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  4. SIGLEC8 (lirentelimab Biosimilar) Recombinant Monoclonal Antibody

SIGLEC8 (lirentelimab Biosimilar) Recombinant Monoclonal Antibody

  • 貨號(hào)：
    CSB-RA878931MB1HU
  • 規(guī)格：
    ￥83486
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品描述：
    SIGLEC8（lirentelimab Biosimilar Antibody）重組單克隆抗體是一種針對(duì)人類唾液酸結(jié)合免疫球蛋白樣凝集素8（SIGLEC8）。SIGLEC8，又稱CD329、CDw329、SAF 2、SAF-2、SAF2、唾液酸結(jié)合Ig樣凝集素8、唾液黏附素家族成員2、SIGL8_HUMAN、Siglec 8、Siglec-8、SIGLEC8或SIGLEC8L，是一種表達(dá)于嗜酸性粒細(xì)胞、肥大細(xì)胞等免疫細(xì)胞表面的跨膜蛋白，在 allergic炎癥和免疫調(diào)節(jié)中發(fā)揮關(guān)鍵作用。該抗體以重組人SIGLEC8蛋白制備，具有高度的種屬反應(yīng)性，僅特異性識(shí)別人源SIGLEC8分子。 lirentelimab因其對(duì)嗜酸性粒細(xì)胞和肥大細(xì)胞的靶向調(diào)節(jié)作用，成為 allergic疾?。ㄈ缦?、特應(yīng)性皮炎）和嗜酸性粒細(xì)胞增多綜合征等疾病的潛在治療藥物。通過與SIGLEC8結(jié)合，該抗體研發(fā)的藥物可誘導(dǎo)嗜酸性粒細(xì)胞凋亡、抑制肥大細(xì)胞活化，從而減輕炎癥反應(yīng)和組織損傷。目前，lirentelimab已進(jìn)入多項(xiàng)臨床試驗(yàn)，驗(yàn)證其在重度 asthma、慢性自發(fā)性蕁麻疹等疾病中的療效與安全性，為 allergic疾病的精準(zhǔn)治療提供新方向。 SIGLEC8重組單克隆抗體是研究免疫細(xì)胞功能和相關(guān)疾病機(jī)制的重要工具。它可用于檢測(cè)SIGLEC8的表達(dá)水平，或分析其在組織中的定位，以及體外細(xì)胞實(shí)驗(yàn)中調(diào)控嗜酸性粒細(xì)胞和肥大細(xì)胞的活性。此外，該抗體還可助力探索SIGLEC8在免疫穩(wěn)態(tài)、腫瘤微環(huán)境調(diào)節(jié)等領(lǐng)域的潛在作用，為開發(fā)新的免疫治療策略提供實(shí)驗(yàn)基礎(chǔ)。其高度的特異性和人源反應(yīng)性，確保了實(shí)驗(yàn)結(jié)果的可靠性和臨床轉(zhuǎn)化價(jià)值。
  • Uniprot No.：
  • 基因名：
  • 別名：
    CD329 antigen antibody; CDw329 antibody; SAF 2 antibody; SAF-2 antibody; SAF2 antibody; Sialic acid binding Ig like lectin 8 antibody; Sialic acid-binding Ig-like lectin 8 antibody; Sialoadhesin family member 2 antibody; SIGL8_HUMAN antibody; Siglec 8 antibody; Siglec-8 antibody; SIGLEC8 antibody; SIGLEC8L antibody
  • 反應(yīng)種屬：
    Human
  • 免疫原：
    Recombinant Human SIGLEC8 protein
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標(biāo)記方式：
    Non-conjugated
  • 克隆類型：
    Monoclonal
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    0.01M PBS，pH7.4
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用說明：
    Validation Status
    Application-specific performance (e.g., in flow cytometry, ELISA, IHC or other assay formats) has not yet been experimentally verified by CUSABIO. Users are advised to determine the optimal working conditions empirically in their own assay systems.
    Guaranteed Quality
    ① Antibody purity?> 95% tested by SDS-PAGE.
    ② Endotoxin level < 0.1EU/ug tested by LAL method.
  • 儲(chǔ)存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    In stock
  • 用途：
    It is a non-therapeutic biosimilar antibody, owning the same variable region from the corresponding approved therapeutic antibody. In conclusion, it is a research-grade biosimilar antibody and expressed in mammalian cell, which can be directly used as positive controls in drug discovery or used for rapid verification of the biological functions of target protein.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能：
    Putative adhesion molecule that mediates sialic-acid dependent binding to red blood cells. Preferentially binds to alpha-2,3-linked sialic acid. Also binds to alpha-2,6-linked sialic acid. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface. Recognizes simultaneously epitopes having a terminal N-acetylneuraminic acid (sialic acid) and an underlying 6-O-sulfated galactose. Preferentially binds to Gal-6-sulfated sialyl-Lewis X glycan epitopes.
  • 基因功能參考文獻(xiàn)：
