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  4. SIGLEC6 (AK-006 Biosimilar) Recombinant Monoclonal Antibody

SIGLEC6 (AK-006 Biosimilar) Recombinant Monoclonal Antibody

  • 貨號(hào)：
    CSB-RA021300MB1HU
  • 規(guī)格：
    ￥83486
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品描述：
    SIGLEC6 (AK-006 Biosimilar Antibody)重組單克隆抗體是一款專為生命科學(xué)研究設(shè)計(jì)的高精度實(shí)驗(yàn)工具。該抗體以SIGLEC6蛋白為靶向目標(biāo)，通過重組DNA技術(shù)在哺乳動(dòng)物細(xì)胞中表達(dá)制備，具有高特異性和高親和力的特性。 SIGLEC6屬于唾液酸結(jié)合免疫球蛋白樣凝集素家族成員，在多種生理和病理過程中發(fā)揮關(guān)鍵調(diào)控作用，包括細(xì)胞黏附、信號(hào)轉(zhuǎn)導(dǎo)及免疫調(diào)節(jié)等。本產(chǎn)品為科研人員提供了可靠的研究工具，可廣泛應(yīng)用于等多種實(shí)驗(yàn)場(chǎng)景，助力深入探究SIGLEC6在細(xì)胞生物學(xué)、分子免疫學(xué)及相關(guān)疾病機(jī)制中的功能。 產(chǎn)品采用嚴(yán)格的質(zhì)量控制標(biāo)準(zhǔn)，通過多輪純化工藝確保低內(nèi)毒素水平和高純度，批間一致性良好。其重組表達(dá)體系不僅保證了抗體結(jié)構(gòu)的正確折疊，還可實(shí)現(xiàn)穩(wěn)定的規(guī)?；a(chǎn)，滿足不同實(shí)驗(yàn)需求。該抗體適用于人源及部分動(dòng)物源樣本的檢測(cè)分析，為生命科學(xué)領(lǐng)域的基礎(chǔ)研究和藥物研發(fā)提供重要支持。 作為科研級(jí)試劑，本產(chǎn)品僅供實(shí)驗(yàn)室研究使用，不可用于臨床診斷或治療用途。通過特異性識(shí)別SIGLEC6靶點(diǎn)，可幫助研究團(tuán)隊(duì)揭示該分子在疾病發(fā)生發(fā)展中的作用機(jī)制，為開發(fā)新型靶向治療策略提供實(shí)驗(yàn)依據(jù)。
  • Uniprot No.：
  • 基因名：
  • 別名：
    AK006 research-grade biosimilar; AK 006 research-grade biosimilar ;SIGLEC6 antibody; CD33L antibody; CD33L1 antibody; OBBP1 antibody; Sialic acid-binding Ig-like lectin 6 antibody; Siglec-6 antibody; CD33 antigen-like 1 antibody; CDw327 antibody; Obesity-binding protein 1 antibody; OB-BP1 antibody; CD antigen CD327 antibody
  • 反應(yīng)種屬：
    Human
  • 免疫原：
    Recombinant Human SIGLEC6 protein
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標(biāo)記方式：
    Non-conjugated
  • 克隆類型：
    Monoclonal
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    0.01M PBS，pH7.4
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用說明：
    Validation Status Application-specific performance (e.g., in flow cytometry, ELISA, IHC or other assay formats) has not yet been experimentally verified by CUSABIO. Users are advised to determine the optimal working conditions empirically in their own assay systems. Guaranteed Quality ① Antibody purity?> 95% tested by SDS-PAGE. ② Endotoxin level < 0.1EU/ug tested by LAL method.
  • 儲(chǔ)存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    3-4 weeks
  • 用途：
    It is a non-therapeutic biosimilar antibody, owning the same variable region from the corresponding approved therapeutic antibody. In conclusion, it is a research-grade biosimilar antibody and expressed in mammalian cell, which can be directly used as positive controls in drug discovery or used for rapid verification of the biological functions of target protein.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能：
    Putative adhesion molecule that mediates sialic-acid dependent binding to cells. Binds to alpha-2,6-linked sialic acid. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface.
  • 基因功能參考文獻(xiàn)：
    1. Siglec6 and leptin play a role in the aberrant properties characteristic of gestational trophoblastic disease, namely excess proliferation and invasion. PMID: 23089140
    2. Siglec-6 expression is increased in preterm preeclampsia placentas. PMID: 23171684
    3. GdA interacts with Siglec-6 to suppress trophoblast invasiveness by down-regulating the ERK/c-Jun signaling pathway. PMID: 21880722
    4. the negative signaling potential of Siglec-6 may have a role in human-specific placental expression, to slow the tempo of the human birth process PMID: 17580316
    5. Preeclampsia involves changes in the gene expression of SIGLEC6 in placental cytotrophoblasts. PMID: 18818296

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  • 亞細(xì)胞定位：
    [Isoform 1]: Cell membrane; Single-pass type I membrane protein.; [Isoform 2]: Secreted.
  • 蛋白家族：
    Immunoglobulin superfamily, SIGLEC (sialic acid binding Ig-like lectin) family
  • 組織特異性：
    Expressed at high levels in placenta (cyto- and syncytiotrophoblastic cells) and at lower levels in spleen, peripheral blood leukocytes (predominantly B-cells) and small intestine.
  • 數(shù)據(jù)庫(kù)鏈接：

    HGNC: 10875

    OMIM: 604405

    KEGG: hsa:946

    STRING: 9606.ENSP00000401502

    UniGene: Hs.720304



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