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  4. SERPINF2 (BAY-3018250 Biosimilar) Recombinant Monoclonal Antibody

SERPINF2 (BAY-3018250 Biosimilar) Recombinant Monoclonal Antibody

  • 貨號(hào)：
    CSB-RA021085MB1HU
  • 規(guī)格：
    ￥83486
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品描述：
    SERPINF2 (BAY-3018250 Biosimilar Antibody)重組單克隆抗體是一種專(zhuān)為科研用途設(shè)計(jì)的生物試劑。該抗體以SERPINF2蛋白為靶點(diǎn)，通過(guò)重組DNA技術(shù)在體外表達(dá)制備，具有高特異性和高親和力的特點(diǎn)，為相關(guān)領(lǐng)域的科學(xué)研究提供了可靠的工具。 SERPINF2基因編碼的蛋白質(zhì)屬于絲氨酸蛋白酶抑制劑超家族，在機(jī)體的凝血、纖溶等生理過(guò)程中發(fā)揮重要調(diào)控作用。本產(chǎn)品作為針對(duì)該靶點(diǎn)的單克隆抗體，可廣泛應(yīng)用于蛋白質(zhì)印跡、酶聯(lián)免疫吸附測(cè)定（ELISA）等多種實(shí)驗(yàn)技術(shù)，助力研究人員深入探索SERPINF2蛋白的分子功能、表達(dá)模式及其在疾病發(fā)生發(fā)展中的作用機(jī)制。 該重組單克隆抗體采用標(biāo)準(zhǔn)化的生產(chǎn)工藝，確保了批次間的穩(wěn)定性和一致性。其高度純化的特性有效降低了非特異性結(jié)合，提升了實(shí)驗(yàn)結(jié)果的準(zhǔn)確性和可重復(fù)性。通過(guò)特異性識(shí)別SERPINF2蛋白，研究人員能夠?qū)崿F(xiàn)對(duì)目標(biāo)蛋白的定性檢測(cè)、定量分析及亞細(xì)胞定位等研究目標(biāo)，為闡明相關(guān)生理病理過(guò)程提供關(guān)鍵實(shí)驗(yàn)數(shù)據(jù)。 作為科研工具，SERPINF2 (BAY-3018250 Biosimilar Antibody)重組單克隆抗體適用于基礎(chǔ)醫(yī)學(xué)、生物化學(xué)、分子生物學(xué)等領(lǐng)域的研究工作，為揭示SERPINF2相關(guān)信號(hào)通路及疾病機(jī)制提供有力支持，推動(dòng)相關(guān)領(lǐng)域的科學(xué)發(fā)現(xiàn)和技術(shù)創(chuàng)新。
  • Uniprot No.：
  • 基因名：
  • 別名：
    BAY3018250 research-grade biosimilar; BAY 3018250 research-grade biosimilar ;SERPINF2 antibody; AAP antibody; PLI antibody; Alpha-2-antiplasmin antibody; Alpha-2-AP antibody; Alpha-2-plasmin inhibitor antibody; Alpha-2-PI antibody; Serpin F2 antibody
  • 反應(yīng)種屬：
    Human
  • 免疫原：
    Recombinant Human SERPINF2 protein
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標(biāo)記方式：
    Non-conjugated
  • 克隆類(lèi)型：
    Monoclonal
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    0.01M PBS，pH7.4
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用說(shuō)明：
    Validation Status
    Application-specific performance (e.g., in flow cytometry, ELISA, IHC or other assay formats) has not yet been experimentally verified by CUSABIO. Users are advised to determine the optimal working conditions empirically in their own assay systems.
    Guaranteed Quality
    ① Antibody purity?> 95% tested by SDS-PAGE.
    ② Endotoxin level < 0.1EU/ug tested by LAL method.
  • 儲(chǔ)存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    3-4 weeks
  • 用途：
    It is a non-therapeutic biosimilar antibody, owning the same variable region from the corresponding approved therapeutic antibody. In conclusion, it is a research-grade biosimilar antibody and expressed in mammalian cell, which can be directly used as positive controls in drug discovery or used for rapid verification of the biological functions of target protein.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能：
    Serine protease inhibitor. The major targets of this inhibitor are plasmin and trypsin, but it also inactivates matriptase-3/TMPRSS7 and chymotrypsin.
  • 基因功能參考文獻(xiàn)：
    1. alpha2AP has a profibrotic effect probably not by the action as a plasmin inhibitor, and the blocking of alpha2AP exerts an antifibrotic effect in humans and mice with systemic sclerosis PMID: 26743600
    2. This review presents recent findings regarding the main aspects of the natural heterogeneity of A2AP with particular focus on the functional and possible clinical implications. [review] PMID: 26626994
    3. Possession of the alpha2AP 407Lys allele was negatively associated with AAA, and thus changes in alpha2AP may affect aneurysm growth and development. PMID: 25065555
    4. Changes in plasma A2AP are associated with cardiovascular disease event presentation. PMID: 26088309
    5. A significant correlation was found between soluble fibroblast activation protein levels and alpha2-antiplasmin cleavage in coronary thrombosis. PMID: 25464232
    6. increased N-terminal cleavage of alpha2AP may have a role in liver cirrhosis PMID: 24034420