    1. In differentiating ,eosinophils, SIGLEC-8 messenger RNA and protein were markedly down-regulated in parallel with OLIG2 by an OLIG2 small interfering RNA or a short hairpin RNA. An E-box in the first intron was found to stimulate SIGLEC-8 gene transcription and to bind OLIG2. PMID: 27154355
    2. miR-215 acts in concert with the host gene IARS2 to affect neuron migration and proliferation through the target gene SIGLEC-8. PMID: 28006787
    3. Our study suggested that intratumoral Siglec-8 expression was an independent prognostic factor for overall survival of patients with gastric cancer PMID: 26883254
    4. Siglec-8 expression is sensitive to tiotropium and formoterol, indicating that it may be involved in COPD pathogenesis and may influence COPD phenotyping PMID: 23835953
    5. In activated eosinophils ligation of Siglec-8 leads to ROS-dependent enhancement of IL-5-induced ERK phosphorylation, which results in a novel mode of biochemically regulated eosinophil cell death. PMID: 23684072
    6. Engagement of Siglec-8 on blood eosinophils results in caspase- and mitochondria-dependent apoptosis. PMID: 22324980
    7. Report the development of a sensitive competitive ELISA to detect sSiglec-8 in human serum samples obtained from patients with various forms of eosinophilia. PMID: 22683541
    8. Eosinophils primed by IL-33 and/or IL-5 in vivo would be expected to display enhanced susceptibility to undergoing Siglec-8-induced apoptosis. PMID: 22079334
    9. expressed on eosinophils and basophils from subjects with chronic eosinophilic leukemia, chronic myelogenous leukemia, and on malignant and non-malignant bone marrow mast cells PMID: 21938510
    10. The Siglec-8 gene may be a susceptibility locus for asthma. PMID: 20087405
    11. Sialic acid binding immunoglobulin-like lectin 8 (Siglec-8) cross-linking with antibodies rapidly generated caspase-3-like activity and reduced eosinophil viability through induction of apoptosis PMID: 12609831
    12. Siglec-8 binds preferentially to a sLex structure bearing an additional sulfate ester on the galactose 6-hydroxyl PMID: 15563466
    13. Siglec-8-induced apoptosis in eosinophils occurs through the sequential production of reactive oxygen species, followed by induction of mitochondrial injury and caspase cleavage. PMID: 16157303
    14. IL-5 priming enhances Siglec-8-mediated mitochondrial and ROS-dependent eosinophil apoptosis and eliminates caspase dependence. PMID: 17690326
    15. First reported inhibitory effects of Siglec engagement on human mast cells. PMID: 18036650
    16. A review of the cytotoxic effects of natural anti-Siglec8 autoantibodies on both neutrophils and eosinophils. PMID: 18558361
    17. REVIEW: Siglec-8 and Siglec-F function on human eosinophils, and Siglec-8 function on mast cells PMID: 19178537
    18. Selective and specific engagement and binding of Siglec-8 on eosinophils by a synthetic 6'-sulfo-sLe(x)-containing ligand could be useful for controlling eosinophilic inflammatory responses in vivo. PMID: 19458105

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  • 亞細(xì)胞定位：
    Membrane; Single-pass type I membrane protein.
  • 蛋白家族：
    Immunoglobulin superfamily, SIGLEC (sialic acid binding Ig-like lectin) family
  • 組織特異性：
    Expressed specifically on red blood cells namely basophil, mast cells and eosinophils.
  • 數(shù)據(jù)庫鏈接：

    HGNC: 10877

    OMIM: 605639

    KEGG: hsa:27181

    STRING: 9606.ENSP00000321077

    UniGene: Hs.447899



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