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SIGLEC10 (ONC-841 Biosimilar) Recombinant Monoclonal Antibody

  • 貨號:
    CSB-RA842706MB1HU
  • 規(guī)格:
    ¥83486
  • 其他:

產(chǎn)品詳情

  • 產(chǎn)品描述:
    SIGLEC10 (ONC-841 Biosimilar Antibody)重組單克隆抗體是一種針對SIGLEC10靶點的高特異性生物試劑,專為生命科學研究設(shè)計。該抗體通過重組DNA技術(shù)在哺乳動物細胞表達系統(tǒng)中制備,具有高純度、高親和力及批次間一致性等特點,為科研人員提供可靠的實驗工具。 SIGLEC10屬于唾液酸結(jié)合免疫球蛋白樣凝集素家族成員,在免疫調(diào)節(jié)、細胞信號轉(zhuǎn)導及炎癥反應(yīng)中發(fā)揮重要作用。該抗體可特異性識別并結(jié)合SIGLEC10蛋白,適用于多種實驗場景,包括、。通過特異性阻斷或檢測SIGLEC10分子,有助于深入研究其在免疫細胞活化、腫瘤微環(huán)境調(diào)控、自身免疫疾病發(fā)生等生理病理過程中的分子機制。 該重組單克隆抗體制備過程嚴格遵循質(zhì)量控制標準,經(jīng)蛋白A親和層析純化,低內(nèi)毒素水平,可有效減少非特異性結(jié)合。產(chǎn)品提供液體形式,配有優(yōu)化的保存緩沖液,確??贵w活性穩(wěn)定。使用時需根據(jù)具體實驗需求進行稀釋,建議通過預實驗確定最佳工作濃度。 作為科研用試劑,SIGLEC10 (ONC-841 Biosimilar Antibody)重組單克隆抗體為探索SIGLEC10相關(guān)信號通路及疾病機制提供有力支持,助力免疫學、腫瘤學及神經(jīng)科學等領(lǐng)域的基礎(chǔ)研究與轉(zhuǎn)化醫(yī)學應(yīng)用。
  • Uniprot No.:
  • 基因名:
  • 別名:
    ONC841 research-grade biosimilar; ONC 841 research-grade biosimilar; ONC-841 research-grade biosimilar ;SIGLEC10 antibody; SLG2 antibody; UNQ477/PRO940 antibody; Sialic acid-binding Ig-like lectin 10 antibody; Siglec-10 antibody; Siglec-like protein 2 antibody
  • 反應(yīng)種屬:
    Human
  • 免疫原:
    Recombinant Human SIGLEC10 protein
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    Non-conjugated
  • 克隆類型:
    Monoclonal
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    0.01M PBS,pH7.4
  • 產(chǎn)品提供形式:
    Liquid
  • 應(yīng)用說明:
    Validation Status
    Application-specific performance (e.g., in flow cytometry, ELISA, IHC or other assay formats) has not yet been experimentally verified by CUSABIO. Users are advised to determine the optimal working conditions empirically in their own assay systems.
    Guaranteed Quality
    ① Antibody purity?> 95% tested by SDS-PAGE.
    ② Endotoxin level < 0.1EU/ug tested by LAL method.
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    3-4 weeks
  • 用途:
    It is a non-therapeutic biosimilar antibody, owning the same variable region from the corresponding approved therapeutic antibody. In conclusion, it is a research-grade biosimilar antibody and expressed in mammalian cell, which can be directly used as positive controls in drug discovery or used for rapid verification of the biological functions of target protein.

產(chǎn)品評價

靶點詳情

  • 功能:
    Putative adhesion molecule that mediates sialic-acid dependent binding to cells. Preferentially binds to alpha-2,3- or alpha-2,6-linked sialic acid. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface. In the immune response, seems to act as an inhibitory receptor upon ligand induced tyrosine phosphorylation by recruiting cytoplasmic phosphatase(s) via their SH2 domain(s) that block signal transduction through dephosphorylation of signaling molecules. Involved in negative regulation of B-cell antigen receptor signaling. The inhibition of B cell activation is dependent on PTPN6/SHP-1. In association with CD24 may be involved in the selective suppression of the immune response to danger-associated molecular patterns (DAMPs) such as HMGB1, HSP70 and HSP90. In association with CD24 may regulate the immune repsonse of natural killer (NK) cells. Plays a role in the control of autoimmunity. During initiation of adaptive immune responses by CD8-alpha(+) dendritic cells inhibits cross-presentation by impairing the formation of MHC class I-peptide complexes. The function seems to implicate recruitment of PTPN6/SHP-1, which dephosphorylates NCF1 of the NADPH oxidase complex consequently promoting phagosomal acidification.
  • 基因功能參考文獻:
    1. soluble CD52 exerts a concerted immunosuppressive effect by first sequestering HMGB1 to nullify its proinflammatory Box B, followed by binding to the inhibitory Siglec-10 receptor, triggering recruitment of SHP1 to the intracellular immunoreceptor tyrosine-based inhibitory motif of Siglec-10 and its interaction with the TCR. PMID: 29997173
    2. Siglec-10 is associated with decreased survival and impaired NK cell function in human hepatocellular carcinoma (HCC). PMID: 25450598
    3. Siglec-10-VAP-1 interaction seems to mediate lymphocyte adhesion to endothelium PMID: 19861682
  • 亞細胞定位:
    [Isoform 1]: Cell membrane; Single-pass type I membrane protein.; [Isoform 2]: Cell membrane; Single-pass type I membrane protein.; [Isoform 3]: Cell membrane; Single-pass type I membrane protein.; [Isoform 4]: Cell membrane; Single-pass type I membrane protein.; [Isoform 5]: Secreted.
  • 蛋白家族:
    Immunoglobulin superfamily, SIGLEC (sialic acid binding Ig-like lectin) family
  • 組織特異性:
    Expressed by peripheral blood leukocytes (eosinophils, monocytes and a natural killer cell subpopulation). Isoform 5 is found to be the most abundant isoform. Found in lymph node, lung, ovary and appendix. Isoform 1 is found at high levels and isoform 2 a
  • 數(shù)據(jù)庫鏈接:

    HGNC: 15620

    OMIM: 606091

    KEGG: hsa:89790

    STRING: 9606.ENSP00000345243

    UniGene: Hs.284813



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