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  4. SIGLEC8 (Antolimab Biosimilar) Recombinant Monoclonal Antibody

SIGLEC8 (Antolimab Biosimilar) Recombinant Monoclonal Antibody

  • 貨號(hào)：
    CSB-RA878931MB2HU
  • 規(guī)格：
    ￥83486
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品描述：
    SIGLEC8(Antolimab Biosimilar Antibody)重組單克隆抗體是一種針對(duì)SIGLEC8靶點(diǎn)的科研用生物試劑。SIGLEC8是唾液酸結(jié)合免疫球蛋白樣凝集素家族成員，主要在嗜酸性粒細(xì)胞、肥大細(xì)胞等免疫細(xì)胞表面表達(dá)，參與調(diào)控過(guò)敏反應(yīng)、炎癥反應(yīng)及細(xì)胞凋亡等生理病理過(guò)程。 該抗體通過(guò)基因工程技術(shù)制備，具有高特異性和親和力，能特異性識(shí)別并結(jié)合SIGLEC8分子，為相關(guān)機(jī)制研究提供有力工具。在科研應(yīng)用中，可用于檢測(cè)細(xì)胞表面SIGLEC8的表達(dá)水平，觀察其亞細(xì)胞定位，以及實(shí)驗(yàn)分析蛋白質(zhì)相互作用等。 通過(guò)阻斷或激活SIGLEC8信號(hào)通路，研究人員可深入探索該分子在哮喘、過(guò)敏性鼻炎、特應(yīng)性皮炎等過(guò)敏性疾病中的作用機(jī)制，為開(kāi)發(fā)新型治療策略提供理論依據(jù)。此外，該抗體也可用于構(gòu)建SIGLEC8相關(guān)的細(xì)胞模型和動(dòng)物模型，助力免疫調(diào)節(jié)機(jī)制的基礎(chǔ)研究。 產(chǎn)品嚴(yán)格按照科研試劑標(biāo)準(zhǔn)生產(chǎn)，經(jīng)過(guò)多項(xiàng)質(zhì)量控制檢測(cè)，確保批次間穩(wěn)定性和實(shí)驗(yàn)結(jié)果的可靠性。適用于免疫學(xué)、細(xì)胞生物學(xué)、分子生物學(xué)等領(lǐng)域的基礎(chǔ)研究和藥物研發(fā)前期探索，為揭示SIGLEC8介導(dǎo)的免疫調(diào)控網(wǎng)絡(luò)提供重要支持。
  • Uniprot No.：
  • 基因名：
  • 別名：
    AK 002 research-grade biosimilar; AK-002 research-grade biosimilar; Lirentelimab research-grade biosimilar ;SIGLEC8 antibody; SAF2 antibody; Sialic acid-binding Ig-like lectin 8 antibody; Siglec-8 antibody; Sialoadhesin family member 2 antibody; SAF-2 antibody
  • 反應(yīng)種屬：
    Human
  • 免疫原：
    Recombinant Human SIGLEC8 protein
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標(biāo)記方式：
    Non-conjugated
  • 克隆類(lèi)型：
    Monoclonal
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    0.01M PBS，pH7.4
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用說(shuō)明：
    Validation Status
    Application-specific performance (e.g., in flow cytometry, ELISA, IHC or other assay formats) has not yet been experimentally verified by CUSABIO. Users are advised to determine the optimal working conditions empirically in their own assay systems.
    Guaranteed Quality
    ① Antibody purity?> 95% tested by SDS-PAGE.
    ② Endotoxin level < 0.1EU/ug tested by LAL method.
  • 儲(chǔ)存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    3-4 weeks
  • 用途：
    It is a non-therapeutic biosimilar antibody, owning the same variable region from the corresponding approved therapeutic antibody. In conclusion, it is a research-grade biosimilar antibody and expressed in mammalian cell, which can be directly used as positive controls in drug discovery or used for rapid verification of the biological functions of target protein.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能：
    Putative adhesion molecule that mediates sialic-acid dependent binding to red blood cells. Preferentially binds to alpha-2,3-linked sialic acid. Also binds to alpha-2,6-linked sialic acid. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface. Recognizes simultaneously epitopes having a terminal N-acetylneuraminic acid (sialic acid) and an underlying 6-O-sulfated galactose. Preferentially binds to Gal-6-sulfated sialyl-Lewis X glycan epitopes.
  • 基因功能參考文獻(xiàn)：
    1. In differentiating ,eosinophils, SIGLEC-8 messenger RNA and protein were markedly down-regulated in parallel with OLIG2 by an OLIG2 small interfering RNA or a short hairpin RNA. An E-box in the first intron was found to stimulate SIGLEC-8 gene transcription and to bind OLIG2. PMID: 27154355