    7. FXIII-A has a functional role through exposure on the activated platelet membrane where it exerts antifibrinolytic function by cross-linking alpha2AP to fibrin PMID: 25331118
    8. Data suggest serum A2AP (SERPINF2) level can serve as biomarker for diabetic retinopathy; levels of A2AP (but not fibrinogen, plasminogen, or plasminogen activator inhibitor 1) are up-regulated in hyperglycemic type 1 diabetes with retinopathy. PMID: 24818165
    9. protective mediator during gram-negative (pneumo)sepsis, limiting bacterial growth, inflammation, tissue injury, and coagulation PMID: 23992406
    10. Study revealed that plasmin was present in tumor tissue, and that it was responsible for processing progalanin to galanin(1-20) in the extracellular environment. PMID: 21707521
    11. Data suggest that decreased amounts of alpha2-plasmin inhibitor in plasma vs serum ex vivo may reflect reduced factor XIII (FXIII) in vivo; thus, plasma vs serum alpha2-plasmin inhibitor may be useful diagnostic marker for severe FXIII deficiency. PMID: 22205503
    12. fibrinolysis is enhanced by inhibiting enzymatic cleavage of precursor alpha2-antiplasmin PMID: 21251197
    13. Truncation of monocyte chemoattractant protein 1 by plasmin promotes blood-brain barrier disruption. PMID: 21486949
    14. Levels of free full-length alpha2AP were decreased in myocardial infarction (MI); the percentage of C-terminally cleaved alpha2AP was unaltered, and Arg407Lys did not influence alpha2AP levels or MI risk. PMID: 21505192
    15. the antifibrinolytic function of FXIII is independent of fibrin-fibrin cross-linking and is expressed exclusively through alphaAP. PMID: 21471521
    16. ADAMTS13 inactivation by plasmin as a potential cause of thrombotic thrombocytopenic purpura PMID: 20553378
    17. deficiency in patients with Philadelphia chromosome-positive haematologic cancer receiving imatinib mesylate PMID: 19492163
    18. OPN is highly susceptible to cleavage near its integrin-binding motifs, and the protein is a novel substrate for plasmin and cathepsin D PMID: 20071328
    19. FXIIIa substrate, A2AP, sequences suggests that the residue located two positions beyond the reactive glutamine is not conserved. this position makes important contributions to effective FXIIIa-A2AP interactions PMID: 19691486
    20. Multiple Lys residues within alpha 2-antiplasmin contribute, perhaps in a zipper-like fashion, to its binding to the in-tandem, multikringle array that configures the plasmin heavy chain. PMID: 12549929
    21. Alpha2-antiplasmin has an important role in acute pulmonary embolism PMID: 12911586
    22. the Arg6Trp polymorphism may play a significant role in governing the long-term deposition/removal of intravascular fibrin PMID: 17317851
    23. Fibrinolysis is amplified by converting alpha-antiplasmin from a plasmin inhibitor to a substrate PMID: 17883703
    24. Hydroxyethyl starch (HES) dilution enhances fibrinolysis by diminishing alpha2-antiplasmin-plasmin interactions. PMID: 17890952
    25. Sequencing analysis revealed the presence of two alpha2-PI gene variations, both in the second half of exon 10: a frameshift mutation and a G to A transition at nucleotide 11337 in codon 407. PMID: 17961166
    26. Thrombin activatable fibrinolysis inhibitor and alpha(2)-antiplasmin are not markers for recanalization in patients with ischemic stroke treated with recombinant tissue-type plasminogen activator. PMID: 18048863
    27. Plasmin in nephrotic urine activates the epithelial sodium channel PMID: 19073825

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  • 相關(guān)疾?。?/div>
    Alpha-2-plasmin inhibitor deficiency (APLID)
  • 亞細(xì)胞定位：
    Secreted.
  • 蛋白家族：
    Serpin family
  • 組織特異性：
    Expressed by the liver and secreted in plasma.
  • 數(shù)據(jù)庫(kù)鏈接：

    HGNC: 9075

    OMIM: 262850

    KEGG: hsa:5345

    STRING: 9606.ENSP00000321853

    UniGene: Hs.159509



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