglec-9 show recognition of both Neu5Ac and Neu5Gc; in striking contrast, chimpanzee and gorilla Siglec-9 strongly prefer binding Neu5Gc. PMID: 14693915
    19. Siglec-9 can inhibit Fc epsilon receptor I-mediated serotonin release from rat basophilic leukemia cells and recruit the tyrosine phosphatases SHP-1 and SHP-2. PMID: 15557178
    20. data suggest that apoptotic (ROS- and caspase-dependent) and nonapoptotic (ROS-dependent) death pathways are initiated in neutrophils via Siglec-9 PMID: 15827126
    21. Siglecs-9 did not interact with sulfate derivatives of LacNAc and sulfated oligosaccharides containing sialic acid. PMID: 16732727
    22. The Siglec-9 provides not only a useful marker for certain subsets of AML, but also a potential therapeutic target. PMID: 16828866
    23. These results demonstrate that Siglec-9 enhances the production of the anti-inflammatory cytokine IL-10 in macrophages. PMID: 18325328
    24. A review of the cytotoxic effects of natural anti-Siglec9 autoantibodies on both neutrophils and eosinophils. PMID: 18558361
    25. Increased bacterial survival are also facilitated by group b Streptococcus sialylated capsular polysaccharide interactions with Siglec-9. PMID: 19196661
    26. Data suggest that age-specific interactions between Siglec-9 and SHP-1 may influence the altered inflammatory responsiveness and longevity of neonatal polymorphonuclear neutrophils. PMID: 19542910

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  • 亞細(xì)胞定位：
    Membrane; Single-pass type I membrane protein.
  • 蛋白家族：
    Immunoglobulin superfamily, SIGLEC (sialic acid binding Ig-like lectin) family
  • 組織特異性：
    Expressed by peripheral blood leukocytes (neutrophils and monocytes but not eosinophils). Found in liver, fetal liver, bone marrow, placenta, spleen and in lower levels in skeletal muscle, fetal brain, stomach, lung, thymus, prostate, brain, mammary, adre
  • 數(shù)據(jù)庫(kù)鏈接：

    HGNC: 10878

    OMIM: 605640

    KEGG: hsa:27180

    STRING: 9606.ENSP00000413861

    UniGene: Hs.245828



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