SIGLEC15 (PYX-106 Biosimilar) Recombinant Monoclonal Antibody
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貨號:CSB-RA761623MB2HU
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規(guī)格:¥83486
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其他:
產(chǎn)品詳情
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產(chǎn)品描述:SIGLEC15 (PYX-106 Biosimilar Antibody)重組單克隆抗體是一種專為科研用途開發(fā)的生物試劑,旨在為生命科學(xué)研究提供高特異性的分子工具。該抗體針對SIGLEC15(唾液酸結(jié)合免疫球蛋白樣凝集素15)設(shè)計,通過重組DNA技術(shù)在哺乳動物細(xì)胞表達(dá)系統(tǒng)中制備,確保了產(chǎn)品的高純度和批次間穩(wěn)定性。 SIGLEC15作為一種跨膜蛋白,在免疫調(diào)節(jié)、腫瘤微環(huán)境及炎癥反應(yīng)中發(fā)揮重要作用。研究表明,其在多種腫瘤組織中異常表達(dá),可能參與免疫抑制性微環(huán)境的形成,因此成為腫瘤免疫治療機制研究的潛在靶點。本產(chǎn)品可用于等多種實驗方法,助力科研人員深入探究SIGLEC15的生物學(xué)功能及其在疾病發(fā)生發(fā)展中的作用機制。 該重組單克隆抗體經(jīng)過嚴(yán)格的質(zhì)量控制,包括抗體純度檢測(SDS-PAGE和HPLC分析)、特異性驗證(ELISA和實驗)以及活性評估,確保在科研應(yīng)用中具有高靈敏度和低背景干擾。產(chǎn)品提供液體形式,可直接用于實驗或根據(jù)需要進(jìn)行稀釋,使用方便且操作靈活。 作為科研用試劑,SIGLEC15 (PYX-106 Biosimilar Antibody)重組單克隆抗體為免疫學(xué)、腫瘤生物學(xué)、細(xì)胞生物學(xué)等領(lǐng)域的基礎(chǔ)研究和轉(zhuǎn)化醫(yī)學(xué)研究提供了可靠的實驗材料,有助于推動相關(guān)疾病機制的深入探索及潛在治療靶點的發(fā)現(xiàn)。
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Uniprot No.:
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基因名:
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別名:Anti-Siglec-15 monoclonal antibodies(Biosion, Inc.) research-grade biosimilar; Anti-siglec15 monoclonal antibody (Biosion) research-grade biosimilar; BSI060T research-grade biosimilar; BSI 060T research-grade biosimilar; BSI-060T research-grade biosimilar; BSI- 060T research-grade biosimilar; PYX-106 research-grade biosimilar ;SIGLEC15 antibody; CD33L3 antibody; Sialic acid-binding Ig-like lectin 15 antibody; Siglec-15 antibody; CD33 antigen-like 3 antibody
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反應(yīng)種屬:Human
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免疫原:Recombinant Human SIGLEC15 protein
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免疫原種屬:Homo sapiens (Human)
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標(biāo)記方式:Non-conjugated
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克隆類型:Monoclonal
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濃度:It differs from different batches. Please contact us to confirm it.
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保存緩沖液:0.01M PBS,pH7.4
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產(chǎn)品提供形式:Liquid
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應(yīng)用說明:Validation Status
Application-specific performance (e.g., in flow cytometry, ELISA, IHC or other assay formats) has not yet been experimentally verified by CUSABIO. Users are advised to determine the optimal working conditions empirically in their own assay systems.
Guaranteed Quality
① Antibody purity?> 95% tested by SDS-PAGE.
② Endotoxin level < 0.1EU/ug tested by LAL method. -
儲存條件:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期:3-4 weeks
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用途:It is a non-therapeutic biosimilar antibody, owning the same variable region from the corresponding approved therapeutic antibody. In conclusion, it is a research-grade biosimilar antibody and expressed in mammalian cell, which can be directly used as positive controls in drug discovery or used for rapid verification of the biological functions of target protein.
相關(guān)產(chǎn)品
靶點詳情
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功能:Binds sialylated glycoproteins.
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基因功能參考文獻(xiàn):
- Siglec-15 recognizes the tumoral sTn antigen and transduces a signal for enhanced TGF-beta secretion in TAMs PMID: 23035012
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亞細(xì)胞定位:Membrane; Single-pass type I membrane protein.
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蛋白家族:Immunoglobulin superfamily, SIGLEC (sialic acid binding Ig-like lectin) family
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組織特異性:Expressed in macrophage and/or dendritic cells of spleen and lymph nodes.
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數(shù)據(jù)庫鏈接:
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