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  4. RGMA (Elezanumab Biosimilar) Recombinant Monoclonal Antibody

RGMA (Elezanumab Biosimilar) Recombinant Monoclonal Antibody

  • 貨號(hào)：
    CSB-RA836186MB1HU
  • 規(guī)格：
    ￥83486
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品描述：
    RGMA(Elezanumab Biosimilar Antibody)重組單克隆抗體是一種用于科研領(lǐng)域的生物制劑，其核心成分為重組單克隆抗體。該產(chǎn)品基于特定的抗原結(jié)合位點(diǎn)設(shè)計(jì)，能夠特異性識(shí)別并結(jié)合靶標(biāo)分子，在生命科學(xué)研究中具有重要的應(yīng)用價(jià)值。 在科研場(chǎng)景中，RGMA重組單克隆抗體可廣泛用于蛋白質(zhì)檢測(cè)、細(xì)胞分選、信號(hào)通路研究某些實(shí)驗(yàn)。通過(guò)其高度特異性的結(jié)合能力，有助于研究者準(zhǔn)確識(shí)別目標(biāo)蛋白的表達(dá)水平和亞細(xì)胞定位，為疾病機(jī)制研究、藥物靶點(diǎn)驗(yàn)證等提供關(guān)鍵實(shí)驗(yàn)工具。 該抗體采用重組DNA技術(shù)制備，通過(guò)哺乳動(dòng)物細(xì)胞表達(dá)系統(tǒng)進(jìn)行生產(chǎn)，確保了產(chǎn)品的高純度和批次間的穩(wěn)定性。其理化性質(zhì)經(jīng)過(guò)嚴(yán)格驗(yàn)證，包括親和力、特異性、交叉反應(yīng)性等指標(biāo)，可滿足不同實(shí)驗(yàn)體系的需求。 RGMA重組單克隆抗體的應(yīng)用為生命科學(xué)領(lǐng)域的基礎(chǔ)研究和應(yīng)用研究提供了有力支持，有助于推動(dòng)對(duì)生物分子相互作用、細(xì)胞功能調(diào)控等方面的深入探索，為相關(guān)疾病的研究和治療策略開發(fā)奠定實(shí)驗(yàn)基礎(chǔ)?？蒲腥藛T可根據(jù)具體研究目標(biāo)，將其應(yīng)用于等多種實(shí)驗(yàn)方法中，拓展研究的深度和廣度。
  • Uniprot No.：
  • 基因名：
  • 別名：
    ABT-555 research-grade biosimilar; AE12-1Y-QL research-grade biosimilar; Elezanumab research-grade biosimilar; Elezanumab (USAN/INN) research-grade biosimilar; PR-1432051 research-grade biosimilar ;RGMA antibody; RGM antibody; Repulsive guidance molecule A antibody; RGM domain family member A antibody
  • 反應(yīng)種屬：
    Human
  • 免疫原：
    Recombinant Human RGMA protein
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標(biāo)記方式：
    Non-conjugated
  • 克隆類型：
    Monoclonal
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    0.01M PBS，pH7.4
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用說(shuō)明：
    Validation Status
    Application-specific performance (e.g., in flow cytometry, ELISA, IHC or other assay formats) has not yet been experimentally verified by CUSABIO. Users are advised to determine the optimal working conditions empirically in their own assay systems.
    Guaranteed Quality
    ① Antibody purity?> 95% tested by SDS-PAGE.
    ② Endotoxin level < 0.1EU/ug tested by LAL method.
  • 儲(chǔ)存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    3-4 weeks
  • 用途：
    It is a non-therapeutic biosimilar antibody, owning the same variable region from the corresponding approved therapeutic antibody. In conclusion, it is a research-grade biosimilar antibody and expressed in mammalian cell, which can be directly used as positive controls in drug discovery or used for rapid verification of the biological functions of target protein.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能：
    Member of the repulsive guidance molecule (RGM) family that performs several functions in the developing and adult nervous system. Regulates cephalic neural tube closure, inhibits neurite outgrowth and cortical neuron branching, and the formation of mature synapses. Binding to its receptor NEO1/neogenin induces activation of RHOA-ROCK1/Rho-kinase signaling pathway through UNC5B-ARHGEF12/LARG-PTK2/FAK1 cascade, leading to collapse of the neuronal growth cone and neurite outgrowth inhibition. Furthermore, RGMA binding to NEO1/neogenin leads to HRAS inactivation by influencing HRAS-PTK2/FAK1-AKT1 pathway. It also functions as a bone morphogenetic protein (BMP) coreceptor that may signal through SMAD1, SMAD5, and SMAD8.
  • 基因功能參考文獻(xiàn)：
    1. Dysregulation of RGMa plays an important role in the pathology of Parkinson's disease. PMID: 28842419
    2. Thus, we conclude that RGMa inhibits angiogenesis in vitro and in vivo suggesting that its manipulation would be an efficient therapeutic strategy for pro-angiogenic conditions. PMID: 26721439
    3. RGMa expression and promoter methylation status are closely related to colorectal cancer genesis and progression. PMID: 22367090
    4. identification of neogenin-binding site on the repulsive guidance molecule A PMID: 22396795
    5. The expression of RGMA, RGMB and RGMC was evident in most examined prostate cancer cell lines, and also in the prostate cancer tissues PMID: 22076499
    6. Reduced expression of RGMA in breast cancer was associated with breast cancer. PMID: 21617229
    7. The full-length signal peptides of RGMa is functional and furthermore that the C-domains are sufficient and essential for ER targeting, whereas the N-domains are dispensable. Thus, the N-domains are available for additional functions. PMID: 21183991
    8. RGM-A is a unique endogenous inhibitor of leukocyte chemotaxis that limits inflammatory leukocyte traffic PMID: 21467223
    9. Following central nervous system injury, RGM, a novel, potent axonal growth inhibitor, is present in axonal growth impediments: the mature myelin, choroid plexus, and components of the developing scar. PMID: 16216939
    10. RGMa facilitates the use of ActRIIA by endogenous BMP2 and BMP4 ligands that otherwise prefer signaling via BMPRII and increased utilization of ActRIIA leads to generation of an enhanced BMP signal PMID: 17472960
    11. detected a homozygous deletion of chromosomal region 15q26.2 in the cell line HDLM2 encompasing RGMA and CHD2 PMID: 17606441
    12. this study, we show that Unc5B, a member of the netrin receptor family, interacts with neogenin as a coreceptor for RGMa. PMID: 19273616
    13. Frequent inactivation of axon guidance molecule RGMA in human colon cancer through genetic and epigenetic mechanisms. PMID: 19303019

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  • 亞細(xì)胞定位：
    Cell membrane; Lipid-anchor, GPI-anchor.
  • 蛋白家族：
    Repulsive guidance molecule (RGM) family
  • 數(shù)據(jù)庫(kù)鏈接：

    HGNC: 30308

    OMIM: 607362

    KEGG: hsa:56963

    STRING: 9606.ENSP00000452126

    UniGene: Hs.271277



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