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  4. RGMA (Unasnemab Biosimilar) Recombinant Monoclonal Antibody

RGMA (Unasnemab Biosimilar) Recombinant Monoclonal Antibody

  • 貨號(hào)：
    CSB-RA836186MB2HU
  • 規(guī)格：
    ￥83486
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品描述：
    RGMA（Unasnemab Biosimilar Antibody)重組單克隆抗體是一種用于科研領(lǐng)域的生物制劑。該抗體通過重組DNA技術(shù)制備，具有高特異性和均一性，為生命科學(xué)研究提供了可靠的工具。 作為一種重組單克隆抗體，RGMA（Unasnemab）在分子結(jié)構(gòu)上具有高度均一性，能夠特異性識(shí)別并結(jié)合靶分子，為研究生物體內(nèi)特定蛋白質(zhì)的功能、信號(hào)通路以及疾病機(jī)制等提供有力支持。其制備過程采用先進(jìn)的生物工程技術(shù)，確保了產(chǎn)品的質(zhì)量和批次間的穩(wěn)定性，有利于獲得可重復(fù)的實(shí)驗(yàn)結(jié)果。 在科研應(yīng)用中，RGMA（Unasnemab）可用于多種實(shí)驗(yàn)場景，如蛋白質(zhì)印跡、，助力研究人員深入探索生物分子的相互作用、表達(dá)調(diào)控及細(xì)胞生理過程。通過特異性結(jié)合靶標(biāo)，該抗體能夠幫助科研人員實(shí)現(xiàn)對(duì)特定生物分子的定性、定量檢測(cè)和定位分析，為疾病相關(guān)機(jī)制研究、藥物靶點(diǎn)發(fā)現(xiàn)等基礎(chǔ)研究和應(yīng)用研究提供重要支持。 RGMA（Unasnemab Biosimilar Antibody)重組單克隆抗體的出現(xiàn)，為生命科學(xué)領(lǐng)域的研究工作提供了高質(zhì)量的實(shí)驗(yàn)材料，有助于推動(dòng)相關(guān)領(lǐng)域的科學(xué)探索和創(chuàng)新發(fā)展?？蒲腥藛T可根據(jù)具體研究需求，合理應(yīng)用該抗體，以獲取準(zhǔn)確、可靠的實(shí)驗(yàn)數(shù)據(jù)，為科學(xué)研究的深入開展奠定堅(jiān)實(shí)基礎(chǔ)。
  • Uniprot No.：
  • 基因名：
  • 別名：
    MT 3921 research-grade biosimilar; MT-3921 research-grade biosimilar ;RGMA antibody; RGM antibody; Repulsive guidance molecule A antibody; RGM domain family member A antibody
  • 反應(yīng)種屬：
    Human
  • 免疫原：
    Recombinant Human RGMA protein
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標(biāo)記方式：
    Non-conjugated
  • 克隆類型：
    Monoclonal
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    0.01M PBS，pH7.4
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用說明：
    Validation Status
    Application-specific performance (e.g., in flow cytometry, ELISA, IHC or other assay formats) has not yet been experimentally verified by CUSABIO. Users are advised to determine the optimal working conditions empirically in their own assay systems.
    Guaranteed Quality
    ① Antibody purity?> 95% tested by SDS-PAGE.
    ② Endotoxin level < 0.1EU/ug tested by LAL method.
  • 儲(chǔ)存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    3-4 weeks
  • 用途：
    It is a non-therapeutic biosimilar antibody, owning the same variable region from the corresponding approved therapeutic antibody. In conclusion, it is a research-grade biosimilar antibody and expressed in mammalian cell, which can be directly used as positive controls in drug discovery or used for rapid verification of the biological functions of target protein.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能：
    Member of the repulsive guidance molecule (RGM) family that performs several functions in the developing and adult nervous system. Regulates cephalic neural tube closure, inhibits neurite outgrowth and cortical neuron branching, and the formation of mature synapses. Binding to its receptor NEO1/neogenin induces activation of RHOA-ROCK1/Rho-kinase signaling pathway through UNC5B-ARHGEF12/LARG-PTK2/FAK1 cascade, leading to collapse of the neuronal growth cone and neurite outgrowth inhibition. Furthermore, RGMA binding to NEO1/neogenin leads to HRAS inactivation by influencing HRAS-PTK2/FAK1-AKT1 pathway. It also functions as a bone morphogenetic protein (BMP) coreceptor that may signal through SMAD1, SMAD5, and SMAD8.
  • 基因功能參考文獻(xiàn)：
    1. Dysregulation of RGMa plays an important role in the pathology of Parkinson's disease. PMID: 28842419
    2. Thus, we conclude that RGMa inhibits angiogenesis in vitro and in vivo suggesting that its manipulation would be an efficient therapeutic strategy for pro-angiogenic conditions. PMID: 26721439
    3. RGMa expression and promoter methylation status are closely related to colorectal cancer genesis and progression. PMID: 22367090
    4. identification of neogenin-binding site on the repulsive guidance molecule A PMID: 22396795
    5. The expression of RGMA, RGMB and RGMC was evident in most examined prostate cancer cell lines, and also in the prostate cancer tissues PMID: 22076499
    6. Reduced expression of RGMA in breast cancer was associated with breast cancer. PMID: 21617229
    7. The full-length signal peptides of RGMa is functional and furthermore that the C-domains are sufficient and essential for ER targeting, whereas the N-domains are dispensable. Thus, the N-domains are available for additional functions. PMID: 21183991
    8. RGM-A is a unique endogenous inhibitor of leukocyte chemotaxis that limits inflammatory leukocyte traffic PMID: 21467223
    9. Following central nervous system injury, RGM, a novel, potent axonal growth inhibitor, is present in axonal growth impediments: the mature myelin, choroid plexus, and components of the developing scar. PMID: 16216939
    10. RGMa facilitates the use of ActRIIA by endogenous BMP2 and BMP4 ligands that otherwise prefer signaling via BMPRII and increased utilization of ActRIIA leads to generation of an enhanced BMP signal PMID: 17472960
    11. detected a homozygous deletion of chromosomal region 15q26.2 in the cell line HDLM2 encompasing RGMA and CHD2 PMID: 17606441
    12. this study, we show that Unc5B, a member of the netrin receptor family, interacts with neogenin as a coreceptor for RGMa. PMID: 19273616
    13. Frequent inactivation of axon guidance molecule RGMA in human colon cancer through genetic and epigenetic mechanisms. PMID: 19303019

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  • 亞細(xì)胞定位：
    Cell membrane; Lipid-anchor, GPI-anchor.
  • 蛋白家族：
    Repulsive guidance molecule (RGM) family
  • 數(shù)據(jù)庫鏈接：

    HGNC: 30308

    OMIM: 607362

    KEGG: hsa:56963

    STRING: 9606.ENSP00000452126

    UniGene: Hs.271277



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