    2. miR-215 acts in concert with the host gene IARS2 to affect neuron migration and proliferation through the target gene SIGLEC-8. PMID: 28006787
    3. Our study suggested that intratumoral Siglec-8 expression was an independent prognostic factor for overall survival of patients with gastric cancer PMID: 26883254
    4. Siglec-8 expression is sensitive to tiotropium and formoterol, indicating that it may be involved in COPD pathogenesis and may influence COPD phenotyping PMID: 23835953
    5. In activated eosinophils ligation of Siglec-8 leads to ROS-dependent enhancement of IL-5-induced ERK phosphorylation, which results in a novel mode of biochemically regulated eosinophil cell death. PMID: 23684072
    6. Engagement of Siglec-8 on blood eosinophils results in caspase- and mitochondria-dependent apoptosis. PMID: 22324980
    7. Report the development of a sensitive competitive ELISA to detect sSiglec-8 in human serum samples obtained from patients with various forms of eosinophilia. PMID: 22683541
    8. Eosinophils primed by IL-33 and/or IL-5 in vivo would be expected to display enhanced susceptibility to undergoing Siglec-8-induced apoptosis. PMID: 22079334
    9. expressed on eosinophils and basophils from subjects with chronic eosinophilic leukemia, chronic myelogenous leukemia, and on malignant and non-malignant bone marrow mast cells PMID: 21938510
    10. The Siglec-8 gene may be a susceptibility locus for asthma. PMID: 20087405
    11. Sialic acid binding immunoglobulin-like lectin 8 (Siglec-8) cross-linking with antibodies rapidly generated caspase-3-like activity and reduced eosinophil viability through induction of apoptosis PMID: 12609831
    12. Siglec-8 binds preferentially to a sLex structure bearing an additional sulfate ester on the galactose 6-hydroxyl PMID: 15563466
    13. Siglec-8-induced apoptosis in eosinophils occurs through the sequential production of reactive oxygen species, followed by induction of mitochondrial injury and caspase cleavage. PMID: 16157303
    14. IL-5 priming enhances Siglec-8-mediated mitochondrial and ROS-dependent eosinophil apoptosis and eliminates caspase dependence. PMID: 17690326
    15. First reported inhibitory effects of Siglec engagement on human mast cells. PMID: 18036650
    16. A review of the cytotoxic effects of natural anti-Siglec8 autoantibodies on both neutrophils and eosinophils. PMID: 18558361
    17. REVIEW: Siglec-8 and Siglec-F function on human eosinophils, and Siglec-8 function on mast cells PMID: 19178537
    18. Selective and specific engagement and binding of Siglec-8 on eosinophils by a synthetic 6'-sulfo-sLe(x)-containing ligand could be useful for controlling eosinophilic inflammatory responses in vivo. PMID: 19458105

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  • 亞細(xì)胞定位：
    Membrane; Single-pass type I membrane protein.
  • 蛋白家族：
    Immunoglobulin superfamily, SIGLEC (sialic acid binding Ig-like lectin) family
  • 組織特異性：
    Expressed specifically on red blood cells namely basophil, mast cells and eosinophils.
  • 數(shù)據(jù)庫(kù)鏈接：

    HGNC: 10877

    OMIM: 605639

    KEGG: hsa:27181

    STRING: 9606.ENSP00000321077

    UniGene: Hs.447899



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